Saher, Gesine

High cholesterol level is essential for myelin membrane growth

Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 799

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 493

Absence of integrin α7 causes a novel form of muscular dystrophy

Mayer, U., Saher, G., Fässler, R., Bornemann, A., Echtermeyer, F., Mark, H. V. D., Miosge, N., Pösch, E., & Mark, K. V. D. (1997) · Nature Genetics

Muscle Physiology and DisordersCell Adhesion Molecules Research

Cited by 451

Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood–brain barrier integrity

Hammer, C., Stepniak, B., Schneider, A., Papiol, S., Tantra, M., Begemann, M., Sirén, A.-L., Pardo, L. A., Sperling, S., Mohd Jofrry, S., et al. (2014) · Molecular Psychiatry

Autoimmune Neurological Disorders and TreatmentsSystemic Lupus Erythematosus Research

Cited by 342

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

Chrast, R., Saher, G., Nave, K.-A., & Verheijen, M. H. G. (2011) · Journal of Lipid Research

Lipid metabolism and biosynthesisSphingolipid Metabolism and Signaling

Cited by 314

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Düking, T., Winchenbach, J., Neuber, J., Ewers, D., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

Cholesterol in myelin biogenesis and hypomyelinating disorders

Saher, G., & Stumpf, S. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 192

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

Berghoff, S. A., Gerndt, N., Winchenbach, J., Stumpf, S. K., Hosang, L., Odoardi, F., Ruhwedel, T., Böhler, C., Barrette, B., Stassart, R., et al. (2017) · Nature Communications

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 151

Cholesterol: A Novel Regulatory Role in Myelin Formation

Saher, G., Quintes, S., & Nave, K.-A. (2011) · The Neuroscientist

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 144

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice

Sasmita, A. O., Depp, C., Nazarenko, T., Sun, T., Siems, S. B., Ong, E. C., Nkeh, Y. B., Böhler, C., Yu, X., Bues, B., et al. (2024) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 125

Therapy of Pelizaeus-Merzbacher disease in mice by feeding a cholesterol-enriched diet

Saher, G., Rudolphi, F., Corthals, K., Ruhwedel, T., Schmidt, K.-F., Löwel, S., Dibaj, P., Barrette, B., Möbius, W., & Nave, K.-A. (2012) · Nature Medicine

Multiple Sclerosis Research StudiesLysosomal Storage Disorders Research

Cited by 123

Survival of adult neurons lacking cholesterol synthesis in vivo

Fünfschilling, U., Saher, G., Xiao, L., Möbius, W., & Nave, K.-A. (2007) · BMC Neuroscience

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 120

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2024) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 104

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Schäffner, E., Bosch-Queralt, M., Edgar, J. M., Lehning, M., Strauß, J., Fleischer, N., Kungl, T., Wieghofer, P., Berghoff, S. A., Reinert, T., et al. (2023) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 101

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

Berghoff, S. A., Düking, T., Spieth, L., Winchenbach, J., Stumpf, S. K., Gerndt, N., Kusch, K., Ruhwedel, T., Möbius, W., & Saher, G. (2017) · Acta Neuropathologica Communications

Barrier Structure and Function StudiesMultiple Sclerosis Research Studies

Cited by 100

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis

Saito, K., Dubreuil, V., Arai, Y., Wilsch-Bräuninger, M., Schwudke, D., Saher, G., Miyata, T., Breier, G., Thiele, C., Shevchenko, A., et al. (2009) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsCholesterol and Lipid Metabolism

Cited by 88

Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice

Winchenbach, J., Düking, T., Berghoff, S. A., Stumpf, S. K., Hülsmann, S., Nave, K.-A., & Saher, G. (2016) · F1000Research

Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 74

A role for myelin-associated peroxisomes in maintaining paranodal loops and axonal integrity

Kassmann, C. M., Quintes, S., Rietdorf, J., Möbius, W., Sereda, M. W., Nientiedt, T., Saher, G., Baes, M., & Nave, K.-A. (2011) · FEBS Letters

Hereditary Neurological DisordersMultiple Sclerosis Research Studies

Cited by 52

Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons

Späte, E., Zhou, B., Sun, T., Kusch, K., Asadollahi, E., Siems, S. B., Depp, C., Werner, H. B., Saher, G., Hirrlinger, J., et al. (2024) · Glia

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 40

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2025) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7