Corn, Jacob E.

Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA

Richardson, C. D., Ray, G. J., DeWitt, M. A., Curie, G. L., & Corn, J. E. (2016) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,098

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

Horlbeck, M. A., Gilbert, L. A., Villalta, J. E., Adamson, B., Pak, R. A., Chen, Y., Fields, A. P., Park, C. Y., Corn, J. E., Kampmann, M., et al. (2016) · eLife

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 894

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

Lee, K., Conboy, M., Park, H. M., Jiang, F., Kim, H. J., Dewitt, M. A., Mackley, V. A., Chang, K., Rao, A., Skinner, C., et al. (2017) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 755

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., et al. (2015) · Science

CRISPR and Genetic EngineeringBiomedical Ethics and Regulation

Cited by 733

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

Fleishman, S. J., Whitehead, T. A., Ekiert, D. C., Dreyfus, C., Corn, J. E., Strauch, E.-M., Wilson, I. A., & Baker, D. (2011) · Science

Protein Structure and DynamicsInfluenza Virus Research Studies

Cited by 585

Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

Mumbach, M. R., Satpathy, A. T., Boyle, E. A., Dai, C., Gowen, B. G., Cho, S. W., Nguyen, M. L., Rubin, A. J., Granja, J. M., Kazane, K. R., et al. (2017) · Nature Genetics

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 490

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

DeWitt, M. A., Magis, W., Bray, N. L., Wang, T., Berman, J. R., Urbinati, F., Heo, S.-J., Mitros, T., Muñoz, D. P., Boffelli, D., et al. (2016) · Science Translational Medicine

CRISPR and Genetic EngineeringHemoglobinopathies and Related Disorders

Cited by 477

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq

Wienert, B., Wyman, S. K., Richardson, C. D., Yeh, C. D., Akcakaya, P., Porritt, M. J., Morlock, M., Vu, J. T., Kazane, K. R., Watry, H. L., et al. (2019) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 434

SLC19A1 transports immunoreactive cyclic dinucleotides.

Luteijn, R. D., Zaver, S. A., Gowen, B. G., Wyman, S. K., Garelis, N. E., Onia, L., McWhirter, S. M., Katibah, G. E., Corn, J. E., Woodward, J. J., et al. (2019) · Nature

interferon and immune responsesDrug Transport and Resistance Mechanisms

Cited by 379

Discovery of stimulation-responsive immune enhancers with CRISPR activation

Simeonov, D. R., Gowen, B. G., Boontanrart, M., Roth, T. L., Gagnon, J. D., Mumbach, M. R., Satpathy, A. T., Lee, Y., Bray, N. L., Chan, A. Y., et al. (2017) · Nature

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 297

Atlastins remodel the endoplasmic reticulum for selective autophagy

Liang, J. R., Lingeman, E., Ahmed, S., & Corn, J. E. (2018) · Journal of Cell Biology

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 158

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

Dillon, M., Yin, Y., Zhou, J., McCarty, L., Ellerman, D., Slaga, D., Junttila, T. T., Han, G., Sandoval, W., Ovacik, M. A., et al. (2017) · mAbs

Monoclonal and Polyclonal Antibodies ResearchViral Infectious Diseases and Gene Expression in Insects

Cited by 75

C-terminal amides mark proteins for degradation via SCF/FBXO31

Muhar, M., Farnung, J., Hofmann, R., Cernakova, M., Sidiropoulos, N. D., Bode, J. W., & Corn, J. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 5