Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

Kleiblova, Petra; Shaltiel, Indra A.; Benada, Jan; &#x8a;evčík, Jan; Pecháčková, Soňa; Pohlreich, Petr; Voest, Emile E.; Dundr, Pavel; Bartek, Jiri; Kleibl, Zdenek; Medema, René H.; Macurek, Libor

doi:10.1083/jcb.201210031

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an intrinsic barrier preventing cancer development. The serine/threonine phosphatase PPM1D/Wip1 inactivates p53 and promotes termination of the DDR p…