Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans
Abstract
All Worms Are Not Equal: Why do specific mutations not affect all individuals who inherit them? Casanueva et al. (p. 82 , published online 15 December; see the Perspective by Deplancke and Verstrepen ) found that prior exposure to mild environmental stimuli and the stimulation of a stress response in the nematode Caenorhabditis elegans reduced the detrimental effects of diverse mutations. Moreover, because of interindividual variation in stress signaling, this protective effect was not the same in all individuals. In the absence of mutations, a stronger response increased stress resistance but also delayed reproduction. Such variability among individuals may be beneficial in an unpredictable environment, acting as a “bet-hedging” strategy to diversify risk.
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Stimulation of a stress response either by heat shock or increased expression of HSF-1 reduces the phenotypic effects of mutations in C. elegans.
“Furthermore, the link between Hsp90, Hsf1 and environmental stress has been reinforced by the recent observation that stimulation of a stress response either by heat shock or increased expression of HSF-1 reduces the phenotypic effects of mutations in the nematode Caenorhabditis elegans137.”
From Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) · cites this paper as [137]
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- Authors
- Casanueva, M. O., Burga, A., & Lehner, B.
- Affiliations
- European Molecular Biology Laboratory–Center for Genomic Regulation (EMBL-CRG) Systems Biology Unit, CRG and Universitat Pompeu Fabra, Barcelona, Spain.
- Universitat Pompeu Fabra (ES)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Lehner, Ben
- Venue
- Science
- Published
- 2012-01-06
- Volume
- 335
- Issue
- 6064
- Pages
- 82-85
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988263190
- Cited by
- 146
- References
- 49
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 11 · 2018: 13 · 2017: 7 · 2016: 11 · 2015: 12 · 2014: 8 · 2013: 24 · 2012: 12
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- mutation penetrance, stress response, stress tolerance, reproductive fitness, fitness trade-offs, bet-hedging, interindividual variability, stress signaling, Caenorhabditis elegans, isogenic lines, environmental variability
- MeSH terms
- Animals, Cell Nucleus, Environment, Heat-Shock Proteins, Mutation, Phenotype, Recombinant Fusion Proteins, Stress, Physiological, Transcription Factors, Signal Transduction, Caenorhabditis elegans, HSP90 Heat-Shock Proteins, Penetrance, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Forkhead Transcription Factors, Genetic Fitness
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