Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works

<i>EGFR</i> Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

Kobayashi, S., Boggon, T. J., Dayaram, T., Jänne, P. A., Kocher, O., Meyerson, M., Johnson, B. E., Eck, M. J., Tenen, D. G., & Halmos, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa044238 · Cited by 3,964 · see citing works

Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

Pao, W., Miller, V. A., Politi, K. A., Riely, G. J., Somwar, R., Zakowski, M. F., Kris, M. G., & Varmus, H. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020073 · Cited by 3,527 · cited 1× · see citing works

Phase III Study of Afatinib or Cisplatin Plus Pemetrexed in Patients With Metastatic Lung Adenocarcinoma With <i>EGFR</i> Mutations

Sequist, L. V., Yang, J. C.-H., Yamamoto, N., O'Byrne, K., Hirsh, V., Mok, T., Geater, S. L., Orlov, S., Tsai, C.-M., Boyer, M., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.44.2806 · Cited by 3,228 · see citing works

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers

Shigematsu, H., Lin, L., Takahashi, T., Nomura, M., Suzuki, M., Wistuba, I. I., Fong, K. M., Lee, H., Toyooka, S., Shimizu, N., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji055 · Cited by 2,377 · see citing works

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

Cross, D. A. E., Ashton, S. E., Ghiorghiu, S., Eberlein, C., Nebhan, C. A., Spitzler, P. J., Orme, J. P., Finlay, M. R. V., Ward, R. A., Mellor, M. J., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0337 · Cited by 2,246 · see citing works

AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer

Jänne, P. A., Yang, J. C.-H., Kim, D.-W., Planchard, D., Ohe, Y., Ramalingam, S. S., Ahn, M.-J., Kim, S.-W., Su, W.-C., Horn, L., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1411817 · Cited by 2,116 · see citing works

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Shaw, R. J., Kosmatka, M., Bardeesy, N., Hurley, R. L., Witters, L. A., DePinho, R. A., & Cantley, L. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308061100 · Cited by 1,797 · see citing works

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., & Ullrich, A. (1999) · Nature · doi:10.1038/47260 · Cited by 1,507 · see citing works

Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma

Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

Daaka, Y., Luttrell, L. M., & Lefkowitz, R. J. (1997) · Nature · doi:10.1038/36362 · Cited by 1,278 · see citing works

LKB1 modulates lung cancer differentiation and metastasis

Ji, H., Ramsey, M. R., Hayes, D. N., Fan, C., McNamara, K., Kozlowski, P., Torrice, C., Wu, M. C., Shimamura, T., Perera, S. A., et al. (2007) · Nature · doi:10.1038/nature06030 · Cited by 1,064 · see citing works

Protein Kinase C Contains a Pseudosubstrate Prototope in Its Regulatory Domain

House, C. M., & Kemp, B. E. (1987) · Science · doi:10.1126/science.3686012 · Cited by 1,008 · see citing works

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 972 · see citing works

The sympathetic nervous system induces a metastatic switch in primary breast cancer

Sloan, E. K., Priceman, S. J., Cox, B. F., Yu, S., Pimentel, M. A., Tangkanangnukul, V., Arevalo, J. M. G., Morizono, K., Karanikolas, B. D. W., Wu, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0522 · Cited by 930 · see citing works

The BATTLE Trial: Personalizing Therapy for Lung Cancer

Kim, E. S., Herbst, R. S., Wistuba, I. I., Lee, J. J., Blumenschein, G. R., Tsao, A. S., Stewart, D. J., Hicks, M. E., Erasmus, J. J., Gupta, S. K., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0010 · Cited by 888 · see citing works

Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small Cell Lung Cancer

Engelman, J. A., & Janne, P. A. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2248 · Cited by 706 · see citing works

STK11/LKB1 deficiency promotes neutrophil recruitment and proinflammatory cytokine production to suppress T-cell activity in the lung tumor microenvironment

Koyama, S., Akbay, E. A., Li, Y. Y., Aref, A. R., Skoulidis, F., Herter-Sprie, G. S., Buczkowski, K. A., Liu, Y., Awad, M. M., Denning, W. L., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1439 · Cited by 640 · see citing works

Beta Blockers and Breast Cancer Mortality: A Population- Based Study

Barron, T. I., Connolly, R. M., Sharp, L., Bennett, K., & Visvanathan, K. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.5422 · Cited by 532 · see citing works

Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways

Arbiser, J. L., Moses, M. A., Fernández, C. A., Ghiso, N., Cao, Y., Klauber, N., Frank, D. A., Brownlee, M., Flynn, E. A., Parangi, S., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.861 · Cited by 466 · see citing works

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

Hara, M. R., Kovacs, J. J., Whalen, E. J., Rajagopal, S., Strachan, R. T., Grant, W., Towers, A. J., Williams, B., Lam, C. M., Xiao, K., et al. (2011) · Nature · doi:10.1038/nature10368 · Cited by 420 · see citing works

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

Hausdorff, W. P., Bouvier, M., O’Dowd, B. F., Irons, G. P., Caron, M. G., & Lefkowitz, R. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63907-9 · Cited by 414 · see citing works

TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

Yao, Z., Fenoglio, S., Gao, D. C., Camiolo, M., Stiles, B., Lindsted, T., Schlederer, M., Johns, C., Altorki, N., Mittal, V., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009472107 · Cited by 389 · see citing works

Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

Zheng, B., Jeong, J. H., Asara, J. M., Yuan, Y.-Y., Granter, S. R., Chin, L., & Cantley, L. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.026 · Cited by 355 · see citing works

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms10634 · Cited by 354 · see citing works

Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines.

Lutgendorf, S. K., Cole, S. W., Costanzo, E. S., Bradley, S., Coffin, J. E., Jabbari, S., Rainwater, K. K., Ritchie, J. M., Yang, M., & Sood, A. K. (2003) · PubMed · Cited by 326 · see citing works

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Ercan, D., Xu, C., Yanagita, M., Monast, C. S., Pratilas, C. A., Montero, J., Butaney, M., Shimamura, T., Sholl, L., Ivanova, E. V., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0103 · Cited by 294 · see citing works

Phase III Trial of Vandetanib Compared With Erlotinib in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer

Natale, R. B., Thongprasert, S., Greco, F. A., Thomas, M., Tsai, C., Sunpaweravong, P., Ferry, D. R., Mulatero, C., Whorf, R. C., Thompson, J., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.5981 · Cited by 290 · see citing works

A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non–Small Cell Lung Cancer Patients

Tang, H., Xiao, G., Behrens, C., Schiller, J. H., Allen, J., Chow, C.-W. B., Suraokar, M. B., Corvalán, A. H., Mao, J., White, M. A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2321 · Cited by 282 · see citing works

Psychological distress and cancer mortality

Hamer, M., Chida, Y., & Molloy, G. J. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.11.002 · Cited by 282 · see citing works

Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation

Sindhu, S. T. A. K., Thomas, R., Kochumon, S., Devarajan, S., Behbehani, K., & Ahmad, R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133494 · Cited by 267 · see citing works

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

Lim, S., Li, C., Xia, W., Lee, H., Chang, S.-S., Shen, J., Hsu, J. L., Raftery, D., Djukovic, D., Gu, H., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2478 · Cited by 263 · see citing works

Computational identification of gene–social environment interaction at the human <i>IL6</i> locus

Cole, S. W., Arevalo, J. M. G., Takahashi, R., Sloan, E. K., Lutgendorf, S. K., Sood, A. K., Sheridan, J. F., & Seeman, T. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911515107 · Cited by 256 · see citing works

Non-parametric quantification of protein lysate arrays

Hu, J., He, X., Baggerly, K., Coombes, K. R., Hennessy, B. T., & Mills, G. B. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm283 · Cited by 224 · see citing works

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR -Mutant Lung Cancer

Tricker, E. M., Xu, C., Uddin, S., Capelletti, M., Ercan, D., Ogino, A., Pratilas, C. A., Rosen, N. X., Gray, N. S., Wong, K., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0063 · Cited by 207 · see citing works

Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy

Wang, H. M., Liao, Z. X., Komaki, R. U., Welsh, J. W., OʼReilly, M., Chang, J. Y., Zhuang, Y., Levy, L. B., Lu, C., & Gomez, D. R. (2013) · Annals of Oncology · doi:10.1093/annonc/mds616 · Cited by 202 · see citing works

Epac and Phospholipase Cϵ Regulate Ca2+ Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

Oestreich, E. A., Malik, S., Goonasekera, S. A., Blaxall, B. C., Kelley, G. G., Dirksen, R. T., & Smrcka, A. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806994200 · Cited by 200 · see citing works

The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid.

Schuller, H. M., Tithof, P. K., Williams, M., & Plummer, H. K. (1999) · PubMed · Cited by 189 · see citing works

Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice

Sheridan, J. F., Feng, N., Bonneau, R. H., Allen, C. M., Huneycutt, B. S., & Glaser, R. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90046-a · Cited by 173 · see citing works

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

Koivunen, J. P., Kim, J., Lee, J., Rogers, A. M., Park, J. O., Zhao, X., Naoki, K., Okamoto, I., Nakagawa, K., Yeap, B. Y., et al. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604469 · Cited by 165 · see citing works

IL ‐6 in diabetes and cardiovascular complications

Qu, D. C., Liu, J., Lau, C. W., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12713 · Cited by 162 · see citing works

Stress Hormones Regulate Interleukin-6 Expression by Human Ovarian Carcinoma Cells through a Src-dependent Mechanism

Nilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158 · see citing works

β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines

Madden, K. S., Szpunar, M. J., & Brown, E. B. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1348-y · Cited by 156 · see citing works

Use of β‐blockers is associated with prostate cancer‐specific survival in prostate cancer patients on androgen deprivation therapy

Grytli, H. H., Fagerland, M. W., Fosså, S. D., Taskén, K. A., & Håheim, L. L. (2012) · The Prostate · doi:10.1002/pros.22564 · Cited by 144 · see citing works

Changes in sympathetic nerve activity of the mammalian ovary during a normal estrous cycle and in polycystic ovary syndrome: Studies on norepinephrine release

Lara, H. E., Dorfman, M. D., Venegas, M., Luza, S. M., Luna, S. L., Mayerhofer, A., Guimarães, M. A. D. B. V., Silva, A. A. M. R. E., & RAMIREZ, V. D. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10229 · Cited by 122 · see citing works

Reciprocal Regulation of c-Src and STAT3 in Non-Small Cell Lung Cancer

Byers, L. A., Sen, B., Saigal, B., Diao, L., Wang, J., Nanjundan, M., Cascone, T., Mills, G. B., Heymach, J. V., & Johnson, F. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0767 · Cited by 119 · see citing works

Epac- and Ca2+-controlled Activation of Ras and Extracellular Signal-regulated Kinases by Gs-coupled Receptors

Keiper, M., Stope, M. B., Szatkowski, D., Böhm, A., Tysack, K., Dorp, F. V., Saur, O., Weernink, P. A. O., Evellin, S., Jakobs, K. H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403604200 · Cited by 106 · see citing works

NNK activates ERK1/2 and CREB/ATF‐1 via β‐1‐AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells

Laag, E. M., Majidi, M., Cekanova, M., Masi, T. J., Takahashi, T., & Schuller, H. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.21987 · Cited by 90 · see citing works

LKB1 Loss Induces Characteristic Patterns of Gene Expression in Human Tumors Associated with NRF2 Activation and Attenuation of PI3K-AKT

Kaufman, J. M., Amann, J. M., Park, K., Arasada, R. R., Li, H., Shyr, Y., & Carbone, D. P. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000173 · Cited by 87 · see citing works

Smoking Status Effect on Inflammatory Markers in a Randomized Trial of Current and Former Heavy Smokers

Aldaham, S. A., Foote, J. A., Chow, H. ‐. S., & Hakim, I. A. (2015) · International Journal of Inflammation · doi:10.1155/2015/439396 · Cited by 86 · see citing works

Effects of adrenaline in human colon adenocarcinoma HT-29 cells

Wong, H. P. S., Ho, J. W. C., Koo, M. W. L., Yu, L., Wu, W. K. K., Lam, E. K. Y., Tai, E. K. K., Ko, J. K.-S., Shin, V. Y., Chu, K., et al. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.04.007 · Cited by 77 · see citing works

Norepinephrine Stimulates Pancreatic Cancer Cell Proliferation, Migration and Invasion Via ß-Adrenergic Receptor-Dependent Activation of P38/MAPK Pathway

Huang, X., Wang, H., Zhou, Y. M., Huang, J. J., & Zheng, Q. (2011) · Hepatogastroenterology · doi:10.5754/hge11476 · Cited by 74 · see citing works

β-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: Implications for individuals with preexisting chronic lung disease

Park, P. G. (1995) · Lung Cancer · doi:10.1016/0169-5002(96)84221-8 · Cited by 74 · see citing works

Direct Demonstration of Impaired Functionality of a Purified Desensitized β-Adrenergic Receptor in a Reconstituted System

Strulovici, B., Cerione, R. A., Kilpatrick, B. F., Caron, M. G., & Lefkowitz, R. J. (1984) · Science · doi:10.1126/science.6089331 · Cited by 71 · see citing works

Proteomic Profiling Identifies Pathways Dysregulated in Non-small Cell Lung Cancer and an Inverse Association of AMPK and Adhesion Pathways with Recurrence

Nanjundan, M., Byers, L. A., Carey, M. S., Siwak, D. R., Raso, M. G., Diao, L., Wang, J., Coombes, K. R., Roth, J. A., Mills, G. B., et al. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181f2a266 · Cited by 70 · see citing works

Social Stress Promotes and γ-Aminobutyric Acid Inhibits Tumor Growth in Mouse Models of Non–Small Cell Lung Cancer

Al-Wadei, H. A. N., Plummer, H. K., Ullah, M. F., Unger, B. L., Brody, J. R., & Schuller, H. M. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0177 · Cited by 67 · see citing works

GPCRs and EGFR – Cross-talk of membrane receptors in cancer

Köse, M. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.07.002 · Cited by 64 · see citing works

Ligand-independent and EGF receptor-supported transactivation: Lessons from β2-adrenergic receptor signalling

Drube, S., Stirnweiss, J., Valkova, C., & Liebmann, C. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.01.003 · Cited by 61 · see citing works

Release of Norepinephrine from Human Ovary: Coupling to Steroidogenic Response

Lara, H. E., Arnaldo Porcile, J., Espinoza, J., Romero, C., Luza, S. M., Fuhrer, J., Miranda, C., & Roblero, L. S. (2001) · Endocrine · doi:10.1385/endo:15:2:187 · Cited by 49 · see citing works

Beta-endorphin and catecholamine concentrations during chronic and acute stress in intensive care patients.

Schmidt, C., & Kraft, K. (1996) · PubMed · Cited by 48 · see citing works

LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin

Memmott, R. M., & Dennis, P. A. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.25.3963 · Cited by 44 · see citing works

Regulation of nonsmall‐cell lung cancer stem cell like cells by neurotransmitters and opioid peptides

Banerjee, J., John, A. M. P., & Schuller, H. M. (2015) · International Journal of Cancer · doi:10.1002/ijc.29646 · Cited by 44 · see citing works

Further data on beta-blockers and cancer risk: observational study and meta-analysis of randomized clinical trials

Monami, M., Filippi, L., Ungar, A., Sgrilli, F., Antenore, A., Dicembrini, I., Bagnoli, P., Marchionni, N., Rotella, C. M., & Mannucci, E. (2013) · Current Medical Research and Opinion · doi:10.1185/03007995.2013.772505 · Cited by 40 · see citing works

Adrenaline induces chemoresistance in HT-29 colon adenocarcinoma cells

Yao, H., Duan, Z., Wang, M., Awonuga, A. O., Rappolee, D. A., & Xie, Y. (2009) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2008.12.009 · Cited by 37 · see citing works

5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes

Tsuchiya, Y., Denison, F. C., Heath, R. B., Carling, D., & Saggerson, D. (2011) · Bioscience Reports · doi:10.1042/bsr20110076 · Cited by 11 · see citing works

Mechanisms and clinical activity of an EGFR and HER2 exon 20–selective kinase inhibitor in non–small cell lung cancer

Robichaux, J. P., Elamin, Y. Y., Tan, Z., Carter, B. W., Zhang, S., Liu, S., Li, S., Chen, T., Poteete, A., Estrada-Bernal, A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0007-9 · Cited by 468 · see citing works

Landscape of EGFR-Dependent and -Independent Resistance Mechanisms to Osimertinib and Continuation Therapy Beyond Progression in <i>EGFR</i> -Mutant NSCLC

Le, X., Puri, S., Negrao, M. V., Nilsson, M. B., Robichaux, J., Boyle, T., Hicks, J. K., Lovinger, K. L., Roarty, E., Rinsurongkawong, W., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1542 · Cited by 387 · see citing works

Neurotransmitters: emerging targets in cancer

Jiang, S., Hu, L.-P., Wang, X., Li, J., & Zhang, Z. (2019) · Oncogene · doi:10.1038/s41388-019-1006-0 · Cited by 236 · see citing works

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

Wu, V. H., Yeerna, H., Nohata, N., Chiou, J., Harismendy, O., Raimondi, F., Inoue, A., Russell, R. B., Tamayo, P., & Gutkind, J. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.005601 · Cited by 177 · see citing works

A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

Nilsson, M. B., Sun, H., Robichaux, J., Pfeifer, M., McDermott, U., Travers, J., Diao, L., Xi, Y., Tong, P., Shen, L., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4589 · Cited by 177 · see citing works

Role of the nervous system in cancers: a review

Wang, H., Zheng, Q., Lu, Z., Wang, L., Ding, L., Xia, L., Zhang, H., Wang, M., Chen, Y.-C., & Li, G. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00450-y · Cited by 165 · see citing works

Association between pretreatment emotional distress and immune checkpoint inhibitor response in non-small-cell lung cancer

Zeng, Y.-Y., Hu, C.-H., Li, Y.-Z., Zhou, J.-S., Wang, S.-X., Liu, M.-D., Qiu, Z.-H., Deng, C., Ma, F., Xia, C., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02929-4 · Cited by 159 · see citing works

IL6 Mediates Suppression of T- and NK-cell Function in EMT-associated TKI-resistant EGFR-mutant NSCLC

Patel, S. A., Nilsson, M. B., Yang, Y., Le, X., Tran, H. T., Elamin, Y. Y., Yu, X., Zhang, F., Poteete, A., Ren, X., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-3379 · Cited by 121 · see citing works

CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

Nilsson, M. B., Yang, Y., Heeke, S., Patel, S. A., Poteete, A., Udagawa, H., Elamin, Y. Y., Moran, C. A., Kashima, Y., Arumugam, T., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.007 · Cited by 107 · see citing works

Catecholamines contribute to the neovascularization of lung cancer via tumor-associated macrophages

Xia, Y., Wei, Y., Li, Z.-Y., Cai, X.-Y., Zhang, L.-L., Dong, X.-R., Zhang, S., Zhang, R.-G., Meng, R., Zhu, F., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.004 · Cited by 103 · see citing works

Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies

Santarpía, M., Aguilar, A., CHAIB-OUKADOUR, I., Cardona, A. F., Fancelli, S., Laguía, F., Bracht, J. W. P., Cao, P., Molina‐Vila, M. Á., Karachaliou, N., et al. (2020) · Cancers · doi:10.3390/cancers12061475 · Cited by 100 · see citing works

Chronic Stress Effects on Tumor: Pathway and Mechanism

Hong, H., Ji, M. J., & Lai, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738252 · Cited by 95 · see citing works

Chronic Stress: Impacts on Tumor Microenvironment and Implications for Anti-Cancer Treatments

Tian, W., Liu, Y., Cao, C., Zeng, Y., Pan, Y., Liu, X., Peng, Y., & Wu, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.777018 · Cited by 89 · see citing works

Cell plasticity in cancer cell populations

Shen, S., & Clairambault, J. (2020) · F1000Research · doi:10.12688/f1000research.24803.1 · Cited by 86 · see citing works

The Impact of Beta Blockers on Survival Outcomes in Patients With Non–small-cell Lung Cancer Treated With Immune Checkpoint Inhibitors

Oh, M. S., Guzner, A., Wainwright, D. A., Mohindra, N. A., Chae, Y. K., Behdad, A., & Villaflor, V. M. (2020) · Clinical Lung Cancer · doi:10.1016/j.cllc.2020.07.016 · Cited by 84 · see citing works

β-Adrenergic Signaling in Lung Cancer: A Potential Role for Beta-Blockers

Nilsson, M. B., Le, X., & Heymach, J. V. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09891-w · Cited by 77 · see citing works

Chronic stress in solid tumor development: from mechanisms to interventions

Yan, J., Chen, Y., Luo, M., Hu, X., Li, H., Liu, Q., & Zou, Z. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00903-9 · Cited by 84 · see citing works

Altered Regulation of HIF-1α in Naive- and Drug-Resistant EGFR-Mutant NSCLC: Implications for a Vascular Endothelial Growth Factor-Dependent Phenotype

Nilsson, M. B., Robichaux, J. P., Herynk, M. H., Cascone, T., Le, X., Elamin, Y. Y., Patel, S. A., Zhang, F., Xu, L., Hu, L., et al. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.11.022 · Cited by 75 · see citing works

Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors

Sambrooks, C. L., Baro, M., Quijano, A., Narayan, A., Cui, W., Greninger, P., Egan, R. K., Patel, A. A., Benes, C. H., Saltzman, W. M., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0505 · Cited by 74 · see citing works

Exosomes deliver lncRNA DARS-AS1 siRNA to inhibit chronic unpredictable mild stress-induced TNBC metastasis

Liu, X., Zhang, G., Yu, T., He, J., Liu, J., Chai, X., Zhao, G., Yin, D., & Zhang, C. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215781 · Cited by 72 · see citing works

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

Zhou, J., Liu, Z., Zhang, L., Hu, X., Wang, Z., Ni, H., Wang, Y., & Qin, J. (2020) · Cancer Research and Treatment · doi:10.4143/crt.2019.510 · Cited by 61 · see citing works

Psychological distress and eustress in cancer and cancer treatment: Advances and perspectives

Wu, Y., Zhou, L., Zhang, X., Yang, X., Niedermann, G., & Xue, J. (2022) · Science Advances · doi:10.1126/sciadv.abq7982 · Cited by 63 · see citing works

Structural Insights into Characterizing Binding Sites in Epidermal Growth Factor Receptor Kinase Mutants

Zhao, Z., Xie, L., & Bourne, P. E. (2018) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.8b00458 · Cited by 58 · see citing works

Tumour–brain crosstalk restrains cancer immunity via a sensory–sympathetic axis

Wei, H. K., Yu, C. D., Hu, B., Zeng, X., Ichise, H., Li, L., Wang, Y., Wang, R., Germain, R. N., Chang, R. B., et al. (2026) · Nature · doi:10.1038/s41586-025-10028-8 · Cited by 61 · see citing works

Norepinephrine inhibits CD8+ T-cell infiltration and function, inducing anti-PD-1 mAb resistance in lung adenocarcinoma

Geng, Q., Li, L., Shen, Z., Zheng, Y., Wang, L., Xue, R., Xue, W., Peng, M., & Zhao, J. (2023) · British Journal of Cancer · doi:10.1038/s41416-022-02132-7 · Cited by 53 · see citing works

The Use of Antihypertensive Drugs as Coadjuvant Therapy in Cancer

Carlos-Escalante, J. A., de Jesús-Sánchez, M., Rivas-Castro, A., Pichardo‐Rojas, P. S., Arce, C., & Wegman-Ostrosky, T. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.660943 · Cited by 52 · see citing works

LKB1 and Tumor Metabolism: The Interplay of Immune and Angiogenic Microenvironment in Lung Cancer

Bonanno, L., Zulato, E., Pavan, A., Attili, I., Pasello, G., Conte, P., & Indraccolo, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081874 · Cited by 52 · see citing works

What Characteristics of Urban Green Spaces and Recreational Activities Do Self-Reported Stressed Individuals Like? A Case Study of Baoji, China

Gao, T., Song, R., Zhu, L., & Qiu, L. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16081348 · Cited by 46 · see citing works

Coregulation of pathways in lung cancer patients with EGFR mutation: therapeutic opportunities

Rosell, R., Cardona, A. F., Arrieta, O. G., Aguilar, A., Ito, M., Pedraz‐Valdunciel, C., Codony‐Servat, J., & Santarpía, M. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01519-2 · Cited by 46 · see citing works

Propranolol for the treatment of vascular sarcomas

Wagner, M. J., Cranmer, L. D., Loggers, E. T., & Pollack, S. M. (2018) · Journal of Experimental Pharmacology · doi:10.2147/jep.s146211 · Cited by 43 · see citing works

Biological insights in non-small cell lung cancer

Rosell, R., Jain, A. S., Codony‐Servat, J., Lewintre, E. J., Morrison, B., Barretina, J. G., & González‐Cao, M. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0108 · Cited by 39 · see citing works

KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)

Rosell, R., Codony‐Servat, J., González, J., Santarpía, M., Jain, A. S., Shivamallu, C., Wang, Y., Giménez-Capitán, A. A., Molina‐Vila, M. Á., Nilsson, J. A., et al. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104228 · Cited by 39 · see citing works

A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma

Tan, X., Shi, L., Banerjee, P., Liu, X., Guo, H., Yu, J., Bota‐Rabassedas, N., Rodriguez, B. L., Gibbons, D. L., Russell, W. K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137186 · Cited by 39 · see citing works

Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop

Lin, X., Liu, H., Hsu, S.-J., Zhang, R., Chen, J., Chen, J., Gao, D., Cui, J., Ren, Z., & Chen, R. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01568-0 · Cited by 39 · see citing works

Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels

Jiang, S., Zhang, X.-X., Hu, L.-P., Wang, X., Li, Q., Zhang, X., Li, J., Gu, J., & Zhang, Z. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.586757 · Cited by 34 · see citing works

Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling

Li, L., Li, Z., Lu, C., Li, J., Zhang, K., Lin, C., Tang, X., Liu, Z., Zhang, Y., Han, R., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03111-7 · Cited by 34 · see citing works

Investigating the crosstalk between chronic stress and immune cells: implications for enhanced cancer therapy

Lei, Y., Liao, F., Tian, Y., Wang, Y., Xia, F., & Wang, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1321176 · Cited by 35 · see citing works

β2-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

Mele, L. L., Vecchio, V. D., Marampon, F., Regad, T., Wagner, S., Mosca, L., Bimonte, S., Giudice, A., Liccardo, D., Prisco, C., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03056-x · Cited by 33 · see citing works

Psychological intervention to treat distress: An emerging frontier in cancer prevention and therapy

Yang, M., Zhang, Z., Nice, E. C., Wang, C., Zhang, W., & Huang, C. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188665 · Cited by 33 · see citing works

Exposure–Response Analysis of Osimertinib in Patients with Advanced Non-Small-Cell Lung Cancer

Rodier, T., Puszkiel, A., Cardoso, E., Balakirouchenane, D., Narjoz, C., Arrondeau, J., Fallet, V., Khoudour, N., Guidi, M., Vidal, M., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091844 · Cited by 32 · see citing works

Tumor immune microenvironment in epidermal growth factor receptor-mutated non-small cell lung cancer before and after epidermal growth factor receptor tyrosine kinase inhibitor treatment: a narrative review

Liu, L., Wang, C., Li, S., Bai, H., & Wang, J. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-21-572 · Cited by 32 · see citing works

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Raimondi, F., Inoue, A., Kadji, F. M. N., Ni, S., González‐Sánchez, J. C., Singh, G., de la Vega, A. A., Sotillo, R., Fischer, B., Aoki, J., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0895-2 · Cited by 30 · see citing works

18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer

Mitchell, K. G., Amini, B., Wang, Y., Carter, B. W., Godoy, M. C. B., Parra, E. R., Behrens, C., Villalobos, P. A., Reuben, A., Lee, J. J., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02560-5 · Cited by 31 · see citing works

β2-Adrenergic Receptor Signaling Pathway Stimulates the Migration and Invasion of Cancer Cells via Src Activation

Jeong, J.-H., Park, H.-J., Park, S., Choi, Y. H., & Chi, G. (2022) · Molecules · doi:10.3390/molecules27185940 · Cited by 31 · see citing works

Cigarette smoke enhances oncogene addiction to c‐ MET and desensitizes EGFR ‐expressing non‐small cell lung cancer to EGFR TKI s

Tu, C., Cheng, F., Chen, C., Wang, S., Hsiao, Y., Chen, C., Hsia, T., He, Y., Wang, B., Hsieh, I., et al. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12193 · Cited by 29 · see citing works

The role of adrenergic receptors in lung cancer.

Huang, Q., Tan, Q., Mao, K., Yang, G., Ma, G., Luo, P., Wang, S., Mei, P., Wu, F., Xu, J., et al. (2018) · Europe PMC (PubMed Central) · Cited by 29 · see citing works

Neuroendocrine Regulation of Stress‐Induced T Cell Dysfunction during Lung Cancer Immunosurveillance via the Kisspeptin/GPR54 Signaling Pathway

Zhang, S., Yu, F., Che, A., Tan, B., Huang, C., Chen, Y., Liu, X., Huang, Q., Zhang, W., Ma, C., et al. (2022) · Advanced Science · doi:10.1002/advs.202104132 · Cited by 28 · see citing works

The β-Blocker Carvedilol Prevents Benzo(a)pyrene-Induced Lung Toxicity, Inflammation and Carcinogenesis

Shahid, A., Chen, M., Lin, C., Andresen, B. T., Parsa, C., Orlando, R., & Huang, Y. S. (2023) · Cancers · doi:10.3390/cancers15030583 · Cited by 26 · see citing works

Oxytocin involves in chronic stress-evoked melanoma metastasis via β-arrestin 2-mediated ERK signaling pathway

Ji, H., Liu, N., Li, J., Chen, D., Luo, D., Sun, Q., Liu, Y., Liu, Y., Bu, B., Chen, X., et al. (2019) · Carcinogenesis · doi:10.1093/carcin/bgz064 · Cited by 26 · see citing works

Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

Zhang, Z., Lv, Z. G., Lu, M., Li, H., & Zhou, J. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189121 · Cited by 26 · see citing works

Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression

Liu, C., Du, H., Yu, G., Qi, J., Dong, H., Hu, R., Wang, F., Cui, B., Chen, W., Zhang, Q., et al. (2025) · Cancer Research · doi:10.1158/0008-5472.can-24-3481 · Cited by 25 · see citing works

Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility

Hylander, B. L., Repasky, E. A., & Sexton, S. (2022) · Animals · doi:10.3390/ani12030371 · Cited by 28 · see citing works

Short-term exposure to ZnO/MCB persistent free radical particles causes mouse lung lesions via inflammatory reactions and apoptosis pathways

Zhang, X., Gu, W., Ma, Z., Liu, Y., Ru, H., Zhou, J., Zang, Y., Xu, Z. P., & Qian, G. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114039 · Cited by 25 · see citing works

The role of ADRB2 gene polymorphisms in malignancies

Wang, Y., & Jiang, S. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06250-y · Cited by 24 · see citing works

Chronic stress: a fourth etiology in tumorigenesis?

Khan, A., Song, M., & Dong, Z. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02402-x · Cited by 27 · see citing works

Effect of β-Blocker in Treatment-Naïve Patients With Advanced Lung Adenocarcinoma Receiving First-Generation EGFR-TKIs

Chang, C.-H., Lee, C., Ko, J., Chang, L., Lee, M., Zhang, J.-F., Wang, J., Shih, J., & Yu, C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.583529 · Cited by 24 · see citing works

Tumor microenvironment in osteosarcoma: From cellular mechanism to clinical therapy

Yu, Y., Li, K., Peng, Y., Zhang, Z., Pu, F., Shao, Z., & Wu, W. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101569 · Cited by 23 · see citing works

β2‐AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells

Liu, D., Zha, L., Liu, Y., Zhao, X., Xu, X., Liu, S., Ma, W., Zheng, J., & Shi, M. (2020) · Cancer Science · doi:10.1111/cas.14676 · Cited by 21 · see citing works

LMNA Reduced Acquired Resistance to Erlotinib in NSCLC by Reversing the Epithelial–Mesenchymal Transition via the FGFR/MAPK/c-fos Signaling Pathway

Hu, C., Zhou, A., Hu, X., Yu, X., Huang, M., Huang, J., Yang, D., & Tang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113237 · Cited by 21 · see citing works

Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability

Bu, C., Hu, S., Yu, J., Li, N., Gu, J., Sheng, Z., Yan, Z., & Bu, X. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-03032-1 · Cited by 20 · see citing works

LKB1/STK11 Expression in Lung Adenocarcinoma and Associations With Patterns of Recurrence

Mitchell, K. G., Parra, E. R., Zhang, J., Nelson, D. B., Corsini, E. M., Villalobos, P. A., Moran, C. A., Skoulidis, F., Wistuba, I. I., Fujimoto, J., et al. (2020) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2020.03.114 · Cited by 16 · see citing works

Monoamine Oxidase-B Inhibitor Reduction in Pro-Inflammatory Cytokines Mediated by Inhibition of cAMP-PKA/EPAC Signaling

Putnins, E. E., Goebeler, V., & Ostadkarampour, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.741460 · Cited by 17 · see citing works

Effect of beta-blockers on survival of lung cancer patients: a systematic review and meta-analysis

Coelho, M., Squizzato, A., Cassina, N., Marino, F., Ribeiro, L. V. P. T., & Cosentino, M. (2019) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000544 · Cited by 18 · see citing works

Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling

Wang, W., Xia, X., Chen, K., Meng, C., Meng, Y., Lv, D., & Yang, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.665045 · Cited by 18 · see citing works

AHSA1-HSP90AA1 complex stabilized IFI6 and TGFB1 promotes mitochondrial stability and EMT in EGFR-mutated lung adenocarcinoma under Osimertinib pressure

Sui, Y., Shen, Z., Pan, R., Ma, R., Si, R., Feng, J., & Zhou, G. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07650-9 · Cited by 17 · see citing works

Xiaoyaosan, a traditional Chinese medicine, inhibits the chronic restraint stress-induced liver metastasis of colon cancer in vivo

Zhao, L., Zhu, X., Ni, Y., You, J., & Li, A. (2020) · Pharmaceutical Biology · doi:10.1080/13880209.2020.1839513 · Cited by 18 · see citing works

A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment

Dragomir, M. P., Moisoiu, V., Manaila, R., Pardini, B., Knutsen, E., Anfossi, S., Amit, M., & Călin, G. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113529 · Cited by 17 · see citing works

Beta-Blocker Use and Lung Cancer Mortality in a Nationwide Cohort Study of Patients with Primary Non–Small Cell Lung Cancer

Udumyan, R., Montgomery, S., Fang, F., Valdimarsdóttir, U. A., Harðardóttir, H., Ekbom, A., Smedby, K. E. E., & Fall, K. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-19-0710 · Cited by 17 · see citing works

IFITM3-MET interaction drives osimertinib resistance through AKT pathway activation in EGFR-mutant non–small cell lung cancer

Ibusuki, R., Iwama, E., Shimauchi, A., Kawano, H., Mizusaki, S., Nakamura, S., Miyazaki, Y., Inutsuka, Y., Hashisako, M., Harada, T., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02493-6 · Cited by 16 · see citing works

Increased Sympathetic Nervous System Impairs Prognosis in Lung Cancer Patients: A Scoping Review of Clinical Studies

Garramona, F. T., Cunha, T. F., Vieira, J. S., Borges, G. S., Santos, G., de Castro, G., Ugrinowitsch, C., & Brum, P. C. (2023) · Lung Cancer Management · doi:10.2217/lmt-2023-0006 · Cited by 16 · see citing works

Neural regulation of drug resistance in cancer treatment

Liu, D., Li, X., Chen, X., Sun, Y. H., Tang, A., Li, Z., Zheng, J., & Shi, M. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.10.001 · Cited by 15 · see citing works

The sympathetic nervous system shapes the tumor microenvironment to impair chemotherapy response

Manoleras, A. V., Sloan, E. K., & Chang, A. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1460493 · Cited by 15 · see citing works

GPCRs in head and neck squamous cell carcinoma

Wu, V. H., & Gutkind, J. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817868-3.00015-9 · Cited by 13 · see citing works

Adrenergic microenvironment driven by cancer‐associated Schwann cells contributes to chemoresistance in patients with lung cancer

Otani, Y., Katayama, H., Zhu, Y., Huang, R., Shigehira, T., Shien, K., Suzawa, K., Yamamoto, H., Shien, T., Toyooka, S., et al. (2024) · Cancer Science · doi:10.1111/cas.16164 · Cited by 13 · see citing works

ß-Adrenoreceptors in Human Cancers

Krabóth, Z., & Kálmán, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043671 · Cited by 14 · see citing works

β2-AR inhibition enhances EGFR antibody efficacy hampering the oxidative stress response machinery

Vecchio, V. D., Mele, L. L., Panda, S. K., Sanchez-Pajares, I. R., Mosca, L., Tirino, V., Barbieri, M., Bruzzese, F., Luciano, A., Marino, F. Z., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06129-9 · Cited by 12 · see citing works

Comprehensive analysis of microRNA‐messenger RNA regulatory network in gemcitabine‐resistant bladder cancer cells

Zhang, S., Chang, Y., Gong, Y., Gao, Y., Guo, Q., Wang, Y., Zhao, Y., & Wang, Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27922 · Cited by 12 · see citing works

Stress-related hormone reduces autophagy through the regulation of phosphatidylethanolamine in breast cancer cells

Zhu, Z., Yu, R., Yang, C., Li, D., Wang, J., Yang, W., Ji, Y., Wang, L., Wang, Y., & Jiang, F. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-8176 · Cited by 12 · see citing works

Mechanisms underlying the effects of stress on tumorigenesis and metastasis (Review)

Zhang, Z., Wang, Y., & Li, Q. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4570 · Cited by 13 · see citing works

Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology

Coelho, M., Imperatori, A. S., Chiaravalli, A. M., Franzi, F., Castiglioni, M., Rasini, E., Luini, A., Legnaro, M., Marino, F., Ribeiro, L. V. P. T., et al. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09879-6 · Cited by 11 · see citing works

Fear stress enhanced xenograft pancreatic tumor growth through activating epithelial-mesenchymal transition

Li, M., & Xu, H. (2019) · Pancreatology · doi:10.1016/j.pan.2019.01.002 · Cited by 12 · see citing works

Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells

Botello, J. F., Corral, P. A., Bian, T., & Xing, C. (2019) · Planta Medica · doi:10.1055/a-1035-5183 · Cited by 11 · see citing works

Sympathetic β2-adrenergic receptor blockade overcomes docetaxel resistance in prostate cancer

Zhang, M., Chen, F., Sun, X., Huang, Y., Zeng, Y., Chen, J., Wu, S., & Chen, X. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.046 · Cited by 10 · see citing works

Beta-Adrenergic Blockade in Advanced Non-Small Cell Lung Cancer Patients Receiving Immunotherapy: A Multicentric Study

Mendes, A. D., Freitas, A. R., Vicente, R. S., Ferreira, R., Martins, T., Ramos, M. J., Baptista, C., Silva, B. M., Margarido, I., Vitorino, M. M., et al. (2024) · Cureus · doi:10.7759/cureus.52194 · Cited by 10 · see citing works

Opportunities and challenges of co‑targeting epidermal growth factor receptor and autophagy signaling in non‑small cell lung cancer (Review)

Wang, X., Li, W., Zhang, N., Zheng, X., & Zhao, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10372 · Cited by 10 · see citing works

Cx32 mediates norepinephrine‐promoted EGFR‐TKI resistance in a gap junction‐independent manner in non‐small‐cell lung cancer

Xie, J., Wang, X., Ge, H., Peng, F., Zheng, N., Wang, Q., & Tao, L. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28881 · Cited by 10 · see citing works

Renin-angiotensin inhibitors were associated with improving outcomes of hepatocellular carcinoma with primary hypertension after hepatectomy

Feng, L.-H., Sun, H., Zhu, X., Zhang, S.-Z., Li, K., Li, X., Li, Y., & Tang, Z. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.11.131 · Cited by 10 · see citing works

Impact of Tumoral β2-Adrenergic Receptor Expression on Chemotherapeutic Response and Prognosis in Patients with Advanced Colorectal Cancer

Komine, C., Sohda, M., Yokobori, T., Shioi, I., Ozawa, N., Shibasaki, Y., Nakazawa, N., Osone, K., Shiraishi, T., Okada, T., et al. (2024) · Annals of Surgical Oncology · doi:10.1245/s10434-024-16195-8 · Cited by 9 · see citing works

Chromosomal Instability Is Associated with cGAS–STING Activation in EGFR-TKI Refractory Non-Small-Cell Lung Cancer

Yonesaka, K., Kurosaki, T., Tanizaki, J., Kawakami, H., Tanaka, K., Maenishi, O., Takamura, S., Sakai, K., Chiba, Y., Teramura, T., et al. (2025) · Cells · doi:10.3390/cells14060447 · Cited by 9 · see citing works

Cancer and neurotransmitter receptors

Wang, X., Shi, M., Tian, J., & Yu, W. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003656 · Cited by 10 · see citing works

The crosstalk between nerves and immunity: chronic stress as a driver of tumor progression

He, Y., Yu, H., Li, F., Liu, J., Chen, Z., Zhu, W., Yang, L., & Yan, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1758894 · Cited by 12 · see citing works

The Effects of Artificial Lake Space on Satisfaction and Restorativeness of the Overall Environment and Soundscape in Urban Parks

Qi, Y., Fang, X., Gao, T., & Qiu, L. (2021) · Frontiers in Built Environment · doi:10.3389/fbuil.2021.664442 · Cited by 10 · see citing works

Suppression of the innate cancer-killing activity in human granulocytes by stress reaction as a possible mechanism for affecting cancer development

Huang, X., Le, W., Chen, Q., Chen, J., Zhu, Y., Shi, D., Chen, B., & Cui, Z. (2019) · Stress · doi:10.1080/10253890.2019.1645112 · Cited by 8 · see citing works

Comprehensive network analysis of dysregulated genes revealed MNX1‐AS1 / hsa‐miR ‐4697‐3p/ HOXB13 axis in ovarian cancer chemotherapy response

Wu, A., Liu, J., Zhang, X., Niu, C., Shu, G., & Yin, G. (2022) · Cancer Science · doi:10.1111/cas.15447 · Cited by 8 · see citing works

The Nervous System as a Regulator of Cancer Hallmarks: Insights into Therapeutic Implications

Torres-Juárez, K. V., QUEIROGA, F. L., & Romero-Romero, L. P. (2022) · Cancers · doi:10.3390/cancers14184372 · Cited by 9 · see citing works

G Protein-coupled and Membrane Tyrosine Kinase Receptor Relationships Yield Therapeutic Opportunities

Girnita, L., Janssen, J. A. M. J. L., & Smith, T. J. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf019 · Cited by 7 · see citing works

A pomalidomide-based gefitinib PROTAC degrader effectively inhibits lung cancer progression in EGFR-TKIs-acquired resistant models by targeting EGFR degradation and ETFA-mediated ATP generation

Li, L., Li, Y., Ma, X., Li, P., Zeng, S., Jiang, F., & Zhang, G. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108864 · Cited by 7 · see citing works

The Activity of EGFR CAR NK and CAR T Cells against EGFR Inhibitor–Resistant NSCLC and Drug-Tolerant Persister Cells

Yang, Y., Nilsson, M. B., Yu, X., Poteete, A., Jiang, H., Huang, Q., He, J., Heeke, S., & Heymach, J. V. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-1693 · Cited by 7 · see citing works

Rational Combinations of PARP Inhibitors with HRD-Inducing Molecularly Targeted Agents

Lee, E. K., & Liu, J. F. (2023) · Cancer treatment and research · doi:10.1007/978-3-031-30065-3_10 · Cited by 6 · see citing works

Association Between Digoxin Use and Cancer Incidence: A Propensity Score-Matched Cohort Study With Competing Risk Analysis

Tai, C.-J., Yang, Y., Tseng, T., Chang, F., & Wang, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.564097 · Cited by 6 · see citing works

Abstract 4662: Beta blockers abrogate EGFR TKI resistance induced by adrenergic receptor-mediated upregulation of IL-6 and modulation of the LKB1/AMPK/mTOR axis

Nilsson, M. B., Sun, H., Diao, L., Tong, P., Fan, Y.-H., Tran, H. T., Liu, D., Armaiz-Peña, G. N., Wang, J., Rowe, P. J., et al. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-4662

Chronic Stress Hormones May Promote Resistance to EGFR Inhibitors

(2017) · Oncology Times · doi:10.1097/01.cot.0000527904.90180.2e

The impact of ß-blockers in non–small cell lung cancer patients treated with Epidermal Growth Factor Receptor Kinase Inhibitors, Taiwan NHIRD database study.

Fan, G. W., & Lin, C. (2018) · Lung Cancer · doi:10.1183/13993003.congress-2018.pa2855

Blocking beta adrenergic signaling may be a target for overcoming EGFR TKI resistance.

Heo, E. Y., Lee, M., Lee, J., Kim, D. K., & Chung, H. S. (2018) · Lung Cancer · doi:10.1183/13993003.congress-2018.pa2854

2060eP Prognostic impact of concomitant beta-blocker use on survival in EGFR-mutant metastatic non-small cell lung cancer patients treated with erlotinib

Yıldız, O., Aykut, T., Kaya, B. E., Genç, Ö., Gürbüz, A. F., Eryılmaz, M. K., Araz, M., & Artaç, M. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.08.2681