Lehner, Ben

3D structures of individual mammalian genomes studied by single-cell Hi-C

Stevens, T. J., Lando, D., Basu, S., Atkinson, L. P., Cao, Y., Lee, S. F., Leeb, M., Wohlfahrt, K. J., Boucher, W., O’Shaughnessy-Kirwan, A., et al. (2017) · Nature

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 832

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Schuster-Böckler, B., & Lehner, B. (2012) · Nature

Cancer Genomics and DiagnosticsGenomics and Chromatin Dynamics

Cited by 657

Intergenerational and transgenerational epigenetic inheritance in animals

Perez, M. F., & Lehner, B. (2019) · Nature Cell Biology

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 528

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways

Lehner, B., Crombie, C., Tischler, J., Fortunato, A., & Fraser, A. G. (2006) · Nature Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 502

Transgenerational transmission of environmental information in C. elegans

Klosin, A., Casas, E., Hidalgo-Carcedo, C., Vavouri, T., & Lehner, B. (2017) · Science

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 456

The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy

Lindeboom, R. G. H., Vermeulen, M., Lehner, B., & Supek, F. (2019) · Nature Genetics

RNA Research and SplicingRNA regulation and disease

Cited by 327

A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans

Lee, I., Lehner, B., Crombie, C., Wong, W., Fraser, A. G., & Marcotte, E. M. (2008) · Nature Genetics

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 281

The Causes and Consequences of Genetic Interactions (Epistasis)

Domingo, J., Baeza-Centurion, P., & Lehner, B. (2019) · Annual Review of Genomics and Human Genetics

Evolution and Genetic DynamicsRNA and protein synthesis mechanisms

Cited by 242

Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes

Supek, F., & Lehner, B. (2017) · Cell

Cancer Genomics and DiagnosticsDNA Repair Mechanisms

Cited by 192

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

Casanueva, M. O., Burga, A., & Lehner, B. (2012) · Science

Evolution and Genetic DynamicsGenetics, Aging, and Longevity in Model Organisms

Cited by 146

The genetic landscape of a physical interaction

Diss, G., & Lehner, B. (2018) · eLife

Evolution and Genetic DynamicsProtein Structure and Dynamics

Cited by 140

Site-saturation mutagenesis of 500 human protein domains

Beltran, A., Jiang, X., Shen, Y., & Lehner, B. (2025) · Nature

Genomics and Rare DiseasesProtein Structure and Dynamics

Cited by 126

The genetic architecture of protein interaction affinity and specificity

Bendel, A. M., Faure, A. J., Klein, D., Shimada, K., Lyautey, R., Schiffelholz, N., Kempf, G., Cavadini, S., Lehner, B., & Diss, G. (2024) · Nature Communications

Protein Structure and DynamicsEvolution and Genetic Dynamics

Cited by 22

The genetic architecture of protein interaction affinity and specificity

Bendel, A. M., Faure, A. J., Klein, D., Shimada, K., Kempf, G., Cavadini, S., Lehner, B., & Diss, G. (2023) · Nature Communications

Protein Structure and DynamicsEvolution and Genetic Dynamics

Cited by 22