Costa, Kevin D.

Laminar fiber architecture and three-dimensional systolic mechanics in canine ventricular myocardium

Costa, K. D., Takayama, Y., McCulloch, A. D., & Covell, J. W. (1999) · American Journal of Physiology-Heart and Circulatory Physiology

Cardiovascular Function and Risk FactorsElasticity and Material Modeling

Cited by 313

Advancing functional engineered cardiac tissues toward a preclinical model of human myocardium

Turnbull, I. C., Karakikes, I., Serrao, G. W., Backeris, P., Lee, J., Xie, C., Senyei, G., Gordon, R. E., Li, R. A., Akar, F. G., et al. (2014) · The FASEB Journal

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

Cited by 184

Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells

Li, R. A., Keung, W., Cashman, T. J., Backeris, P. C., Johnson, B. V., Bardot, E. S., Wong, A. O. T., Chan, P. K. W., Chan, C. W. Y., & Costa, K. D. (2018) · Biomaterials

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 175

Relating myocardial laminar architecture to shear strain and muscle fiber orientation

Arts, T., Costa, K. D., Covell, J. W., & McCulloch, A. D. (2001) · American Journal of Physiology-Heart and Circulatory Physiology

Cardiovascular Function and Risk FactorsElasticity and Material Modeling

Cited by 172

Microscale frictional response of bovine articular cartilage from atomic force microscopy

Park, S., Costa, K. D., & Ateshian, G. A. (2004) · Journal of Biomechanics

Force Microscopy Techniques and ApplicationsOsteoarthritis Treatment and Mechanisms

Cited by 139

Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytes

Zhu, R., Blazeski, A., Poon, E., Costa, K. D., Tung, L., & Boheler, K. R. (2014) · Stem Cell Research & Therapy

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 110

Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy

Cashman, T. J., Josowitz, R., Johnson, B. V., Gelb, B. D., & Costa, K. D. (2016) · PLOS ONE

Pluripotent Stem Cells ResearchCardiomyopathy and Myosin Studies

Cited by 101

Direct hydrogel encapsulation of pluripotent stem cells enables ontomimetic differentiation and growth of engineered human heart tissues

Kerscher, P., Turnbull, I. C., Hodge, A. J., Kim, J., Seliktar, D., Easley, C. J., Costa, K. D., & Lipke, E. A. (2016) · Biomaterials

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 88

Engineered cardiac organoid chambers: toward a functional biological model ventricle

Lee, E. J., Kim, D. E., Azeloglu, E. U., & Costa, K. D. (2008) · Tissue Engineering Part A

Tissue Engineering and Regenerative Medicine3D Printing in Biomedical Research

Cited by 84

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Stillitano, F., Turnbull, I. C., Karakikes, I., Nonnenmacher, M., Backeris, P., Hulot, J.-S., Kranias, E. G., Hajjar, R. J., & Costa, K. D. (2016) · European Heart Journal

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 77

Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias

Wang, J., Chen, A., Lieu, D. K., Karakikes, I., Chen, G., Keung, W., Chan, C. W., Hajjar, R. J., Costa, K. D., Khine, M., et al. (2013) · Biomaterials

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

Cited by 69

Human cardiac ventricular-like organoid chambers and tissue strips from pluripotent stem cells as a two-tiered assay for inotropic responses

Keung, W., Chan, P. K. W., Backeris, P. C., Lee, E. K., Wong, N., Wong, A. O. T., Wong, G. K. Y., Chan, C. W. Y., Fermini, B., Costa, K. D., et al. (2019) · Clinical Pharmacology & Therapeutics

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 54

Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs

Chen, G., Li, S., Karakikes, I., Ren, L., Zi-Ying Chow, M., Chopra, A., Keung, W., Yan, B., Chan, C. W. Y., Costa, K. D., et al. (2015) · Circulation: Arrhythmia and Electrophysiology

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 38

A micropatterned human pluripotent stem cell-based ventricular cardiac anisotropic sheet for visualizing drug-induced arrhythmogenicity

Shum, A. M. Y., Che, H., Wong, A. O., Zhang, C., Wu, H., Chan, C. W. Y., Costa, K., Khine, M., Kong, C., & Li, R. A. (2017) · Advanced Materials

Cardiac electrophysiology and arrhythmiasTissue Engineering and Regenerative Medicine

Cited by 37

Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells

Wong, A. O.-T., Wong, G., Shen, M., Chow, M. Z.-Y., Tse, W. W., Gurung, B., Mak, S. Y., Lieu, D. K., Costa, K. D., Chan, C. W., et al. (2019) · Stem Cell Research & Therapy

Pluripotent Stem Cells ResearchCardiac electrophysiology and arrhythmias

Cited by 27

Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies

Turnbull, I. C., Mayourian, J., Murphy, J. F., Stillitano, F., Ceholski, D. K., & Costa, K. D. (2018) · Methods in molecular biology

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 26

Single-cell RNA sequencing reveals maturation trajectory in human pluripotent stem cell-derived cardiomyocytes in engineered tissues

Cheng, S., Brenière-Letuffe, D., Ahola, V., Wong, A. O. T., Keung, H. Y., Gurung, B., Zheng, Z., Costa, K. D., Lieu, D. K., Keung, W., et al. (2023) · iScience

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 23

Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues

Wong, A. O.-T., Gurung, B., Wong, W. S., Mak, S. Y., Tse, W. W., Li, C. M., Lieu, D. K., Costa, K. D., Li, R. A., & Hajjar, R. J. (2021) · Journal of Molecular and Cellular Cardiology

Cardiac electrophysiology and arrhythmiasPluripotent Stem Cells Research

Cited by 16

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Cashman, T. J., Josowitz, R., Gelb, B. D., Li, R. A., Dubois, N. C., & Costa, K. D. (2016) · Journal of Visualized Experiments

Tissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

Cited by 7

Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial

Costa, K. D., Wong, A. O. T., Mak, S. Y., Roberts, E. G., Keung, W., Correia, C., Walentinsson, A., Christoffersson, J., Cheung, A., Lieu, D. K., et al. (2024) · bioRxiv

Cardiac electrophysiology and arrhythmiasCardiovascular Function and Risk Factors

Cited by 5