Lütjohann, Dieter

Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Lütjohann, D., Breuer, O., Ahlborg, G., Nennesmo, I., Sidén, A., Diczfalusy, U., & Björkhem, I. (1996) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismSteroid Chemistry and Biochemistry

Cited by 682

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 586

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Björkhem, I., Lütjohann, D., Diczfalusy, U., Ståhle, L., Ahlborg, G., & Wahren, J. (1998) · Journal of Lipid Research

Cholesterol and Lipid MetabolismSteroid Chemistry and Biochemistry

Cited by 538

Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease

Gylling, H., Plat, J., Turley, S., Ginsberg, H. N., Ellegård, L., Jessup, W., Jones, P. J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014) · Atherosclerosis

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 529

24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial

Soininen, H., Solomon, A., Visser, P. J., Hendrix, S. B., Blennow, K., Kivipelto, M., Hartmann, T., Hallikainen, I., Hallikainen, M., Helisalmi, S., et al. (2017) · The Lancet Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 241

Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement

Hegele, R. A., Borén, J., Ginsberg, H. N., Arca, M., Averna, M., Binder, C. J., Calabresi, L., Chapman, M. J., Cuchel, M., von Eckardstein, A., et al. (2020) · The Lancet Diabetes & Endocrinology

Lipoproteins and Cardiovascular HealthLipid metabolism and disorders

Cited by 204

ATP‐binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

Wang, N., Yvan‐Charvet, L., Lütjohann, D., Mulder, M., Vanmierlo, T., Kim, T., & Tall, A. R. (2008) · The FASEB Journal

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 184

Mutations in the ANGPTL3 Gene and Familial Combined Hypolipidemia: A Clinical and Biochemical Characterization

Minicocci, I., Montali, A., Robciuc, M. R., Quagliarini, F., Censi, V., Labbadia, G., Gabiati, C., Pigna, G., Sepe, M. L., Pannozzo, F., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 168

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

Lütjohann, D., Brzezinka, A., Barth, E., Abramowski, D., Staufenbiel, M., von Bergmann, K., Beyreuther, K., Multhaup, G., & Bayer, T. A. (2002) · Journal of Lipid Research

Cholesterol and Lipid MetabolismAlzheimer's disease research and treatments

Cited by 158

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V. W., van Vark-van der Zee, L. C., Kuipers, F., Kiliaan, A., Blokland, A., Sijbrands, E. J. G., Steinbusch, H., et al. (2011) · Neurobiology of Aging

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 154

ATF3 Is a Key Regulator of Macrophage IFN Responses

Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., et al. (2015) · The Journal of Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 124

Three-Dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression

Segovia-Miranda, F., Morales-Navarrete, H., Kücken, M., Moser, V., Seifert, S., Repnik, U., Rost, F., Brosch, M., Hendricks, A., Hinz, S., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 109

Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice

Wouters, K., van Bilsen, M., van Gorp, P. J., Bieghs, V., Lütjohann, D., Kerksiek, A., Staels, B., Hofker, M. H., & Shiri-Sverdlov, R. (2010) · FEBS Letters

Liver Disease Diagnosis and TreatmentCholesterol and Lipid Metabolism

Cited by 109

Cholesterol synthesis rate in human hippocampus declines with aging

Thelen, K. M., Falkai, P., Bayer, T. A., & Lütjohann, D. (2006) · Neuroscience Letters

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 107

ABCA1 influences neuroinflammation and neuronal death

Karasinska, J. M., de Haan, W., Franciosi, S., Ruddle, P., Fan, J., Kruit, J. K., Stukas, S., Lütjohann, D., Gutmann, D. H., Wellington, C. L., et al. (2013) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsCholesterol and Lipid Metabolism

Cited by 104

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Bosch-Queralt, M., Cantuti-Castelvetri, L., Damkou, A., Schifferer, M., Schlepckow, K., Alexopoulos, I., Lütjohann, D., Klose, C., Vaculčiaková, L., Masuda, T., et al. (2021) · Nature Metabolism

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 88

Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke

Abboud, S., Karhunen, P. J., Lütjohann, D., Goebeler, S., Luoto, T., Friedrichs, S., Lehtimaki, T., Pandolfo, M., & Laaksonen, R. (2007) · PLoS ONE

Lipoproteins and Cardiovascular HealthCerebrovascular and Carotid Artery Diseases

Cited by 77

Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

Tamboli, I. Y., Prager, K., Thal, D. R., Thelen, K. M., Dewachter, I., Pietrzik, C. U., St. George-Hyslop, P., Sisodia, S. S., De Strooper, B., Heneka, M. T., et al. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 68

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

Wiesmann, M., Zerbi, V., Jansen, D., Haast, R., Lütjohann, D., Broersen, L. M., Heerschap, A., & Kiliaan, A. J. (2016) · Neural Plasticity

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 60

The ABCG8 G574R Variant, Serum Plant Sterol Levels, and Cardiovascular Disease Risk in the Old Order Amish

Horenstein, R. B., Mitchell, B. D., Post, W. S., Lütjohann, D., von Bergmann, K., Ryan, K. A., Terrin, M., Shuldiner, A. R., & Steinle, N. I. (2013) · Arteriosclerosis Thrombosis and Vascular Biology

Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Cited by 36

Dietary Cholesterol and Its Effect on Tau Protein: A Study in Apolipoprotein E-Deficient and P301L Human Tau Mice

Glöckner, F., Meske, V., Lütjohann, D., & Ohm, T. G. (2011) · Journal of Neuropathology & Experimental Neurology

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 35

Apolipoprotein CI Knock-Out Mice Display Impaired Memory Functions

Berbée, J. F. P., Vanmierlo, T., Abildayeva, K., Blokland, A., Jansen, P. J., Lütjohann, D., Gautier, T., Sijbrands, E., Prickaerts, J., Hadfoune, M., et al. (2011) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 25

Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2tm1.1Bird Mouse, a Model for Rett Syndrome

Lütjohann, D., Lopez, A. M., Chuang, J., Kerksiek, A., & Turley, S. D. (2018) · Lipids

Genetics and Neurodevelopmental DisordersCholesterol and Lipid Metabolism

Cited by 11

Anti-PCSK 9 antibodies increase the ratios of the brain-specific oxysterol 24S-hydroxycholesterol to cholesterol and to 27-hydroxycholesterol in the serum

Lütjohann, D., Stellaard, F., Bölükbasi, B., Kerksiek, A., Parhofer, K. G., & Laufs, U. (2021) · British Journal of Clinical Pharmacology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 8