Groop, Leif

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Platform, B. G., Flannick, J., DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, et al. (2019) · Nature

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 304

Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins

Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J., Beck-Nielsen, H., Groop, L., & Vaag, A. (2004) · Journal of Clinical Investigation

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 300

Plasma Copeptin and the Risk of Diabetes Mellitus

Enhörning, S., Wang, T. J., Nilsson, P. M., Almgren, P., Hedblad, B., Berglund, G., Struck, J., Morgenthaler, N. G., Bergmann, A., Lindholm, E., et al. (2010) · Circulation

Electrolyte and hormonal disordersDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 299

Increased melatonin signaling is a risk factor for type 2 diabetes

Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A.-K., et al. (2016) · Cell Metabolism

Pancreatic function and diabetesCircadian rhythm and melatonin

Cited by 262

Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes

Rosengren, A. H., Braun, M., Mahdi, T., Andersson, S. A., Travers, M. E., Shigeto, M., Zhang, E., Almgren, P., Ladenvall, C., Axelsson, A. S., et al. (2012) · Diabetes

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 237

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., et al. (2010) · Human Molecular Genetics

Genetic Associations and EpidemiologyHormonal and reproductive studies

Cited by 217

The Diabetes Susceptibility Gene Clec16a Regulates Mitophagy

Soleimanpour, S. A., Gupta, A., Bakay, M., Ferrari, A. M., Groff, D. N., Fadista, J., Spruce, L. A., Kushner, J. A., Groop, L., Seeholzer, S. H., et al. (2014) · Cell

Pancreatic function and diabetesAutophagy in Disease and Therapy

Cited by 211

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

Fall, T., Hägg, S., Mägi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, A.-P., Thorleifsson, G., Ladenvall, C., Kals, M., et al. (2013) · PLoS Medicine

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 203

Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health

Strausz, S., Ruotsalainen, S., Ollila, H. M., Karjalainen, J., Kiiskinen, T., Reeve, M., Kurki, M., Mars, N., Havulinna, A. S., Luonsi, E., et al. (2021) · European Respiratory Journal

Obstructive Sleep Apnea ResearchGenetic Associations and Epidemiology

Cited by 194

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

Rönn, T., Poulsen, P., Hansson, O., Holmkvist, J., Almgren, P., Nilsson, P., Tuomi, T., Isomaa, B., Groop, L., Vaag, A., et al. (2008) · Diabetologia

Epigenetics and DNA MethylationMetabolism, Diabetes, and Cancer

Cited by 175

Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes

Mansour Aly, D., Dwivedi, O. P., Prasad, R. B., Käräjämäki, A., Hjort, R., Thangam, M., Åkerlund, M., Mahajan, A., Udler, M. S., Florez, J. C., et al. (2021) · Nature Genetics

Genetic Associations and EpidemiologyDiabetes and associated disorders

Cited by 172

Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells

Zhang, E., Mohammed Al-Amily, I., Mohammed, S., Luan, C., Asplund, O., Ahmed, M., Ye, Y., Ben-Hail, D., Soni, A., Vishnu, N., et al. (2019) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 171

Genetics of Type 2 Diabetes

Ahlqvist, E., Ahluwalia, T. S., & Groop, L. (2011) · Clinical Chemistry

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 166

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

Viñuela, A., Varshney, A., van de Bunt, M., Prasad, R. B., Asplund, O., Bennett, A., Boehnke, M., Brown, A. A., Erdos, M. R., Fadista, J., et al. (2020) · Nature Communications

Genetic Associations and EpidemiologyPancreatic function and diabetes

Cited by 152

Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans

Bonadonna, R. C., Groop, L. C., Zych, K., Shank, M., & DeFronzo, R. A. (1990) · American Journal of Physiology-Endocrinology and Metabolism

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 149

Impaired Activation of Glycogen Synthase in People at Increased Risk for Developing NIDDM

Schalin-Jäntti, C., Härkönen, M., & Groop, L. C. (1992) · Diabetes

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 142

The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes

Abdul‐Ghani, M. A., Lyssenko, V., Tuomi, T., DeFronzo, R. A., & Groop, L. (2010) · Diabetes/Metabolism Research and Reviews

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 139

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

Flannick, J., Beer, N. L., Bick, A. G., Agarwala, V., Molnes, J., Gupta, N., Burtt, N. P., Florez, J. C., Meigs, J. B., Taylor, H., et al. (2013) · Nature Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 136

Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

Andersson, S. A., Olsson, A. H., Esguerra, J. L. S., Heimann, E., Ladenvall, C., Edlund, A., Salehi, A., Taneera, J., Degerman, E., Groop, L., et al. (2012) · Molecular and Cellular Endocrinology

Pancreatic function and diabetesCellular transport and secretion

Cited by 122

Insulin resistance in Type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle

Eriksson, J., Koranyi, L., Bourey, R., Schalin-J�ntti, C., Wid�n, E., Mueckler, M., Permutt, A. M., & Groop, L. C. (1992) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 122

Insights Into the Molecular Mechanism for Type 2 Diabetes Susceptibility at the KCNQ1 Locus From Temporal Changes in Imprinting Status in Human Islets

Travers, M. E., Mackay, D. J. G., Dekker Nitert, M., Morris, A. P., Lindgren, C. M., Berry, A., Johnson, P. R., Hanley, N., Groop, L. C., McCarthy, M. I., et al. (2013) · Diabetes

Genetic Syndromes and ImprintingPancreatic function and diabetes

Cited by 118

γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetes

Taneera, J., Jin, Z., Jin, Y., Muhammed, S. J., Zhang, E., Lang, S., Salehi, A., Korsgren, O., Renström, E., Groop, L., et al. (2012) · Diabetologia

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 117

Absence of islet autoantibodies and modestly raised glucose values at diabetes diagnosis should lead to testing for MODY: lessons from a 5-year pediatric Swedish National Cohort Study

Carlsson, A., Shepherd, M., Ellard, S., Weedon, M., Lernmark, Å., Forsander, G., Colclough, K., Brahimi, Q., Valtonen-Andre, C., Ivarsson, S. A., et al. (2020) · Diabetes Care

Diabetes and associated disordersPancreatic function and diabetes

Cited by 111

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

Koeck, T., Olsson, A. H., Nitert, M. D., Sharoyko, V. V., Ladenvall, C., Kotova, O., Reiling, E., Rönn, T., Parikh, H., Taneera, J., et al. (2011) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 105