DeFronzo, Ralph A.

Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.

Del Prato, S., Bonadonna, R. C., Bonora, E., Gulli, G., Solini, A., Shank, M., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 170

Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.

Bonadonna, R. C., Del Prato, S., Saccomani, M. P., Bonora, E., Gulli, G., Ferrannini, E., Bier, D., Cobelli, C., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 149

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

Abdul-Ghani, M. A., & DeFronzo, R. A. (2008) · Current Diabetes Reports

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 146

Metabolic and molecular basis of insulin resistance

Bajaj, M., & DeFronzo, R. A. (2003) · Journal of Nuclear Cardiology

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 131

Sustained Reduction in Plasma Free Fatty Acid Concentration Improves Insulin Action without Altering Plasma Adipocytokine Levels in Subjects with Strong Family History of Type 2 Diabetes

Bajaj, M., Suraamornkul, S., Kashyap, S., Cusi, K., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 109

Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes

Kashyap, S. R., Belfort, R., Berria, R., Suraamornkul, S., Pratipranawatr, T., Finlayson, J., Barrentine, A., Bajaj, M., Mandarino, L., DeFronzo, R., et al. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 103

Menstrual cyclicity has a profound effect on glucose homeostasis.

Diamond, M. P., Simonson, D. C., & DeFronzo, R. A. (1989) · Fertility and Sterility

Ovarian function and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 98

Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals

Pendergrass, M., Bertoldo, A., Bonadonna, R., Nucci, G., Mandarino, L., Cobelli, C., & DeFronzo, R. A. (2007) · American Journal of Physiology-Endocrinology and Metabolism

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 87

Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats

Koopmans, S. J., Ohman, L., Haywood, J. R., Mandarino, L. J., & DeFronzo, R. A. (1997) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 63

Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes

Clarke, G. D., Solis-Herrera, C., Molina-Wilkins, M., Martinez, S., Merovci, A., Cersosimo, E., Chilton, R. J., Iozzo, P., Gastaldelli, A., Abdul-Ghani, M., et al. (2017) · Diabetes Care

Cardiovascular Function and Risk FactorsDiabetes Treatment and Management

Cited by 63

Normalization of Plasma Glucose Concentration by Insulin Therapy Improves Insulin-Stimulated Glycogen Synthesis in Type 2 Diabetes

Pratipanawatr, T., Cusi, K., Ngo, P., Pratipanawatr, W., Mandarino, L. J., & DeFronzo, R. A. (2002) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 61

Durability of triple combination therapy versus stepwise addition therapy in patients with new-onset T2DM: 3-year follow-up of EDICT

Abdul-Ghani, M., Puckett, C., Adams, J., Khattab, A., Baskoy, G., Cersosimo, E., Triplitt, C., & DeFronzo, R. A. (2021) · Diabetes Care

Diabetes Treatment and ManagementDiabetes Management and Research

Cited by 55

Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis

Ferrannini, E., Gastaldelli, A., Matsuda, M., Miyazaki, Y., Pettiti, M., Glass, L., & DeFronzo, R. A. (2003) · The Journal of Clinical Endocrinology & Metabolism

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 46

Regulation of hexokinase II expression in human skeletal muscle in vivo

Vogt, C., Ardehali, H., Iozzo, P., Yki-Järvinen, H., Koval, J., Maezono, K., Pendergrass, M., Printz, R., Granner, D., DeFronzo, R., et al. (2000) · Metabolism

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 45

Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial

Wexler, D. J., de Boer, I. H., Ghosh, A., Younes, N., Bebu, I., Inzucchi, S. E., McGill, J. B., Mudaliar, S., Schade, D., Steffes, M. W., et al. (2023) · JAMA Internal Medicine

Chronic Kidney Disease and DiabetesDiabetes Treatment and Management

Cited by 39

The Insulin-Sensitizer Pioglitazone Remodels Adipose Tissue Phospholipids in Humans

Palavicini, J. P., Chavez-Velazquez, A., Fourcaudot, M., Tripathy, D., Pan, M., Norton, L., DeFronzo, R. A., & Shannon, C. E. (2021) · Frontiers in Physiology

Lipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic Diseases

Cited by 36

Successful Treatment of Prediabetes in Clinical Practice: Targeting Insulin Resistance and β-Cell Dysfunction

Armato, J., DeFronzo, R. A., Abdul-Ghani, M., & Ruby, R. (2012) · Endocrine Practice

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 35

Exercise in the treatment of type II diabetes

Koivisto, V. A., & DeFronzo, R. A. (1983) · Acta Endocrinologica

Physical Activity and HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 35

Decreased Non–Insulin-Dependent Glucose Clearance Contributes to the Rise in Fasting Plasma Glucose in the Nondiabetic Range

Jani, R., Molina, M., Matsuda, M., Balas, B., Chavez, A., DeFronzo, R. A., & Abdul-Ghani, M. (2008) · Diabetes Care

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 32

Intensive glycemic control improves long-term renal outcomes in type 2 diabetes in the Veterans Affairs Diabetes Trial (VADT)

Agrawal, L., Azad, N., Bahn, G. D., Reaven, P. D., Hayward, R. A., Reda, D. J., Emanuele, N. V., VADT Study Group, Abraira, C., Duckworth, W. C., et al. (2019) · Diabetes Care

Chronic Kidney Disease and DiabetesDiabetes Treatment and Management

Cited by 20