Heijmans, Bastiaan T.

Persistent epigenetic differences associated with prenatal exposure to famine in humans

Heijmans, B. T., Tobi, E. W., Stein, A. D., Putter, H., Blauw, G. J., Susser, E. S., Slagboom, P. E., & Lumey, L. H. (2008) · Proceedings of the National Academy of Sciences

Birth, Development, and HealthEpigenetics and DNA Methylation

Cited by 3,082

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Kasela, S., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,607

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Võsa, U., Claringbould, A., Westra, H.-J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., et al. (2021) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 2,607

DNA methylation aging clocks: challenges and recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., et al. (2019) · Genome Biology

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 1,025

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 945

DNA methylation signatures link prenatal famine exposure to growth and metabolism

Tobi, E. W., Goeman, J. J., Monajemi, R., Gu, H., Putter, H., Zhang, Y., Slieker, R. C., Stok, A. P., Thijssen, P. E., Müller, F., et al. (2014) · Nature Communications

Birth, Development, and HealthEpigenetics and DNA Methylation

Cited by 630

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-Fernandez, J., Luijk, R., Carnero-Montoro, E., Lawson, D. J., Burrows, K., Suderman, M., et al. (2021) · Nature Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 506

Controlling Bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

the BIOS Consortium, van Iterson, M., van Zwet, E. W., & Heijmans, B. T. (2017) · Genome biology

Genetic Associations and EpidemiologyEpigenetics and DNA Methylation

Cited by 421

Identification of context-dependent expression quantitative trait loci in whole blood

Zhernakova, D. V., Deelen, P., Vermaat, M., van Iterson, M., van Galen, M., Arindrarto, W., van 't Hof, P., Mei, H., van Dijk, F., Westra, H.-J., et al. (2017) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 416

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood

Tobi, E. W., Slieker, R. C., Luijk, R., Dekkers, K. F., Stein, A. D., Xu, K. M., Biobank-based Integrative Omics Studies Consortium, Slagboom, P. E., van Zwet, E. W., Lumey, L. H., et al. (2018) · Science Advances

Birth, Development, and HealthEpigenetics and DNA Methylation

Cited by 284

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

Heijmans, B. T., Kremer, D., Tobi, E. W., Boomsma, D. I., & Slagboom, P. E. (2007) · Human Molecular Genetics

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 238

Commentary: The seven plagues of epigenetic epidemiology

Heijmans, B. T., & Mill, J. (2012) · International Journal of Epidemiology

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 208

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception

Slieker, R. C., Relton, C. L., Gaunt, T. R., Slagboom, P. E., & Heijmans, B. T. (2018) · Epigenetics & Chromatin

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 207

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Mulder, R. H., Neumann, A., Cecil, C. A. M., Walton, E., Houtepen, L. C., Simpkin, A. J., Rijlaarsdam, J., Heijmans, B. T., Gaunt, T. R., Felix, J. F., et al. (2021) · Human Molecular Genetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 165

Heritabilities of Apolipoprotein and Lipid Levels in Three Countries

Beekman, M., Heijmans, B. T., Martin, N. G., Pedersen, N. L., Whitfield, J. B., DeFaire, U., van Baal, G. C. M., Snieder, H., Vogler, G. P., Slagboom, P. E., et al. (2002) · Twin Research

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 133

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study

van den Biggelaar, A. H. J., Huizinga, T. W. J., de Craen, A. J. M., Gussekloo, J., Heijmans, B. T., Frölich, M., & Westendorp, R. G. J. (2004) · Experimental Gerontology

Frailty in Older AdultsImmune Response and Inflammation

Cited by 122

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

Roost, M. S., Slieker, R. C., Bialecka, M., van Iperen, L., Gomes Fernandes, M. M., He, N., Suchiman, H. E. D., Szuhai, K., Carlotti, F., de Koning, E. J. P., et al. (2017) · Nature Communications

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 65

Combined association and linkage analysis applied to the APOE locus

Beekman, M., Posthuma, D., Heijmans, B. T., Lakenberg, N., Suchiman, H. E. D., Snieder, H., de Knijff, P., Frants, R. R., van Ommen, G. J. B., Kluft, C., et al. (2004) · Genetic Epidemiology

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 16