Cited by 146Evolution and Genetic DynamicsGenetics, Aging, and Longevity in Model OrganismsPhysiological and biochemical adaptations

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

Casanueva, M. Olivia, Burga, Alejandro, Lehner, Ben·2012·Science

Abstract

All Worms Are Not Equal: Why do specific mutations not affect all individuals who inherit them? Casanueva et al. (p. 82 , published online 15 December; see the Perspective by Deplancke and Verstrepen ) found that prior exposure to mild environmental stimuli and the stimulation of a stress response in the nematode Caenorhabditis elegans reduced the detrimental effects of diverse mutations. Moreover, because of interindividual variation in stress signaling, this protective effect was not the same in all individuals. In the absence of mutations, a stronger response increased stress resistance but also delayed reproduction. Such variability among individuals may be beneficial in an unpredictable environment, acting as a “bet-hedging” strategy to diversify risk.

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Crossref · 10.1126/science.1213491

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  • Stimulation of a stress response either by heat shock or increased expression of HSF-1 reduces the phenotypic effects of mutations in C. elegans.

    “Furthermore, the link between Hsp90, Hsf1 and environmental stress has been reinforced by the recent observation that stimulation of a stress response either by heat shock or increased expression of HSF-1 reduces the phenotypic effects of mutations in the nematode Caenorhabditis elegans137.”

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Authors
Casanueva, M. O., Burga, A., & Lehner, B.
Affiliations
  • European Molecular Biology Laboratory–Center for Genomic Regulation (EMBL-CRG) Systems Biology Unit, CRG and Universitat Pompeu Fabra, Barcelona, Spain.
  • Universitat Pompeu Fabra (ES)
  • Institució Catalana de Recerca i Estudis Avançats (ES)
Corresponding author
Lehner, Ben
Venue
Science
Published
2012-01-06
Volume
335
Issue
6064
Pages
82-85
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1988263190
Cited by
146
References
49
Citations by year
2026: 3 · 2025: 1 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 12 · 2014: 8 · 2013: 24 · 2012: 12
FWCI
8.78
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Keywords
mutation penetrance, stress response, stress tolerance, reproductive fitness, fitness trade-offs, bet-hedging, interindividual variability, stress signaling, Caenorhabditis elegans, isogenic lines, environmental variability
MeSH terms
Animals, Cell Nucleus, Environment, Heat-Shock Proteins, Mutation, Phenotype, Recombinant Fusion Proteins, Stress, Physiological, Transcription Factors, Signal Transduction, Caenorhabditis elegans, HSP90 Heat-Shock Proteins, Penetrance, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Forkhead Transcription Factors, Genetic Fitness

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