Rastinejad, Fraydoon

Bile acid metabolites control TH17 and Treg cell differentiation

Hang, S., Paik, D., Yao, L., Kim, E., Trinath, J., Lu, J., Ha, S., Nelson, B. N., Kelly, S. P., Wu, L., et al. (2019) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,457

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

Chandra, V., Huang, P., Hamuro, Y., Raghuram, S., Wang, Y., Burris, T. P., & Rastinejad, F. (2008) · Nature

Peroxisome Proliferator-Activated ReceptorsProtein Structure and Dynamics

Cited by 808

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

Paik, D., Yao, L., Zhang, Y., Bae, S., D’Agostino, G. D., Zhang, M., Kim, E., Franzosa, E. A., Avila-Pacheco, J., Bisanz, J. E., et al. (2022) · Nature

Gut microbiota and healthInflammatory Bowel Disease

Cited by 594

Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.

Smith, S. H., Jayawickreme, C., Rickard, D. J., Nicodeme, E., Bui, T., Simmons, C., Coquery, C. M., Neil, J., Pryor, W. M., Mayhew, D., et al. (2017) · Journal of Investigative Dermatology

Psoriasis: Treatment and PathogenesisDermatology and Skin Diseases

Cited by 387

Structural integration in hypoxia-inducible factors

Wu, D., Potluri, N., Lu, J., Kim, Y., & Rastinejad, F. (2015) · Nature

Cancer, Hypoxia, and MetabolismEnzyme Structure and Function

Cited by 346

Vitamin D Binding Protein: A Historic Overview

Bouillon, R., Schuit, F., Antonio, L., & Rastinejad, F. (2020) · Frontiers in Endocrinology

Vitamin D Research StudiesProtein Interaction Studies and Fluorescence Analysis

Cited by 316

A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1

Li, W., Hang, S., Fang, Y., Bae, S., Zhang, Y., Zhang, M., Wang, G., McCurry, M. D., Bae, M., Paik, D., et al. (2021) · Cell Host & Microbe

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 306

Nuclear-receptor interactions on DNA-response elements

Khorasanizadeh, S., & Rastinejad, F. (2001) · Trends in Biochemical Sciences

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 288

Multidomain integration in the structure of the HNF-4α nuclear receptor complex

Chandra, V., Huang, P., Potluri, N., Wu, D., Kim, Y., & Rastinejad, F. (2013) · Nature

Protein Structure and DynamicsNuclear Receptors and Signaling

Cited by 206

Structural characterization of mammalian bHLH-PAS transcription factors

Wu, D., & Rastinejad, F. (2017) · Current Opinion in Structural Biology

Protein Structure and DynamicsCircadian rhythm and melatonin

Cited by 122

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

Wu, D., Su, X., Potluri, N., Kim, Y., & Rastinejad, F. (2016) · eLife

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 85

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex

Diao, X., Shang, Q., Guo, M., Huang, Y., Zhang, M., Chen, X., Liang, Y., Sun, X., Zhou, F., Zhuang, J., et al. (2025) · Nature communications

Toxic Organic Pollutants ImpactProtein Structure and Dynamics

Cited by 72

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Cheng, X., Prange-Barczynska, M., Fielding, J. W., Zhang, M., Burrell, A. L., Lima, J. D. C. C., Eckardt, L., Argles, I. L. A., Pugh, C. W., Buckler, K. J., et al. (2020) · Journal of Clinical Investigation

Neuroscience of respiration and sleepCancer, Hypoxia, and Metabolism

Cited by 62

Identification of oleoylethanolamide as an endogenous ligand for HIF-3α

Diao, X., Ye, F., Zhang, M., Ren, X., Tian, X., Lu, J., Sun, X., Hou, Z., Chen, X., Li, F., et al. (2022) · Nature Communications

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 51

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family

Sun, X., Jing, L., Li, F., Zhang, M., Diao, X., Zhuang, J., Rastinejad, F., & Wu, D. (2022) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 32