Medema, René H.

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature

FOXO transcription factor regulationRedox biology and oxidative stress

Cited by 1,580

The cohesin release factor WAPL restricts chromatin loop extension

Haarhuis, J. H. I., van der Weide, R. H., Blomen, V. A., Yáñez-Cuna, J. O., Amendola, M., van Ruiten, M. S., Krijger, P. H. L., Teunissen, H., Medema, R. H., van Steensel, B., et al. (2017) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 793

Shared and separate functions of polo-like kinases and aurora kinases in cancer

Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer

Microtubule and mitosis dynamicsHeterocyclic Compound Synthesis and Bioactivity

Cited by 597

FoxO3a Transcriptional Regulation of Bim Controls Apoptosis in Paclitaxel-treated Breast Cancer Cell Lines

Sunters, A., Fernández de Mattos, S., Stahl, M., Brosens, J. J., Zoumpoulidou, G., Saunders, C. A., Coffer, P. J., Medema, R. H., Coombes, R. C., & Lam, E. W.-F. (2003) · Journal of Biological Chemistry

FOXO transcription factor regulationCell death mechanisms and regulation

Cited by 505

Growth suppression by p16ink4 requires functional retinoblastoma protein

Medema, R. H., Herrera, R. E., Lam, F., & Weinberg, R. A. (1995) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 433

Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment

Jelluma, N., Brenkman, A. B., van den Broek, N. J. F., Cruijsen, C. W. A., van Osch, M. H. J., Lens, S. M. A., Medema, R. H., & Kops, G. J. P. L. (2008) · Cell

Microtubule and mitosis dynamicsDNA Repair Mechanisms

Cited by 294

The core spliceosome as target and effector of non-canonical ATM signalling

Tresini, M., Warmerdam, D. O., Kolovos, P., Snijder, L., Vrouwe, M. G., Demmers, J. A. A., van IJcken, W. F. J., Grosveld, F. G., Medema, R. H., Hoeijmakers, J. H. J., et al. (2015) · Nature

RNA Research and SplicingDNA Repair Mechanisms

Cited by 252

Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery

Mamely, I., van Vugt, M. A., Smits, V. A., Semple, J. I., Lemmens, B., Perrakis, A., Medema, R. H., & Freire, R. (2006) · Current Biology

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 227

p21 Inhibits Thr161 Phosphorylation of Cdc2 to Enforce the G2 DNA Damage Checkpoint

Smits, V. A. J., Klompmaker, R., Vallenius, T., Rijksen, G., Mäkelä, T. P., & Medema, R. H. (2000) · Journal of Biological Chemistry

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 221

Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence

Krenning, L., Feringa, F. M., Shaltiel, I. A., van den Berg, J., & Medema, R. H. (2014) · Molecular Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 193

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

Kleiblova, P., Shaltiel, I. A., Benada, J., Ševčík, J., Pecháčková, S., Pohlreich, P., Voest, E. E., Dundr, P., Bartek, J., Kleibl, Z., et al. (2013) · Journal of Cell Biology

Cancer-related Molecular PathwaysProtein Tyrosine Phosphatases

Cited by 170

p21waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA-replication or stress-activated kinases

Medema, R. H., Klompmaker, R., Smits, V. A., & Rijksen, G. (1998) · Oncogene

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 161

A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases

Tanenbaum, M. E., Macurek, L., van der Vaart, B., Galli, M., Akhmanova, A., & Medema, R. H. (2011) · Current Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 148

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Macedo, J. C., Vaz, S., Bakker, B., Ribeiro, R., Bakker, P. L., Escandell, J. M., Ferreira, M. G., Medema, R., Foijer, F., & Logarinho, E. (2018) · Nature Communications

Telomeres, Telomerase, and SenescenceMicrotubule and mitosis dynamics

Cited by 131

Novel functions of FoxM1: from molecular mechanisms to cancer therapy

Alvarez-Fernández, M., & Medema, R. H. (2013) · Frontiers in Oncology

FOXO transcription factor regulationCancer-related Molecular Pathways

Cited by 85

WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy

Haarhuis, J. H. I., Elbatsh, A. M. O., van den Broek, B., Camps, D., Erkan, H., Jalink, K., Medema, R. H., & Rowland, B. D. (2013) · Current Biology

Microtubule and mitosis dynamicsDNA Repair Mechanisms

Cited by 84

Wip1 confers G2 checkpoint recovery competence by counteracting p53‐dependent transcriptional repression

Lindqvist, A., de Bruijn, M., Macurek, L., Brás, A., Mensinga, A., Bruinsma, W., Voets, O., Kranenburg, O., & Medema, R. H. (2009) · The EMBO Journal

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 75

Mitogen requirement for cell cycle progression in the absence of pocket protein activity

Foijer, F., Wolthuis, R. M. F., Doodeman, V., Medema, R. H., & te Riele, H. (2005) · Cancer Cell

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 53