Ittner, Lars M.

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 1,821

Animal models of Alzheimer's disease and frontotemporal dementia

Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 676

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Rhein, V., Song, X., Wiesner, A., Ittner, L. M., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., et al. (2009) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 655

Tau Aggregation and Its Interplay with Amyloid-β

Nisbet, R. M., Polanco, J.-C., Ittner, L. M., & Götz, J. (2015) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 359

Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer’s disease models

van Eersel, J., Ke, Y. D., Liu, X., Delerue, F., Kril, J. J., Götz, J., & Ittner, L. M. (2010) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 284

Neuroinflammation in frontotemporal dementia

Bright, F., Werry, E. L., Dobson-Stone, C., Piguet, O., Ittner, L. M., Halliday, G. M., Hodges, J. R., Kiernan, M. C., Loy, C. T., Kassiou, M., et al. (2019) · Nature Reviews Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 280

Dendritic Tau in Alzheimer’s Disease

Ittner, A., & Ittner, L. M. (2018) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 278

Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice

Ittner, A., Chua, S. W., Bertz, J., Volkerling, A., van der Hoven, J., Gladbach, A., Przybyla, M., Bi, M., van Hummel, A., Stevens, C. H., et al. (2016) · Science

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 263

Neuronal MicroRNA Deregulation in Response to Alzheimer's Disease Amyloid-β

Schonrock, N., Ke, Y. D., Humphreys, D., Staufenbiel, M., Ittner, L. M., Preiss, T., & Götz, J. (2010) · PLoS ONE

Alzheimer's disease research and treatmentsMicroRNA in disease regulation

Cited by 211

Tau exacerbates excitotoxic brain damage in an animal model of stroke

Bi, M., Gladbach, A., van Eersel, J., Ittner, A., Przybyla, M., van Hummel, A., Chua, S. W., van der Hoven, J., Lee, W. S., Müller, J., et al. (2017) · Nature Communications

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 167

Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

Bi, M., Ittner, A., Ke, Y. D., Götz, J., & Ittner, L. M. (2011) · PLoS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 153

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.

van Eersel, J., Ke, Y. D., Gladbach, A., Bi, M., Götz, J., Kril, J. J., & Ittner, L. M. (2011) · PLoS ONE

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 130

Neuronal network disintegration: common pathways linking neurodegenerative diseases

Ahmed, R. M., Devenney, E. M., Irish, M., Ittner, A., Naismith, S., Ittner, L. M., Rohrer, J. D., Halliday, G. M., Eisen, A., Hodges, J. R., et al. (2016) · Journal of Neurology, Neurosurgery & Psychiatry

Functional Brain Connectivity StudiesAlzheimer's disease research and treatments

Cited by 128

Tau physiology and pathomechanisms in frontotemporal lobar degeneration

Bodea, L., Eckert, A., Ittner, L. M., Piguet, O., & Götz, J. (2016) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 104

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

Martínez-Mármol, R., Giordano-Santini, R., Kaulich, E., Cho, A.-N., Przybyla, M., Riyadh, M. A., Robinson, E., Chew, K. Y., Amor, R., Meunier, F. A., et al. (2023) · Science Advances

SARS-CoV-2 and COVID-19 ResearchLong-Term Effects of COVID-19

Cited by 94

Physiological changes in neurodegeneration—mechanistic insights and clinical utility

Ahmed, R. M., Ke, Y. D., Vucic, S., Ittner, L. M., Seeley, W., Hodges, J. R., Piguet, O., Halliday, G., & Kiernan, M. C. (2018) · Nature Reviews Neurology

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

Cited by 91

TDP-43 and Inflammation: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Bright, F., Chan, G., van Hummel, A., Ittner, L. M., & Ke, Y. D. (2021) · International Journal of Molecular Sciences

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 71

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

Nilsen, L. H., Rae, C., Ittner, L. M., Götz, J., & Sonnewald, U. (2013) · Journal of Cerebral Blood Flow & Metabolism

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 62

Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis

Katzeff, J. S., Bright, F., Phan, K., Kril, J. J., Ittner, L. M., Kassiou, M., Hodges, J. R., Piguet, O., Kiernan, M. C., Halliday, G. M., et al. (2022) · Brain

Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment Research

Cited by 48

Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes

Tan, R. H., Kril, J. J., Yang, Y., Tom, N., Hodges, J. R., Villemagne, V. L., Rowe, C. C., Leyton, C. E., Kwok, J. B. J., Ittner, L. M., et al. (2017) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 48

Substrate-specific reduction of PP2A activity exaggerates tau pathology

Deters, N., Ittner, L. M., & Götz, J. (2009) · Biochemical and Biophysical Research Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 39

Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice

Schild, A., Ittner, L. M., & Götz, J. (2006) · Biochemical and Biophysical Research Communications

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 38

Sphingosine kinase 2 potentiates amyloid deposition but protects against hippocampal volume loss and demyelination in a mouse model of Alzheimer’s disease

Lei, M., Teo, J. D., Song, H., McEwen, H. P., Yup Lee, J., Couttas, T. A., Duncan, T., Chesworth, R., Bertz, J., Przybyla, M., et al. (2019) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsSphingolipid Metabolism and Signaling

Cited by 27

Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice

Schild, A., Isenmann, S., Tanimoto, N., Tonagel, F., Seeliger, M. W., Ittner, L. M., Kretz, A., Ogris, E., & Götz, J. (2006) · Mechanisms of Development

Ocular Disorders and TreatmentsProtein Tyrosine Phosphatases

Cited by 17