Metabolic and molecular basis of insulin resistance

Role of Insulin Resistance in Human Disease

Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

Cohen, P. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.002321 · Cited by 2,547 · see citing works

The Triumvirate: β-Cell, Muscle, Liver: A Collusion Responsible for NIDDM

DeFronzo, R. A. (1988) · Diabetes · doi:10.2337/diab.37.6.667 · Cited by 2,456 · see citing works

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

DeFronzo, R. A., Jacot, E., Jequier, E., Maeder, E., Wahren, J., & Felber, J. P. (1981) · Diabetes · doi:10.2337/diab.30.12.1000 · Cited by 1,770 · see citing works

Banting Lecture 2001

McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435 · see citing works

Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus

Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295 · see citing works

Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by¹³C Nuclear Magnetic Resonance Spectroscopy

Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

DeFronzo, R. A., Gunnarsson, R., Björkman, O., Olsson, M., & Wahren, J. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111938 · Cited by 1,167 · see citing works

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139 · see citing works

Diabetes trends in the U.S.: 1990-1998.

Mokdad, A. H., Ford, E. S., Bowman, B. A., Nelson, D. E., Engelgau, M. M., Vinicor, F., & Marks, J. S. (2000) · Diabetes Care · doi:10.2337/diacare.23.9.1278 · Cited by 1,042 · see citing works

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., & Ui, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41901-6 · Cited by 917 · see citing works

Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

Virkamäki, A., Ueki, K., & Kahn, C. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6609 · Cited by 854 · see citing works

Measurement of Plasma Glucose, Free Fatty Acid, Lactate, and Insulin for 24 h in Patients With NIDDM

Reaven, G. M., Hollenbeck, C., Jeng, C.-Y., Wu, M. S., & Chen, Y.-D. I. (1988) · Diabetes · doi:10.2337/diab.37.8.1020 · Cited by 753 · see citing works

Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 Diabetes

Cline, G. W., Petersen, K. F., Krssak, M., Shen, J., Hundal, R. S., Trajanoski, Z., Inzucchi, S., Dresner, A., Rothman, D. L., & Shulman, G. I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410404 · Cited by 675 · see citing works

Untitled work

(1997) · Diabetes reviews · Cited by 671 · see citing works

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

Kolterman, O., Gray, R. S., Griffin, J., BURSTEIN, P. J., Insel, J. R., Scarlett, J. A., & Olefsky, J. M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110350 · Cited by 629 · see citing works

Renal Gluconeogenesis

Gerich, J. E., Meyer, C., Woerle, H. J., & Stümvoll, M. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.382 · Cited by 602 · see citing works

Non-Insulin-Dependent Diabetes Mellitus — A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance

Polonsky, K. S., Sturis, J., & Bell, G. I. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341207 · Cited by 590 · see citing works

Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.

Dunaif, A., Xia, J., Book, C. B., Schenker, E., & Tang, Z. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118126 · Cited by 561 · see citing works

Quantitation of Hepatic Glycogenolysis And Gluconeogenesis in Fasting Humans With ¹³ C NMR

Rothman, D. L., Magnusson, I., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1991) · Science · doi:10.1126/science.1948033 · Cited by 546 · see citing works

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

Dent, P., Lavoinne, A., Nakielny, S., Caudwell, F. B., Watt, P., & Cohen, P. (1990) · Nature · doi:10.1038/348302a0 · Cited by 519 · see citing works

Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake

DeFronzo, R. A., Ferrannini, E., & Simonson, D. C. (1989) · Metabolism · doi:10.1016/0026-0495(89)90129-7 · Cited by 515 · see citing works

Activation of phosphatidylinositol 3-kinase by insulin.

Ruderman, N. B., Kapeller, R., White, M. F., & Cantley, L. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1411 · Cited by 511 · see citing works

Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man

DeFronzo, R. A., Ferrannini, E., Hendler, R., Felig, P., & Wahren, J. (1983) · Diabetes · doi:10.2337/diab.32.1.35 · Cited by 509 · see citing works

Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo.

Cherrington, A. D. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1198 · Cited by 500 · see citing works

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf

Cross, D. A. E., Alessi, D. R., Vandenheede, J. R., McDowell, H. E., Hundal, H. S., & Cohen, P. (1994) · Biochemical Journal · doi:10.1042/bj3030021 · Cited by 474 · see citing works

Insulin Resistance in Morbid Obesity

Greco, A. V., Mingrone, G., Giancaterini, A., Manco, M., Morroni, M., Cinti, S., Granzotto, M., Vettor, R., Camastra, S., & Ferrannini, E. (2002) · Diabetes · doi:10.2337/diabetes.51.1.144 · Cited by 442 · see citing works

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

Ryysy, L., Häkkinen, A. M., Goto, T., Vehkavaara, S., Westerbacka, J., Halavaara, J., & Yki-Järvinen, H. (2000) · Diabetes · doi:10.2337/diabetes.49.5.749 · Cited by 431 · see citing works

Predominant Role of Gluconeogenesis in Increased Hepatic Glucose Production in NIDDM

Consoli, A., Nurjhan, N., Capani, F., & Gerich, J. E. (1989) · Diabetes · doi:10.2337/diab.38.5.550 · Cited by 406 · see citing works

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM

Zierath, J. R., He, L., Gumà, A., Wahlström, E. O., Klip, A., & Wallberg-Henriksson, H. (1996) · Diabetologia · doi:10.1007/bf02658504 · Cited by 402 · see citing works

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.35.20801 · Cited by 396 · see citing works

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

White, M. F., Livingston, J. N., Backer, J., Lauris, V., Dull, T. J., Ullrich, A., & Kahn, C. R. (1988) · Cell · doi:10.1016/s0092-8674(88)80008-4 · Cited by 369 · see citing works

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

Caro, J. F., Sinha, M. K., Raju, S. M., Ittoop, O., Pories, W. J., Flickinger, E. G., Meelheim, D., & Dohm, G. L. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112958 · Cited by 341 · see citing works

Evidence Against Altered Expression of GLUT1 or GLUT4 in Skeletal Muscle of Patients With Obesity or NIDDM

Pedersen, O., Bak, J. F., Andersen, P. H., Lund, S., Moller, D. E., Flier, J. S., & Kahn, B. B. (1990) · Diabetes · doi:10.2337/diab.39.7.865 · Cited by 329 · see citing works

Expression and function of IRS-1 in insulin signal transmission.

Sun, X. J., Miralpeix, M., Myers, M. G., Glasheen, E. M., Backer, J. M., Kahn, C. R., & White, M. F. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41723-1 · Cited by 326 · see citing works

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

Rothman, D. L., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115686 · Cited by 325 · see citing works

The Role of Free Fatty Acid Metabolism in the Pathogenesis of Insulin Resistance in Obesity and Noninsulin-Dependent Diabetes Mellitus*

GROOP, L. C., SALORANTA, C., SHANK, M., BONADONNA, R. C., FERRANNINI, E., & DEFRONZO, R. A. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-96 · Cited by 312 · see citing works

Role of Hyperglucagonemia in Maintenance of Increased Rates of Hepatic Glucose Output in Type II Diabetics

Baron, A. D., Schaeffer, L., Shragg, P., & Kolterman, O. G. (1987) · Diabetes · doi:10.2337/diab.36.3.274 · Cited by 308 · see citing works

Variations in Insulin-Stimulated Glucose Uptake in Healthy Individuals with Normal Glucose Tolerance*

Hollenbeck, C. B., & Reaven, G. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-6-1169 · Cited by 306 · see citing works

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

Kerouz, N., Hörsch, D., Pons, S., & Kahn, C. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119872 · Cited by 301 · see citing works

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase

De Fea, K., & Roth, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31400 · Cited by 298 · see citing works

A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia.

Weyer, C., Hanson, R. L., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2094 · Cited by 296 · see citing works

Splanchnic and Peripheral Disposal of Oral Glucose in Man

Katz, L. D., Glickman, M. G., Rapoport, S. I., Ferrannini, E., & DeFronzo, R. A. (1983) · Diabetes · doi:10.2337/diab.32.7.675 · Cited by 287 · see citing works

SEQUENTIAL CHANGES IN SERUM INSULIN CONCENTRATION DURING DEVELOPMENT OF NON-INSULIN-DEPENDENT DIABETES

Saad, M., Pettitt, D., Mott, D., Knowler, W., Nelson, R., & Bennett, P. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92804-3 · Cited by 265 · see citing works

In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus.

Kashiwagi, A., Verso, M. A., Andrews, J., Vasquez, B., Reaven, G., & Foley, J. E. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111080 · Cited by 250 · see citing works

Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus

Campbell, P. J., Mandarino, L. J., & Gerich, J. E. (1988) · Metabolism · doi:10.1016/0026-0495(88)90023-6 · Cited by 226 · see citing works

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

Carpentier, A. C., Mittelman, S. D., Bergman, R. N., Giacca, A., & Lewis, G. F. (2000) · Diabetes · doi:10.2337/diabetes.49.3.399 · Cited by 222 · see citing works

The fourth Musketeer ? from Alexandre Dumas to Claude Bernard

Reaven, G. M. (1995) · Diabetologia · doi:10.1007/s001250050247 · Cited by 221 · see citing works

Kinetics of human connecting peptide in normal and diabetic subjects.

FABER, O. K., Hagen, C., Binder, C., Markussen, J., Naithani, V. K., BLIX, P. M., Kuzuya, H., Horwitz, D. L., Rubenstein, A. H., & Rossing, N. N. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109106 · Cited by 201 · see citing works

Effects of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism.

Mandarino, L. J., Wright, K. S., Verity, L. S., Nichols, J., Bell, J. M., Kolterman, O. G., & Beck-Nielsen, H. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113118 · Cited by 194 · see citing works

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

Freidenberg, G. R., Reichart, D. R., Olefsky, J. M., & Henry, R. R. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113744 · Cited by 194 · see citing works

Roles of Glucose Transport and Glucose Phosphorylation in Muscle Insulin Resistance of NIDDM

Bonadonna, R. C., Bonora, E., Prato, S. D., Saccomani, M. P., Cobelli, C., Natali, A., Frascerra, S., Pecori, N., Ferrannini, E., Bier, D., et al. (1996) · Diabetes · doi:10.2337/diab.45.7.915 · Cited by 191 · see citing works

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

Newgard, C. B., Brady, M. J., O'Doherty, R. M., & Saltiel, A. R. (2000) · Diabetes · doi:10.2337/diabetes.49.12.1967 · Cited by 189 · see citing works

Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake.

Thorburn, A. W., Gumbiner, B., Bulacan, F., Wallace, P., & Henry, R. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114468 · Cited by 185 · see citing works

Different aetiologies of Type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects

Arner, P., Pollare, T., & Lithell, H. (1991) · Diabetologia · doi:10.1007/bf00403284 · Cited by 184 · see citing works

Hexokinase II mRNA and gene structure, regulation by insulin, and evolution.

Printz, R. L., Koch, S. R., Potter, L. R., O'Doherty, R. M., Tiesinga, J. J., Moritz, S., & Granner, D. K. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53521-3 · Cited by 179 · see citing works

Lactate release from the subcutaneous tissue in lean and obese men.

Jansson, P., Larsson, A., Smith, U., & Lönnroth, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116951 · Cited by 159 · see citing works

Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus.

Mevorach, M., Giacca, A., Aharon, Y., Hawkins, M. A., Shamoon, H., & Rossetti, L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2720 · Cited by 142 · see citing works

Non-esterified fatty acids and the liver: why is insulin secreted into the portal vein?

Bergman, R. N. (2000) · Diabetologia · doi:10.1007/s001250051474 · Cited by 141 · see citing works

Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM

Utriainen, T., Takala, T., Luotolahti, M., Rönnemaa, T., Laine, H. K., Ruotsalainen, U., Haaparanta‐Solin, M., Nuutila, P., & Yki‐Järvinen, H. (1998) · Diabetologia · doi:10.1007/s001250050946 · Cited by 129 · see citing works

Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms.

Henry, R. R., Ciaraldi, T. P., Abrams-Carter, L., Mudaliar, S. R., Park, K., & Nikoulina, S. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118906 · Cited by 129 · see citing works

Analysis of the Signaling Pathway Involved in the Regulation of Hexokinase II Gene Transcription by Insulin

Osawa, H., Sutherland, C., Robey, R. B., Printz, R. L., & Granner, D. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16690 · Cited by 126 · see citing works

Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle

Mandarino, L. J., Printz, R. L., Cusi, K. A., Kinchington, P., O'Doherty, R. M., Osawa, H., Sewell, C., Consoli, A., Granner, D. K., & DeFronzo, R. A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.4.e701 · Cited by 124 · see citing works

Intracellular Defects in Glucose Metabolism in Obese Patients With NIDDM

Kelley, D. E., Mokan, M., & Mandarino, L. J. (1992) · Diabetes · doi:10.2337/diab.41.6.698 · Cited by 121 · see citing works

Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation

Pratipanawatr, W., Pratipanawatr, T., Cusi, K., Berria, R., Adams, J. M., Jenkinson, C. P., Maezono, K., DeFronzo, R. A., & Mandarino, L. J. (2001) · Diabetes · doi:10.2337/diabetes.50.11.2572 · Cited by 118 · see citing works

Human adipose tissue glucose uptake determined using [ 18 F]-fluoro-deoxy-glucose ([ 18 F]FDG) and PET in combination with microdialysis

Virtanen, K. A., Peltoniemi, P., Marjamäki, P., Asola, M. R., Strindberg, L., Parkkola, R. K., Huupponen, R., Knuuti, J. M., Lönnroth, P., & Nuutila, P. (2001) · Diabetologia · doi:10.1007/s001250100026 · Cited by 117 · see citing works

Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus.

Vestergaard, H., Lund, S., Larsen, F. S., Bjerrum, O. J., & Pedersen, O. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116466 · Cited by 98 · see citing works

Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals.

Avogaro, A., TOFFOLO, G. M., Miola, M., Valerio, A., Tiengo, A., Cobelli, C., & Prato, S. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118754 · Cited by 88 · see citing works

Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals

Matsuda, M., DeFronzo, R. A., Glass, L. C., Consoli, A., Giordano, M., Bressler, P., & DelPrato, S. (2002) · Metabolism · doi:10.1053/meta.2002.34700 · Cited by 85 · see citing works

Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM

Mandarino, L. J., Consoli, A., Jain, A., & Kelley, D. E. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.3.e463 · Cited by 83 · see citing works

Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus

Waldhäusl, W. K., Bratusch-Marrain, P. R., Gasic, S., Korn, A., & Nowotny, P. (1982) · Diabetologia · doi:10.1007/bf00257722 · Cited by 80 · see citing works

Normal Insulin-Receptor cDNA Sequence in Pima Indians With NIDDM

Moller, D. E., Yokota, A., & Flier, J. S. (1989) · Diabetes · doi:10.2337/diab.38.11.1496 · Cited by 76 · see citing works

Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II Diabetes

Lönnroth, P., Digirolamo, M., Krotkiewski, M., & Smith, U. (1983) · Diabetes · doi:10.2337/diab.32.8.748 · Cited by 74 · see citing works

The Regulation of Glycogen Synthase by Protein Phosphatase 1 in 3T3-L1 Adipocytes

Brady, M., Nairn, A. C., & Saltiel, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29698 · Cited by 66 · see citing works

Interactions of Impaired Glucose Transport and Phosphorylation in Skeletal Muscle Insulin Resistance

Williams, K. V., Price, J. C., & Kelley, D. E. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2069 · Cited by 61 · see citing works

NIDDM Associated With Mutation in Tyrosine Kinase Domain of Insulin Receptor Gene

Cocozza, S., Porcellini, A., Riccardi, G., Monticelli, A., Condorelli, G., Ferrara, A. M., Pianese, L., Miele, C., Capaldo, B., Bèguinot, F., et al. (1992) · Diabetes · doi:10.2337/diab.41.4.521 · Cited by 58 · see citing works

Effects of Insulin on Subcellular Localization of Hexokinase II in Human Skeletal Muscle in Vivo

Vogt, C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.1.230 · Cited by 56 · see citing works

Reciprocal Variations in Insulin-Stimulated Glucose Uptake and Pancreatic Insulin Secretion in Women With Normal Glucose Tolerance

Diamond, M. P., Thornton, K. L., Connolly-Diamond, M., Sherwin, R. S., & DeFronzo, R. A. (1995) · Journal of the Society for Gynecologic Investigation · doi:10.1016/1071-5576(95)00023-8 · Cited by 54 · see citing works

Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans

Nyomba, B. L. G., Ossowski, V., Bogardus, C., & Mott, D. M. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.6.e964 · Cited by 54 · see citing works

Glucose Ingestion Causes GLUT4 Translocation in Human Skeletal Muscle

Goodyear, L. J., Hirshman, M. F., Napoli, R., Markuns, J. F., Horton, E. S., Ljungqvist, O., & Calles, J. (1996) · Diabetes · doi:10.2337/diab.45.8.1051 · Cited by 53 · see citing works

Adipocyte glycogen synthase and pyruvate dehydrogenase in obese and type II diabetic subjects

Mandarino, L. J., Madar, Z., Kolterman, O., Bell, J., & Olefsky, J. M. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.4.e489 · Cited by 40 · see citing works

Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine

Jones, J. P., & Dohm, G. L. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.4.e682 · Cited by 39 · see citing works

Reciprocal Variations in Insulin-Stimulated Glucose Uptake and Pancreatic Insulin Secretion in Women With Normal Glucose Tolerance

Diamond, M. P., Thornton, K. L., Connolly-Diamond, M., et al. (1995) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155769500200507 · Cited by 37 · see citing works

Decreased Activation Rate of Insulin-Stimulated Glucose Transport in Adipocytes From Obese Subjects

Molina, J. M., Ciaraldi, T. P., Brady, D., & Olefsky, J. M. (1989) · Diabetes · doi:10.2337/diab.38.8.991 · Cited by 32 · see citing works

Pathogenesis of type 2 diabetes mellitus

Dostou, J. M., & Gerich, J. E. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-18577 · Cited by 31 · see citing works

Studies of the human liver insulin receptor in noninsulin-dependent diabetes mellitus.

Arner, P., Einarsson, K., Ewerth, S., & Livingston, J. N. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112492 · Cited by 29 · see citing works

A Comparison of Brain Glucose Metabolism in Diabetes as Measured by Positron Emission Tomography or by Arteriovenous Techniques

Grill, V. (1990) · Annals of Medicine · doi:10.3109/07853899009147264 · Cited by 26 · see citing works

Regulation of Muscle Glucose Uptake In Vivo

Mandarino, L. J., Bonadonna, R. C., McGuinness, O. P., Halseth, A. E., & Wasserman, D. H. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070227 · Cited by 19 · see citing works

Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy

Nyomba, B. L., Freymond, D., Raz, I., Stone, K., Mott, D. M., & Bogardus, C. (1990) · Metabolism · doi:10.1016/0026-0495(90)90096-u · Cited by 17 · see citing works

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus.

DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works

Pathogenesis of type 2 diabetes mellitus

DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342 · see citing works

Insulin resistance: a metabolic pathway to chronic liver disease

Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900 · see citing works

Pathogenesis of insulin resistance in skeletal muscle

Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works

Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents

Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535 · see citing works

Preservation of β-Cell Function: The Key to Diabetes Prevention

DeFronzo, R. A., & Abdul-Ghani, M. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0246 · Cited by 247 · see citing works

Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients

Bajaj, M., Suraamornkul, S., Romanelli, A., Cline, G. W., Mandarino, L. J., Shulman, G. I., & DeFronzo, R. A. (2005) · Diabetes · doi:10.2337/diabetes.54.11.3148 · Cited by 181 · see citing works

Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus

Abdul-Ghani, M. A., & DeFronzo, R. A. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0030-1 · Cited by 146 · see citing works

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

Abdul-Ghani, M. A., Muller, F. L., Liu, Y., Chavez, A. O., Balas, B., Zuo, P., Chang, Z., Tripathy, D., Jani, R., Molina-Carrion, M., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90287.2008 · Cited by 140 · see citing works

Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity

Liang, H., Balas, B., Tantiwong, P., Dube, J., Goodpaster, B. H., O'Doherty, R. M., DeFronzo, R. A., Richardson, A., Musi, N., & Ward, W. F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90292.2008 · Cited by 81 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works