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Cited by 32Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetesDiet, Metabolism, and Disease

Decreased Non–Insulin-Dependent Glucose Clearance Contributes to the Rise in Fasting Plasma Glucose in the Nondiabetic Range

Jani, Rucha, Molina, Marjorie, Matsuda, Masafumi, Balas, Bogdan, Chavez, Alberto, DeFronzo, Ralph A., Abdul-Ghani, Muhammad·2008·Diabetes Care
DOI 10.2337/dc07-1593
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Abstract

OBJECTIVE—To assess the contribution of decreased glucose clearance to the rise in fasting plasma glucose (FPG) in the nondiabetic range. RESEARCH DESIGN AND METHODS—A total of 120 subjects with normal glucose tolerance received an oral glucose tolerance test and euglycemic insulin clamp with 3-[3H]glucose. The basal and insulin-stimulated rates of glucose appearance, glucose disappearance, and glucose clearance and the basal hepatic insulin resistance index were calculated. Simple Pearson's correlation was used to assess the relationship between variables. RESULTS—The increase in FPG (range 75–125 mg/dl) correlated (r = 0.32, P < 0.0001) with the increase in BMI (20–50 kg/m2). The fasting plasma insulin (FPI) concentration also increased progressively with the increase in BMI (r = 0.62, P < 0.0001). However, despite increasing FPI, the basal glucose clearance rate declined and correlated with the increase in BMI (r = −0.56, P < 0.0001). Basal hepatic glucose production (HGP) decreased with increasing BMI (r = −0.51, P < 0.0001) and correlated inversely with the increase in FPI (r = −0.32, P < 0.0001). The hepatic insulin resistance (basal HGP × FPI) increased with rising BMI (r = 0.52, P < 0.0001). During the insulin clamp, glucose disposal declined with increasing BMI (r = −0.64, P < 0.0001) and correlated with the basal glucose clearance (r = 0.39, P < 0.0001). CONCLUSIONS—These results demonstrate that in nondiabetic subjects, rising FPG is associated with a decrease (not an increase) in basal hepatic glucose production and is explained by a reduction in glucose clearance.

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Crossref · 10.2337/dc07-1593

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  • Non-insulin-dependent glucose uptake in skeletal muscle is decreased in insulin-resistant individuals.

    “The noninsulin dependent glucose uptake in skeletal muscle also is decreased in insulin resistant individuals [47].”

    From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [47]

  • IFG is characterized primarily by impaired hepatic insulin sensitivity and a decrease in the first-phase insulin response.

    “IFG is characterized primarily by impaired hepatic insulin sensitivity and a decrease in the first-phase insulin response”

    From The Vasculature in Prediabetes (2018) · cites this paper as [11]

  • IGT is characterized by impaired muscle insulin sensitivity as well as early and late phase insulin responses.

    “IGT is characterized by impaired muscle insulin sensitivity as well as early and late phase insulin responses.”

    From The Vasculature in Prediabetes (2018) · cites this paper as [11]

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Authors
Jani, R., Molina, M., Matsuda, M., Balas, B., Chavez, A., DeFronzo, R. A., & Abdul-Ghani, M.
Affiliations
  • The University of Texas at San Antonio Health Science Center (US)
  • From the Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas
ORCID
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2008-02-01
Volume
31
Issue
2
Pages
311-315
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc07-1593
OpenAlex
W2115161226
Cited by
32
References
21
Citations by year
2025: 1 · 2024: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 2
FWCI
2.17
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
fasting blood glucose, glucose clearance, hepatic glucose production, hepatic insulin resistance, insulin resistance, glucose disposal, body mass index, fasting insulin, insulin-stimulated glucose metabolism
MeSH terms
Adult, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Female, Glucose Tolerance Test, Humans, Insulin, Liver, Male, Metabolic Clearance Rate, Reference Values, Glucose Clamp Technique, Body Mass Index

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