Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
Open accessAbstract
The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE) and other genes expressed in microglia related to immune, lipid, and endocytic functions. We generated a transgenic knockin mouse expressing HaloTag-tagged APOE and optimized experimental protocols for the biochemical purification of APOE, which enabled us to identify fibrillary aggregates of APOE in mice with amyloid-β (Aβ) amyloidosis and in human AD brain autopsies. These APOE aggregates that stained positive for β sheet-binding dyes triggered Aβ amyloidosis within the endo-lysosomal system of microglia, in a process influenced by microglial lipid metabolism and the JAK/STAT signaling pathway. Taking these observations together, we propose a model for the onset of Aβ amyloidosis in AD, suggesting that the endocytic uptake and aggregation of APOE by microglia can initiate Aβ plaque formation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aβ can bind to lipoproteins such as clusterin (ApoJ) and ApoE in the brain, which facilitates its clearance by microglia via TREM2.
“However, Aβ can bind to lipoproteins such as clusterin (ApoJ) and ApoE in the brain82–84, which facilitates its clearance by microglia via TREM281.”
From INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia (2025) · cites this paper as [81]
In the lysosomal dysfunction section (p. 10), TREM2-deficient microglia have more APOE/Aβ-associated aggregates, supporting a role for TREM2 in limiting their accumulation. The paper does not establish that binding of Aβ to ApoE or clusterin facilitates its clearance via TREM2; its uptake experiments (pp. 12, 15) concern ApoE and do not test that full mechanism. (LLM, conf=0.82)
Experimental — accuracy not yet measuredTREM2 has been shown to bind to Aβ and facilitate its uptake.
“Although TREM2 has been shown to bind to Aβ and facilitate its uptake80,81, the surface expression changes of other receptors involved in Aβ recognition and uptake might have counteracted the effects of increased TREM2 signaling upon INPP5D haploinsufficiency83,84.”
From INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia (2025) · cites this paper as [81]
The reference list (Article, p. 19) names a study reporting that TREM2 binds apolipoproteins and thereby facilitates microglial uptake of Aβ. It does not say TREM2 binds Aβ directly. The TREM2-knockout experiments (p. 10) examine aggregate formation, not direct binding. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works
Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32205-4 · Cited by 5,465 · see citing works
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
Self-citationOakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works
Self-citationCRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens
Concordet, J., & Haeussler, M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky354 · Cited by 2,354 · see citing works
Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I. K., Hägg, S., Athanasiu, L., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0311-9 · Cited by 2,277 · see citing works
Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works
The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990 · see citing works
Microglia in Alzheimer’s disease
Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935 · see citing works
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736 · see citing works
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
Jucker, M., & Walker, L. C. (2013) · Nature · doi:10.1038/nature12481 · Cited by 1,663 · see citing works
Receptor-Mediated Endocytosis: Concepts Emerging from the LDL Receptor System
Goldstein, J. L., Brown, M. S., Anderson, R. G. W., Russell, D. W., & Schneider, W. J. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.000245 · Cited by 1,600 · see citing works
Microglia Biology: One Century of Evolving Concepts
Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525 · see citing works
Single App knock-in mouse models of Alzheimer’s disease
Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., & Saido, T. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3697 · Cited by 1,447 · see citing works
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425 · see citing works
Namba, Y., Tomonaga, M., Kawasaki, H., Otomo, E., & Ikeda, K. (1991) · Brain Research · doi:10.1016/0006-8993(91)91092-f · Cited by 1,157 · see citing works
iPSC-derived human microglia-like cells to study neurological diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154 · see citing works
APOE and Alzheimer’s disease: Advances in genetics, pathophysiology, and therapeutic approaches
Serrano-Pozo, A., Das, S., & Hyman, B. T. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30412-9 · Cited by 1,037 · see citing works
Wightman, D. P., Jansen, I. E., Savage, J. E., Shadrin, A. A., Bahrami, S., Holland, D., Rongve, A., Børte, S., Winsvold, B. S., Drange, O. K., et al. (2021) · Nature Genetics · doi:10.1038/s41588-021-00921-z · Cited by 1,011 · see citing works
Disease-associated astrocytes in Alzheimer’s disease and aging
Habib, N., McCabe, C., Medina, S., Varshavsky, M., Kitsberg, D., Dvir-Szternfeld, R., Green, G., Dionne, D., Nguyen, L., Marshall, J. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0624-8 · Cited by 1,009 · see citing works
Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host
Meyer-Luehmann, M., Coomaraswamy, J., Bolmont, T., Kaeser, S., Schaefer, C., Kilger, E., Neuenschwander, A., Abramowski, D., Frey, P., Jaton, A. L., et al. (2006) · Science · doi:10.1126/science.1131864 · Cited by 971 · see citing works
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease
Chen, W.-T., Lu, A., Craessaerts, K., Pavie, B., Sala Frigerio, C., Corthout, N., Qian, X., Laláková, J., Kühnemund, M., Voytyuk, I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.038 · Cited by 949 · see citing works
Yeh, F. L., Wang, Y., Tom, I., Gonzalez, L. C., & Sheng, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.015 · Cited by 943 · see citing works
Spangenberg, E., Severson, P. L., Hohsfield, L. A., Crapser, J., Zhang, J., Burton, E. A., Zhang, Y., Spevak, W., Lin, J., Phan, N. Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11674-z · Cited by 939 · see citing works
Sala Frigerio, C., Wolfs, L., Fattorelli, N., Thrupp, N., Voytyuk, I., Schmidt, I., Mancuso, R., Chen, W.-T., Woodbury, M. E., Srivastava, G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.099 · Cited by 926 · see citing works
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Irwin, D. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3549 · Cited by 875 · see citing works
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works
High cholesterol level is essential for myelin membrane growth
Saher, G., Brügger, B., Lappe-Siefke, C., Möbius, W., Tozawa, R.-I., Wehr, M. C., Wieland, F., Ishibashi, S., & Nave, K.-A. (2005) · Nature Neuroscience · doi:10.1038/nn1426 · Cited by 799 · see citing works
Self-citationNeuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760 · see citing works
Protein aggregation diseases: pathogenicity and therapeutic perspectives
Aguzzi, A., & O’Connor, T. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3050 · Cited by 750 · see citing works
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Mathys, H., Adaikkan, C., Gao, F., Young, J. Z., Manet, E., Hemberg, M., De Jager, P. L., Ransohoff, R. M., Regev, A., & Tsai, L.-H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.039 · Cited by 740 · see citing works
Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., West, B. L., & Green, K. N. (2016) · Brain · doi:10.1093/brain/aww016 · Cited by 695 · see citing works
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
Roy, E. R., Wang, B., Wan, Y.-W., Chiu, G., Cole, A., Yin, Z., Propson, N. E., Xu, Y., Jankowsky, J. L., Liu, Z., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci133737 · Cited by 563 · see citing works
Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
Efthymiou, A. G., & Goate, A. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0184-x · Cited by 562 · see citing works
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0296-9 · Cited by 555 · see citing works
Self-citationCryo-EM structures of amyloid-β 42 filaments from human brains
Yang, Y., Arseni, D., Zhang, W., Huang, M., Lövestam, S., Schweighauser, M., Kotecha, A., Murzin, A. G., Peak-Chew, S. Y., Macdonald, J., et al. (2022) · Science · doi:10.1126/science.abm7285 · Cited by 546 · see citing works
Xu, Q., Bernardo, A., Walker, D., Kanegawa, T., Mahley, R. W., & Huang, Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5476-05.2006 · Cited by 524 · see citing works
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Blanchard, J. W., Akay, L. A., Davila-Velderrain, J., von Maydell, D., Mathys, H., Davidson, S. M., Effenberger, A., Chen, C.-Y., Maner-Smith, K., Hajjar, I., et al. (2022) · Nature · doi:10.1038/s41586-022-05439-w · Cited by 493 · see citing works
Microglia use TAM receptors to detect and engulf amyloid β plaques
Huang, Y., Happonen, K. E., Burrola, P. G., O’Connor, C., Hah, N., Huang, L., Nimmerjahn, A., & Lemke, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00913-5 · Cited by 483 · see citing works
ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition
DeMattos, R. B., Cirrito, J. R., Parsadanian, M., May, P. C., O'Dell, M. A., Taylor, J. W., Harmony, J. A. K., Aronow, B. J., Bales, K. R., Paul, S. M., et al. (2004) · Neuron · doi:10.1016/s0896-6273(03)00850-x · Cited by 459 · see citing works
ApoE4 Accelerates Early Seeding of Amyloid Pathology
Liu, C.-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C.-W., & Bu, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.013 · Cited by 451 · see citing works
Sadick, J. S., O’Dea, M. R., Hasel, P., Dykstra, T., Faustin, A., & Liddelow, S. A. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.008 · Cited by 415 · see citing works
Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
Grathwohl, S. A., Kälin, R. E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S. A., Odenthal, J., Radde, R., Eldh, T., Gandy, S., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2432 · Cited by 401 · see citing works
Elucidating the Role of TREM2 in Alzheimer’s Disease
Ulrich, J. D., Ulland, T. K., Colonna, M., & Holtzman, D. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.042 · Cited by 325 · see citing works
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis
Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Düking, T., Winchenbach, J., Neuber, J., Ewers, D., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00757-6 · Cited by 307 · see citing works
Self-citationApolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.008 · Cited by 298 · see citing works
Oligodendroglial myelination requires astrocyte-derived lipids
Camargo, N., Goudriaan, A., van Deijk, A.-L. F., Otte, W. M., Brouwers, J. F., Lodder, H., Gutmann, D. H., Nave, K.-A., Dijkhuizen, R. M., Mansvelder, H. D., et al. (2017) · PLOS Biology · doi:10.1371/journal.pbio.1002605 · Cited by 296 · see citing works
Self-citationApolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid β Peptide
Hashimoto, T., Serrano-Pozo, A., Hori, Y., Adams, K. W., Takeda, S., Banerji, A. O., Mitani, A., Joyner, D., Thyssen, D. H., Bacskai, B. J., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1542-12.2012 · Cited by 294 · see citing works
Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., Nahaboo Solim, M. A., Moens, T. G., Paublete, R. M., Ali, S. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.041 · Cited by 290 · see citing works
Fibrillogenesis in Alzheimer's disease of amyloid <i>β</i> peptides and apolipoprotein E
Castano, E. M., Prelli, F., Wisniewski, T., Golabek, A., Kumar, R. A., Soto, C., & Frangione, B. (1995) · Biochemical Journal · doi:10.1042/bj3060599 · Cited by 267 · see citing works
Deczkowska, A., Matcovitch-Natan, O., Tsitsou-Kampeli, A., Ben-Hamo, S., Dvir-Szternfeld, R., Spinrad, A., Singer, O., David, E., Winter, D. R., Smith, L. K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00769-0 · Cited by 260 · see citing works
Apolipoprotein E and Alzheimer’s disease: Findings, hypotheses, and potential mechanisms
Koutsodendris, N., Nelson, M. R., Rao, A., & Huang, Y. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-030421-112756 · Cited by 231 · see citing works
Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease
Lewcock, J. W., Schlepckow, K., Di Paolo, G., Tahirovic, S., Monroe, K. M., & Haass, C. (2020) · Neuron · doi:10.1016/j.neuron.2020.09.029 · Cited by 221 · see citing works
Self-citationMicroglia contribute to the propagation of Aβ into unaffected brain tissue
d’Errico, P., Ziegler-Waldkirch, S., Aires, V., Hoffmann, P., Mezö, C., Erny, D., Monasor, L. S., Liebscher, S., Ravi, V. M., Joseph, K., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-021-00951-0 · Cited by 214 · see citing works
Lipoproteins in the Central Nervous System
LaDu, M. J., Reardon, C. A., Eldik, L. J. V., Fagan, A. M., Bu, G., HOLTZMAN, D., & Getz, G. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06365.x · Cited by 206 · see citing works
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
Kiani Shabestari, S., Morabito, S., Danhash, E. P., McQuade, A., Sanchez, J. R., Miyoshi, E., Chadarevian, J. P., Claes, C., Coburn, M. A., Hasselmann, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110961 · Cited by 167 · see citing works
The role of APOE on lipid homeostasis and inflammation in normal brains
Rebeck, G. W. (2017) · Journal of Lipid Research · doi:10.1194/jlr.r075408 · Cited by 160 · see citing works
Su, B., Bettcher, L., Hsieh, W.-Y., Hornburg, D., Pearson, M. J., Blomberg, N., Giera, M. A., Snyder, M. P., Raftery, D., Bensinger, S. J., et al. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.1c00203 · Cited by 144 · see citing works
Self-citationAn exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains
Millet, A., Ledo, J. H., & Tavazoie, S. F. (2024) · Immunity · doi:10.1016/j.immuni.2023.12.001 · Cited by 132 · see citing works
Ziegler‐Waldkirch, S., d’Errico, P., Sauer, J., Erny, D., Savanthrapadian, S., Loreth, D., Katzmarski, N., Blank, T., Bartos, M., Prinz, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201797021 · Cited by 121 · see citing works
Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods
Tarutani, A., Arai, T., Murayama, S., Hisanaga, S., & Hasegawa, M. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0532-2 · Cited by 109 · see citing works
Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Wagner, J., Degenhardt, K., Veit, M., Louros, N. N., Konstantoulea, K., Skodras, A., Wild, K., Liu, P., Obermüller, U., Bansal, V., et al. (2022) · Nature · doi:10.1038/s41586-022-05440-3 · Cited by 106 · see citing works
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
Hatters, D. M., Zhong, N., Rutenber, E., & Weisgraber, K. H. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.06.080 · Cited by 105 · see citing works
Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.001 · Cited by 93 · see citing works
Self-citationFilipello, F., You, S.-F., Mirfakhar, F. S., Mahali, S., Bollman, B., Acquarone, M., Korvatska, O., Marsh, J. A., Sivaraman, A., Martinez, R., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02568-y · Cited by 81 · see citing works
Hubin, E., Verghese, P. B., van Nuland, N., & Broersen, K. (2019) · FEBS Letters · doi:10.1002/1873-3468.13428 · Cited by 73 · see citing works
Shirotani, K., Tomioka, M., Kremmer, E., Haass, C., & Steiner, H. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.04.011 · Cited by 68 · see citing works
Self-citationPrion-like propagation of β-amyloid aggregates in the absence of APP overexpression
Ruiz‐Riquelme, A., Lau, H. H. C., Stuart, E., Goczi, A. N., Wang, Z., Schmitt‐Ulms, G., & Watts, J. C. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0529-x · Cited by 65 · see citing works
Native Complex Formation between Apolipoprotein E Isoforms and the Alzheimer's Disease Peptide Aβ
Chan, W., Fornwald, J. A., Brawner, M. E., & Wetzel, R. B. (1996) · Biochemistry · doi:10.1021/bi952852v · Cited by 56 · see citing works
Raulin, A.-C., Kraft, L., Al-Hilaly, Y. K., Xue, W.-F., McGeehan, J. E., Atack, J. R., & Serpell, L. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.019 · Cited by 47 · see citing works
Aβ Seeding as a Tool to Study Cerebral Amyloidosis and Associated Pathology
Friesen, M., & Meyer‐Luehmann, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00233 · Cited by 41 · see citing works
Type I interferon remodels lysosome function and modifies intestinal epithelial defense
Zhang, H., Zoued, A., Liu, X., Sit, B., & Waldor, M. K. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010723117 · Cited by 37 · see citing works
Multiscale ATUM-FIB Microscopy Enables Targeted Ultrastructural Analysis at Isotropic Resolution
Kislinger, G., Gnaegi, H., Kerschensteiner, M., Simons, M., Misgeld, T., & Schifferer, M. (2020) · iScience · doi:10.1016/j.isci.2020.101290 · Cited by 20 · see citing works
Self-citationTakacs, C. N., Andréo, U., Belote, R. L., Pulupa, J., Scull, M. A., Gleason, C. E., Rice, C. M., & Simon, S. M. (2016) · Traffic · doi:10.1111/tra.12467 · Cited by 9 · see citing works
Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.
(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Baligács, N., Albertini, G., Borrie, S. C., Serneels, L., Pridans, C., Balusu, S., & De Strooper, B. (2024) · Nature Communications · doi:10.1038/s41467-024-54779-w · Cited by 123 · see citing works
Oligodendrocytes in Alzheimer’s disease pathophysiology
Kedia, S., & Simons, M. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01873-x · Cited by 86 · see citing works
Self-citationFerroptosis and Iron Homeostasis: Molecular Mechanisms and Neurodegenerative Disease Implications
Abdukarimov, N., Kokabi, K., & Kunz, J. (2025) · Antioxidants · doi:10.3390/antiox14050527 · Cited by 83 · see citing works
Liu, Y., Gu, X., Li, Y., Wang, F., Vyas, C. M., Peng, C., Dong, D., Li, Y., Zhang, Y., Zhang, Y., et al. (2025) · Nature Medicine · doi:10.1038/s41591-025-03891-5 · Cited by 54 · see citing works
Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response
Wang, Z., Zhang, L., & Qin, C. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00857-6 · Cited by 54 · see citing works
Yarbro, J. M., Shrestha, H. K., Wang, Z., Zhang, X., Zaman, M., Chu, M., Wang, X., Yu, G., & Peng, J. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00874-5 · Cited by 41 · see citing works
Microglial phagocytosis in Alzheimer disease
Brown, G. C., St George-Hyslop, P., Paolicelli, R. C., & Lemke, G. (2026) · Nature Reviews Neurology · doi:10.1038/s41582-025-01162-y · Cited by 36 · see citing works
The activation of microglia by the complement system in neurodegenerative diseases
Zhao, H., Lv, Y., Xu, J., Song, X., Wang, Q., Zhai, X., Ma, X., Qiu, J., Cui, L., & Sun, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102636 · Cited by 31 · see citing works
Protein aggregation in neurodegenerative diseases
Wang, J., Dai, L., & Zhang, Z. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003802 · Cited by 29 · see citing works
Lipid metabolism and neuroinflammation: What is the link?
Tiwari, V., & Simons, M. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20241232 · Cited by 34 · see citing works
Self-citationZhang, X., Fu, M., Wang, Y., & Wu, T. S. (2025) · Frontiers in Drug Delivery · doi:10.3389/fddev.2025.1644633 · Cited by 30 · see citing works
Experimental modeling of Alzheimer's disease: Translational lessons from cross‐taxon analyses
Yenkoyan, K. B., Kotova, M. M., Apukhtin, K. V., Galstyan, D. S., Amstislavskaya, T. G., Strekalova, T. V., de Abreu, M. S., Chavushyan, V. A., Lim, L. W., Yang, L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70273 · Cited by 29 · see citing works
Fang, M., Zhou, Y., He, K., Lu, Y., Tao, F., & Huang, H. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04775-y · Cited by 31 · see citing works
Chen, J., Zhao, S., Zhou, Y., Wang, L., Chen, Q., & Zheng, K. (2025) · BioScience Trends · doi:10.5582/bst.2025.01148 · Cited by 27 · see citing works
A manifesto for Alzheimer’s disease drug discovery in the era of disease-modifying therapies
Hering, H., Bussière, T., Liu, C., Glajch, K. E., Weihofen, A., Grogan, J. L., & Walsh, D. M. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00872-7 · Cited by 26 · see citing works
Liu, K., Gao, Y.-Z., Wu, X.-M., Hu, X.-Y., Shi, C., He, Q., Wu, H.-P., Yao, H., Ma, D., Yang, J., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110205 · Cited by 22 · see citing works
Zhang, H., Zhou, L., Yang, S., Dong, M., Chen, L., Lu, Y.-L., Zhang, L., Zhang, L., Chu, Y., Xu, L., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.04.009 · Cited by 21 · see citing works
Takatori, S., Kondo, M., & Tomita, T. (2025) · Inflammation and Regeneration · doi:10.1186/s41232-025-00383-4 · Cited by 23 · see citing works
Liu, A., Wang, T., Yang, L., & Zhou, Y. (2025) · Brain Sciences · doi:10.3390/brainsci15070675 · Cited by 22 · see citing works
Type I interferon signalling and interferon‐responsive microglia in health and disease
López‐Atalaya, J. P., & Bhojwani-Cabrera, A. M. (2025) · FEBS Journal · doi:10.1111/febs.70126 · Cited by 19 · see citing works
Li, Y., Fan, Q., Pang, R., Cai, L., Qi, J., Chen, W., Zhang, Y., Chen, C., Yu, W., & Li, P. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03465-9 · Cited by 19 · see citing works
Kang, J., Liu, M., Yang, Q., Dang, X., Li, Q., Wang, T., Qiu, B., Zhang, Y., Guo, X., Li, X., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1558078 · Cited by 18 · see citing works
Zhu, P., Xiao, L., & Wang, Y. (2025) · Fluids and Barriers of the CNS · doi:10.1186/s12987-025-00721-1 · Cited by 15 · see citing works
Immunity in Alzheimer’s disease: From mechanisms to therapies
Chen, X., Holtzman, D. M., & Colonna, M. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.004 · Cited by 17 · see citing works
Neuroinflammation and Disease: Pathways and Opportunities
Hoffman, O., Varvel, N. H., Roopra, A., & Dingledine, R. J. (2025) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-062124-043519 · Cited by 14 · see citing works
Macrophages and Tissue Homeostasis: From Physiological Functions to Disease Onset
Li, Y., Chen, H., & Zhou, S. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl42706 · Cited by 12 · see citing works
Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Yüceer, H., Lee, A., Ma, Y., Çelikkaya, H., Coşacak, M. İ., Haage, V. C., Wang, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.24.634732 · Cited by 12 · see citing works
Zheng, Y., Huang, R., & Pan, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178155 · Cited by 11 · see citing works
Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease
Smyth, L. C. D., Verhaege, D., Standen-Bloom, E., Wu, Y., Gan, Y., Storck, S. E., Boskovic, P., Plog, B. A., Mamuladze, T., Mazzitelli, J. A., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20251860 · Cited by 11 · see citing works
Tsap, M. I., & Shcherbata, H. R. (2025) · Progress in Lipid Research · doi:10.1016/j.plipres.2025.101341 · Cited by 11 · see citing works
Lipid metabolism and metabolites: emerging roles in systemic physiology and metabolic diseases
Xu, J., Lu, D., & Huang, X. (2026) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2026.01.006 · Cited by 10 · see citing works
Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease
McKinney, J. E., Bennett, M. L., & Bennett, F. C. (2026) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-042624-114332 · Cited by 12 · see citing works
Hypercholesterolemia drives microglial dysfunction and weakens response to amyloid plaques
Kaye, S. D., Gold, A., Lin, D., Chen, M., Zhu, J., & Gao, J. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115272 · Cited by 11 · see citing works
Recent advances in Alzheimer’s disease: From molecular mechanisms to therapeutic strategies
Rudman, M. D., Ulrich, J. D., & Holtzman, D. M. (2026) · Cell · doi:10.1016/j.cell.2026.06.006 · Cited by 10 · see citing works
Gao, H., Tian, X., Wu, B., Geng, X., Chen, Y., Song, Y., Yan, Y., Li, X., Ni, W., Zhao, J., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.138205 · Cited by 7 · see citing works
Ebrahimi, R., Bordbar, S., Azad, G., Davoody, S., Mahmoudi, M., & Esmaeilpour, K. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08403-4 · Cited by 8 · see citing works
Haessler, A., Gier, S., Jung, N., & Windbergs, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1516093 · Cited by 8 · see citing works
Vimentin Fragmentation and Its Role in Amyloid-Beta Plaque Deposition in Alzheimer’s Disease
Zhang, L., Wang, J., Yan, Y., Xiang, L., Zhai, X., Cai, L., Sun, Z., Pi, M., Xiong, Q., Zhou, H., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072857 · Cited by 7 · see citing works
Tortolani, D., Decandia, D., Giacovazzo, G., Scipioni, L., Panuccio, A., Ciaramellano, F., Eugelio, F., Fanti, F., Latagliata, E. C., Barbera, L. L., et al. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1571428 · Cited by 6 · see citing works
Milestone Review: The History of Molecular Genetics Analysis of Alzheimer's Disease
Hardy, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70148 · Cited by 6 · see citing works
The emerging role of disulfidptosis in Alzheimer's disease
Zhou, Q., Zheng, N., Chen, Z., Xie, L., Yang, X., Sun, Q., Lin, J., Li, B., & Li, L. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178085 · Cited by 8 · see citing works
Neuroimmune Dysregulation in Alzheimer's Disease: Mechanisms and Therapeutic Strategies.
He, H.-L., Zhu, S.-J., Zhang, C., Wang, H., Li, Y., & Qian, H.-B. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103055 · Cited by 8 · see citing works
Strickland, M. R., Wang, Z., Golden, L. R., Wang, H., Lu, P., Ren, Y., Tabor, G. T., Zhao, N., Ulrich, J. D., Han, X., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101000 · Cited by 8 · see citing works
Wu, J., Tang, J., Huang, D., Wang, Y., Zhou, E., Ru, Q., Xu, G., Chen, L., & Wu, Y. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1482947 · Cited by 7 · see citing works
Xiong, Y., Yang, Y., Ruan, Y., Ou, W., Hu, Z., Li, W., Xiao, N., Liao, W., Liu, J., Liu, Z., et al. (2025) · Experimental Neurobiology · doi:10.5607/en24030 · Cited by 6 · see citing works
Li, Q., Shang, Y., Huang, H., Dai, X., & Lao, F. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05329-y · Cited by 5 · see citing works
Tong, P., Li, X., Li, S., Li, S., Chen, B., Chen, D., & Xia, C. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157591 · Cited by 6 · see citing works
Akinluyi, E. T., Takahashi, K., Connolly, M. G., Poon, W. W., & Macauley, M. S. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00805 · Cited by 5 · see citing works
Programmable CAR immunotherapies for neurodegenerative proteinopathies
Pesce, G., Estivill-Alonso, M., & Ventura, S. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.02.009 · Cited by 5 · see citing works
Lipid metabolism in Alzheimer’s disease
Zhang, J., & Sima, J. (2024) · Aging Research · doi:10.26599/agr.2025.9340037 · Cited by 4 · see citing works
Novel targets for treating neurodegenerative diseases: The PKM2-STAT3-hnRNPA1 feedback loop
Ye, P., Li, Z., & Jiang, H. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107840 · Cited by 4 · see citing works
Singh, K., Foster, M. W., Violette, M. J., Corcoran, A. M., Hotchkiss, K. M., Railton, C. O., Blandford, E. E., Blethen, K. E., Thomas, E. L., McIntosh, W. C., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-21064-9 · Cited by 4 · see citing works
Kim, B.-G., Yuk, M., Park, M., Ryu, H., Park, J., Yu, H., Park, S. S., Hong, J. T., Lim, K., Han, S., et al. (2025) · Brain · doi:10.1093/brain/awaf244 · Cited by 4 · see citing works
INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microglia
Terzioglu, G., Karp, E. S., Heuer, S. E., Chadarevian, J. P., Ahsan, F. M., Haage, V. C., Davtyan, H., Fogo, G. M., Curle, A. J., Ashour, N., et al. (2025) · doi:10.1101/2025.10.27.684632 · Cited by 3 · see citing works
Wei, H., Zhang, G., Xu, Y., Zhao, A., Zheng, Y., Shao, Y. W., Yang, L., Wang, J., & Jiang, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157238 · Cited by 3 · see citing works
Li, Y., Fan, H., Han, X., Ni, M., Hou, X., Xia, H., Shi, Y., Zhang, L., & Sun, J. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05287-5 · Cited by 3 · see citing works
Huang, S., Wu, J., & He, L. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1683204 · Cited by 3 · see citing works
A Question of Origins: Non-neuronal Sources of Amyloid-β
Sasmita, A. O., & Depp, C. (2026) · Neuroscience Bulletin · doi:10.1007/s12264-025-01572-4 · Cited by 3 · see citing works
Self-citationThe metabolic journey of microglia from early development to adulthood
Das, A., Sadeghdoust, M., Templeman, E. C., & Kaushik, D. K. (2024) · Glial health research. · doi:10.1016/j.ghres.2024.100003 · Cited by 3 · see citing works
Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications
Beschörner, N., Xu, Y., Jucker, M., & Ruiz‐Riquelme, A. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70267 · Cited by 2 · see citing works
Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
Zhou, X., Liu, J., Lai, S., Yin, S., Luo, B., Shao, L., & Kang, Y. (2025) · BMEMat · doi:10.1002/bmm2.70050 · Cited by 2 · see citing works
Oleanolic Acid and Alzheimer’s Disease: Mechanistic Hypothesis of Therapeutic Potential
Espinosa-Cabello, J. M., Fernández‐Aparicio, Á., González‐Jiménez, E., Perez-Muñoz, G., Castellano, J. M., & Perona, J. S. (2026) · Applied Sciences · doi:10.3390/app16010494 · Cited by 2 · see citing works
Wang, M., Niu, D.-C., Zhang, Q., Tang, Y.-Q., Zhao, Y., & Chen, F. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.151352 · Cited by 1 · see citing works
Xing, L., Liu, A., Gao, W., Li, J., Yao, M., Song, J., Duan, P., & Li, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103145 · Cited by 2 · see citing works
Hu, P., Guo, S., Ren, Y., Zhao, R., Su, L., Cheng, J., & Tian, X. (2026) · ACS Sensors · doi:10.1021/acssensors.6c01055 · Cited by 2 · see citing works
Yuan, N. Y., Richards, W. D., Parham, K. T., Clark, S. G., & Lebakken, C. S. (2026) · Cells · doi:10.3390/cells15141266 · Cited by 2 · see citing works
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis
Hardy, J., & Lewis, P. A. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00847-8 · Cited by 1 · see citing works
Mapping microglial mechanisms in Alzheimer’s disease: a comprehensive analysis
Wang, X., Guo, Y., Zha, Y., Wang, S., Yang, W., & Jia, Q. (2025) · Experimental Biology and Medicine · doi:10.3389/ebm.2025.10808 · Cited by 1 · see citing works
Palma, A., Stefanelli, R., Trenta, F., Projetti, C., Massa, G., Canterini, S., & Fiorenza, M. T. (2026) · Glia · doi:10.1002/glia.70163 · Cited by 4 · see citing works
Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease
Martínez-Tazo, P., Mejias‐Ortega, M., López-López, V., Bhojwani-Cabrera, A. M., Saxton, E., Canals, S., Hardingham, G. E., Gutiérrez, A., López‐Atalaya, J. P., & Santis, S. D. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70536 · Cited by 1 · see citing works
Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease
Chong, A. E. Y., Sasmita, A. O., Koh, R. Y., & Ling, A. P. K. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70039 · Cited by 1 · see citing works
Self-citationLi, Z., Ming, Q., Fu, L., Yang, J., Lv, Y., Chen, B., & Lu, Z. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1886340 · Cited by 1 · see citing works
Is amyloid beta peptide a driver of inflammaging?
Kechko, O. I., Moskalev, A. A., Franceschi, C., Mitkevich, V. A., & Makarov, A. А. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103280 · Cited by 1 · see citing works
Cruz-Sesé, J., Miron-Alcala, M., Alfonso-Triguero, M., Olalde, J., Ruiz, L., Galbis-Gramage, N., Cortés, L., Escobar, L., Preman, P., Snellinx, A., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117803 · Cited by 1 · see citing works
Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease
Bhattarai, P., Yılmaz, E., Cakir, E. Ö., Tayran, H., Haq, I., Murphy, D., Keller, J. N., Grand, Q. L., Eschbach, J., Çelikkaya, H., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01204-0 · Cited by 1 · see citing works
Harada, R., Kudo, K., Soto, G. C., Iwata, R., Yanai, K., Taki, Y., Kudo, Y., Furumoto, S., & Okamura, N. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00882 · Cited by 1 · see citing works
Lao, P. J., Lee, S., Talmasov, D., Dass, D., Chikwem, N., Johnson, A. S., Smith, A. P., Guzman, D., Okafor, A., Houlihan, H. M., et al. (2024) · medRxiv · doi:10.1101/2024.11.01.24316493 · Cited by 1 · see citing works
ApoE lipidation, not isoform, is the key modulator of Aβ interaction, uptake, and cytotoxicityPreprint
Nurmakova, K., Gomes, G.-N. W., & Levine, Z. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.19.685371 · Cited by 1 · see citing works
Revanna, J. S., Wessendorf-Rodriguez, K. A., Xiao, Q., Sabedot, T. S., Cuoco, M. S., Sarkar, S., Zhou-Yang, L., Lim, C. K., Prozapas, V. N., Wooldridge, R., et al. (2026) · SSRN Electronic Journal · doi:10.64898/2026.05.12.724612 · Cited by 2 · see citing works
Apolipoprotein E aggregation in microglia, seeds β-amyloidosis in Alzheimer’s disease
Jiménez-Acosta, M. A., Luckie-Duque, C. A., & Meraz‐Ríos, M. A. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf007
Cruz-Sesé, J., Miron-Alcala, M., Alfonso-Triguero, M., Olalde, J., Ruiz, L., Galbis-Gramage, N., Cortes, L., Escobar, L., Preman, P., Snellinx, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.28.635271
Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes
Meyer‐Luehmann, M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.01.005
Camprubí-Ferrer, L., Soldán-Hidalgo, J., Axell, E., Dell’Eva, M., García-Cruzado, M., García‐Revilla, J., Yang, Y., Fernández‐Calle, R., Larlham, L., Chouhan, B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.17.643790
Huntingtin knockdown dysregulates autophagic degradation of Apolipoprotein E
Fote, G., McClure, N. R., Bragg, R. M., McKnight, J. I., Thompson, L. M., Carroll, J. B., & Steffan, J. S. (2025) · Journal of Huntington s Disease · doi:10.1177/18796397251391110
Wang, H., Chen, K., & Hou, L. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1692712
Mouse models elucidating the role of apolipoprotein E in neurological conditions
Torres, E. R. S., & Raber, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29090-9.00001-5
Is there a link between multiple sclerosis and Alzheimer disease? A critical note
Jellinger, K. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-03073-0
Konstantoulea, K., Ramakers, M., Borrie, S. C., T’Syen, D., Moechars, D., Śliwińska, M. A., Pradhan, B., Albertini, G., Baligács, N., Tsaka, G., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2516774123
Self-citationJung, D. H., Park, E., Ju, H. C., Moon, C., & Jahanshahi, A. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71322
Xi, R., Zheng, X., Zhao, J., & Fu, Y. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03819-x · Cited by 1 · see citing works
Xiao, Y., Huang, W., Chen, L., Huang, R., Guo, Y., Liu, W., Wang, X. J., Wang, J., Bao, J., & Shu, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27093892
Yan, J., Feng, H., Xia, Q., Shen, D., Jin, H. K., Sun, R., Sun, J. F., Tang, W., Yu, X., Guo, F., et al. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c08045
Hu, A., Tang, X., Xu, Q., Yu, J., Zheng, S., Li, H., Zhang, J. X., & Ye, M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106792
Chan, B., Wong, S. T. C., & Qi, S. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1015702
The diagnostic and therapeutic significance of apolipoprotein E in personalized medicine
Kumar, M., Suryavanshi, A., Mahapatra, D. K., Jaiswal, M., Mandal, V., & Bharti, S. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40563-1.00007-7
Zhang, X., Niu, Y., Wang, X., Wang, X., Li, W., Liu, Z., Xu, H., Sun, Z., & Jiang, W. (2026) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2026.3
Zhang, X., Niu, Y., Wang, X., Wang, X., Li, W., Liu, Z., Xu, H., Sun, Z., & Jiang, W. (2026) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2026.03
Du, Y., Li, L., Du, M., Xu, Z., Zhang, X., & Cao, W. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1860821
Brain macrophages in neurodegeneration
Johnston, R. J., Torres, N. A. P., Li, Y., & Han, C. Z. (2026) · Advances in immunology · doi:10.1016/bs.ai.2026.06.005
Neurodegeneration as a dysregulation of neuroimmune crosstalk
Bennett, F. C., Hong, S. Y., Jiang, N. J., & Marazzi, I. (2026) · Cell · doi:10.1016/j.cell.2026.07.015 · Cited by 2 · see citing works
- Authors
- Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., Damkou, A., Hosang, L., Depp, C., Kamp, F., Scholz, P., Ewers, D., Giera, M., Ischebeck, T., Wurst, W., Wefers, B., Schifferer, M., Willem, M., Nave, K.-A., Haass, C., Arzberger, T., Jäkel, S., Wirths, O., Saher, G., & Simons, M.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
- Leiden University Medical Center (NL)
- University of Münster (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
- LMU Klinikum (DE)
- Institut für Schlaganfall- und Demenzforschung (DE)
- Corresponding author
- Berghoff, Stefan A.
- Simons, Mikael
- ORCID
- Kaji, Seiji
- Berghoff, Stefan A.
- Spieth, Lena
- Schlaphoff, Lennart
- Sasmita, Andrew O.
- Büschgens, Luca
- Kedia, Shreeya
- Zirngibl, Martin
- Damkou, Alkmini
- Depp, Constanze
- Kamp, Frits
- Scholz, Patricia
- Ewers, David
- Giera, Martin
- Ischebeck, Till
- Wurst, Wolfgang
- Wefers, Benedikt
- Schifferer, Martina
- Willem, Michael
- Nave, Klaus-Armin
- Haass, Christian
- Jäkel, Sarah
- Wirths, Oliver
- Saher, Gesine
- Simons, Mikael
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2024-11
- Volume
- 57
- Issue
- 11
- Pages
- 2651-2668.e12
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4403455151
- Cited by
- 104
- References
- 81
- Citations by year
- 2026: 38 · 2025: 58 · 2024: 8
- FWCI
- 29.60
- Type
- journal article
- Language
- en
- Update notices
- erratum (2025-01-14)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunity (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion, cc-by)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion, cc-by)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- DZNE Pub (submittedVersion, cc-by)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Funders
- HORIZON EUROPE European Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- apolipoprotein E, protein aggregation, microglia, Alzheimer's disease, amyloid-beta, seeding, endolysosomal system, JAK/STAT signaling, endocytic uptake, amyloid plaques, HaloTag
- MeSH terms
- Alzheimer Disease, Amyloidosis, Animals, Apolipoproteins E, Brain, Disease Models, Animal, Humans, Mice, Transgenic, Signal Transduction, Amyloid beta-Peptides, Microglia, Lipid Metabolism, STAT Transcription Factors, Mice, Janus Kinases, Plaque, Amyloid, Protein Aggregation, Pathological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
