Kreutz, Clemens

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

Raue, A., Kreutz, C., Maiwald, T., Bachmann, J., Schilling, M., Klingmüller, U., & Timmer, J. (2009) · Bioinformatics

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 1,442

Systems biology: experimental design

Kreutz, C., & Timmer, J. (2009) · The FEBS Journal

Optimal Experimental Design MethodsGene Regulatory Network Analysis

Cited by 257

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

Goldmann, T., Zeller, N., Raasch, J., Kierdorf, K., Frenzel, K., Ketscher, L., Basters, A., Staszewski, O., Brendecke, S. M., Spiess, A., et al. (2015) · The EMBO Journal

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 223

Data-based identifiability analysis of non-linear dynamical models

Hengl, S., Kreutz, C., Timmer, J., & Maiwald, T. (2007) · Bioinformatics

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 166

Addressing parameter identifiability by model-based experimentation

Raue, A., Kreutz, C., Maiwald, T., Klingmüller, U., & Timmer, J. (2011) · IET Systems Biology

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 145

Likelihood based observability analysis and confidence intervals for predictions of dynamic models

Kreutz, C., Raue, A., & Timmer, J. (2012) · BMC Systems Biology

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 134

Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways

Klingmüller, U., Bauer, A., Bohl, S., Nickel, P. J., Breitkopf, K., Dooley, S., Zellmer, S., Kern, C., Merfort, I., Sparna, T., et al. (2006) · IEE Proceedings - Systems Biology

Liver physiology and pathologyGene Regulatory Network Analysis

Cited by 127

An error model for protein quantification

Kreutz, C., Rodriguez, M. M. B., Maiwald, T., Seidl, M., Blum, H. E., Mohr, L., & Timmer, J. (2007) · Bioinformatics

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 107

PEtab—Interoperable specification of parameter estimation problems in systems biology

Schmiester, L., Schälte, Y., Bergmann, F. T., Camba, T., Dudkin, E., Egert, J., Fröhlich, F., Fuhrmann, L., Hauber, A. L., Kemmer, S., et al. (2021) · PLOS Computational Biology

Gene Regulatory Network AnalysisScientific Computing and Data Management

Cited by 96

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

Schilling, M., Maiwald, T., Hengl, S., Winter, D., Kreutz, C., Kolch, W., Lehmann, W. D., Timmer, J., & Klingmüller, U. (2009) · Molecular Systems Biology

Gene Regulatory Network AnalysisProtein Kinase Regulation and GTPase Signaling

Cited by 79

Cause and cure of sloppiness in ordinary differential equation models

Tönsing, C., Timmer, J., & Kreutz, C. (2014) · Physical Review E

Gene Regulatory Network AnalysisControl Systems and Identification

Cited by 33

Characterizing the omics landscape based on 10,000+ datasets

Brombacher, E., Schilling, O., & Kreutz, C. (2024) · Scientific Reports

Bioinformatics and Genomic NetworksGene expression and cancer classification

Cited by 6