Wiley, Christopher D.

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Wiley, C. D., Velarde, M. C., Lecot, P., Liu, S., Sarnoski, E. A., Freund, A., Shirakawa, K., Lim, H. W., Davis, S. S., Ramanathan, A., et al. (2016) · Cell Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,275

The metabolic roots of senescence: mechanisms and opportunities for intervention

Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 691

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

Wiley, C. D., & Campisi, J. (2016) · Cell Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 440

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Covarrubias, A. J., Kale, A., Perrone, R., Lopez-Dominguez, J. A., Pisco, A. O., Kasler, H. G., Schmidt, M. S., Heckenbach, I., Kwok, R., Wiley, C. D., et al. (2020) · Nature Metabolism

Sirtuins and Resveratrol in MedicineTelomeres, Telomerase, and Senescence

Cited by 420

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S., & Campisi, J. (2017) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 234

Context-dependent effects of cellular senescence in cancer development.

Lecot, P., Alimirah, F., Desprez, P.-Y., Campisi, J., & Wiley, C. (2016) · British Journal of Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 183

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

Wiley, C. D., Sharma, R., Davis, S. S., Lopez-Dominguez, J. A., Mitchell, K. P., Wiley, S., Alimirah, F., Kim, D. E., Payne, T., Rosko, A., et al. (2021) · Cell Metabolism

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 173

Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells

Perrott, K. M., Wiley, C. D., Desprez, P.-Y., & Campisi, J. (2017) · GeroScience

Flavonoids in Medical ResearchTelomeres, Telomerase, and Senescence

Cited by 163

SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

Wiley, C. D., Liu, S., Limbad, C., Zawadzka, A. M., Beck, J., Demaria, M., Artwood, R., Alimirah, F., Lopez-Dominguez, J.-A., Kuehnemann, C., et al. (2019) · Cell Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 137

Disease drivers of aging

Hodes, R. J., Sierra, F., Austad, S. N., Epel, E., Neigh, G. N., Erlandson, K. M., Schafer, M. J., LeBrasseur, N. K., Wiley, C., Campisi, J., et al. (2016) · Annals of the New York Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 132

Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling

Alimirah, F., Pulido, T., Valdovinos, A., Alptekin, S., Chang, E., Jones, E., Diaz, D. A., Flores, J., Velarde, M. C., Demaria, M., et al. (2020) · Cancer Research

Telomeres, Telomerase, and SenescenceSkin Protection and Aging

Cited by 128

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

Wiley, C. D., Schaum, N., Alimirah, F., Lopez-Dominguez, J. A., Orjalo, A. V., Scott, G., Desprez, P.-Y., Benz, C., Davalos, A. R., & Campisi, J. (2018) · Scientific Reports

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 124