Tuveson, David A.

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

Clark, C. E., Hingorani, S. R., Mick, R., Combs, C., Tuveson, D. A., & Vonderheide, R. H. (2007) · Cancer Research

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 990

Cancer modeling meets human organoid technology

Tuveson, D., & Clevers, H. (2019) · Science

Cancer Cells and Metastasis3D Printing in Biomedical Research

Cited by 935

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

Tuveson, D. A., Shaw, A. T., Willis, N. A., Silver, D. P., Jackson, E. L., Chang, S., Mercer, K. L., Grochow, R., Hock, H., Crowley, D., et al. (2004) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 798

Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution

Chan-Seng-Yue, M., Kim, J. C., Wilson, G. W., Ng, K., Figueroa, E. F., O’Kane, G. M., Connor, A. A., Denroche, R. E., Grant, R. C., McLeod, J., et al. (2020) · Nature Genetics

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 669

The Differential Effects of Mutant p53 Alleles on Advanced Murine Lung Cancer

Jackson, E. L., Olive, K. P., Tuveson, D. A., Bronson, R., Crowley, D., Brown, M., & Jacks, T. (2005) · Cancer Research

Cancer-related Molecular PathwaysLung Cancer Research Studies

Cited by 553

ROS in Cancer: The Burning Question

Chio, I. I. C., & Tuveson, D. A. (2017) · Trends in Molecular Medicine

Redox biology and oxidative stressCancer and biochemical research

Cited by 532

The utilization of extracellular proteins as nutrients is suppressed by mTORC1

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., & Thompson, C. B. (2015) · Cell

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 457

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

Nielsen, S. R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y.-S., et al. (2016) · Nature Cell Biology

Immune cells in cancerPancreatic and Hepatic Oncology Research

Cited by 441

Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

Driehuis, E., Kolders, S., Spelier, S., Lõhmussaar, K., Willems, S. M., Devriese, L. A., de Bree, R., de Ruiter, E. J., Korving, J., Begthel, H., et al. (2019) · Cancer Discovery

Cancer Cells and MetastasisHead and Neck Cancer Studies

Cited by 408

KrasG12D and Smad4/Dpc4 Haploinsufficiency Cooperate to Induce Mucinous Cystic Neoplasms and Invasive Adenocarcinoma of the Pancreas

Izeradjene, K., Combs, C., Best, M., Gopinathan, A., Wagner, A., Grady, W. M., Deng, C.-X., Hruban, R. H., Adsay, N. V., Tuveson, D. A., et al. (2007) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 379

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Wilson, J., Sangar, V., Hao, Y., Öhlund, D., et al. (2016) · Cell

Genomics, phytochemicals, and oxidative stressPancreatic and Hepatic Oncology Research

Cited by 378

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine

Aguirre, A. J., Nowak, J. A., Camarda, N. D., Moffitt, R. A., Ghazani, A. A., Hazar-Rethinam, M., Raghavan, S., Kim, J., Brais, L. K., Ragon, D., et al. (2018) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 367

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

Braun, B. S., Tuveson, D. A., Kong, N., Le, D. T., Kogan, S. C., Rozmus, J., Le Beau, M. M., Jacks, T. E., & Shannon, K. M. (2004) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchProtein Tyrosine Phosphatases

Cited by 299

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

Chan, I. T., Kutok, J. L., Williams, I. R., Cohen, S., Kelly, L., Shigematsu, H., Johnson, L., Akashi, K., Tuveson, D. A., Jacks, T., et al. (2004) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchProtein Tyrosine Phosphatases

Cited by 270

TP63-mediated enhancer reprogramming drives the squamous subtype of pancreatic ductal adenocarcinoma

Somerville, T. D. D., Xu, Y., Miyabayashi, K., Tiriac, H., Cleary, C. R., Maia-Silva, D., Milazzo, J. P., Tuveson, D. A., & Vakoc, C. R. (2018) · Cell Reports

Pancreatic and Hepatic Oncology ResearchGenomics and Chromatin Dynamics

Cited by 225

Oncogenic KRAS induces NIX-mediated mitophagy to promote pancreatic cancer

Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., Yao, M. A., Alagesan, P., Zaatari, M. N., Park, Y., et al. (2019) · Cancer Discovery

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 198

Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism

Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y.-P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., et al. (2019) · Cell Reports

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 185

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., et al. (2011) · Journal of Clinical Investigation

Prostate Cancer Treatment and ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 185

Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment

Tiriac, H., Bucobo, J. C., Tzimas, D., Grewel, S., Lacomb, J. F., Rowehl, L. M., Nagula, S., Wu, M., Kim, J., Sasson, A., et al. (2018) · Gastrointestinal Endoscopy

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 164

C-Raf Is Required for the Initiation of Lung Cancer by K-RasG12D

Karreth, F. A., Frese, K. K., DeNicola, G. M., Baccarini, M., & Tuveson, D. A. (2011) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 149

Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

Shaw, A. T., Meissner, A., Dowdle, J. A., Crowley, D., Magendantz, M., Ouyang, C., Parisi, T., Rajagopal, J., Blank, L. J., Bronson, R. T., et al. (2007) · Genes & Development

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 131

Decreased serum thrombospondin-1 levels in pancreatic cancer patients up to 24 months prior to clinical diagnosis: association with diabetes mellitus

Jenkinson, C., Elliott, V. L., Evans, A., Oldfield, L., Jenkins, R. E., O'Brien, D. P., Apostolidou, S., Gentry-Maharaj, A., Fourkala, E.-O., Jacobs, I. J., et al. (2016) · Clinical Cancer Research

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 87

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling

Shaashua, L., Ben-Shmuel, A., Pevsner-Fischer, M., Friedman, G., Levi-Galibov, O., Nandakumar, S., Barki, D., Nevo, R., Brown, L. E., Zhang, W., et al. (2022) · Nature Communications

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 79

Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer

Cheng, D. K., Oni, T. E., Thalappillil, J. S., Park, Y., Ting, H.-C., Alagesan, B., Prasad, N. V., Addison, K., Rivera, K. D., Pappin, D. J., et al. (2021) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 30