Kell, Douglas B.

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry.

The Human Serum Metabolome (HUSERMET) Consortium, Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., Brown, M., Knowles, J. D., Halsall, A., et al. (2011) · Nature Protocols

Metabolomics and Mass Spectrometry StudiesAdvanced Proteomics Techniques and Applications

Cited by 3,294

Oscillations in NF-κB Signaling Control the Dynamics of Gene Expression

Nelson, D. E., Ihekwaba, A. E. C., Elliott, M., Johnson, J. R., Gibney, C. A., Foreman, B. E., Nelson, G., See, V., Horton, C. A., Spiller, D. G., et al. (2004) · Science

NF-κB Signaling PathwaysGene Regulatory Network Analysis

Cited by 1,186

A community-driven global reconstruction of human metabolism

Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., Haraldsdottir, H., Mo, M. L., Rolfsson, O., Stobbe, M. D., et al. (2013) · Nature Biotechnology

Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks

Cited by 1,019

The systems biology graphical notation.

Novère, N. L., Hucka, M., Mi, H., Moodie, S., Schreiber, F., Sorokin, A., Demir, E., Wegner, K., Aladjem, M. I., Wimalaratne, S. M., et al. (2009) · Nature Biotechnology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 903

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

Kell, D. B., & Pretorius, E. (2014) · Metallomics

Iron Metabolism and DisordersTrace Elements in Health

Cited by 667

Functional genomic hypothesis generation and experimentation by a robot scientist

King, R. D., Whelan, K. E., Jones, F. M., Reiser, P. G. K., Bryant, C. H., Muggleton, S. H., Kell, D. B., & Oliver, S. G. (2004) · Nature

Scientific Computing and Data ManagementBioinformatics and Genomic Networks

Cited by 662

What do we need to build explainable AI systems for the medical domain?

Holzinger, A., Biemann, C., Pattichis, C. S., & Kell, D. B. (2017) · arXiv

Explainable Artificial Intelligence (XAI)Artificial Intelligence in Healthcare and Education

Cited by 636

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology

Herrgård, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., Blüthgen, N., Borger, S., Costenoble, R., Heinemann, M., et al. (2008) · Nature Biotechnology

Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks

Cited by 588

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics

Iron Metabolism and DisordersAntioxidant Activity and Oxidative Stress

Cited by 554

Pulsatile Stimulation Determines Timing and Specificity of NF-κB-Dependent Transcription

Ashall, L., Horton, C. A., Nelson, D. E., Paszek, P., Harper, C. V., Sillitoe, K., Ryan, S., Spiller, D. G., Unitt, J. F., Broomhead, D. S., et al. (2009) · Science

NF-κB Signaling PathwaysGene Regulatory Network Analysis

Cited by 543

Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis‐driven science in the post‐genomic era

Kell, D. B., & Oliver, S. G. (2004) · BioEssays

Philosophy of Biology and Scientific ExplanationScientific Computing and Data Management

Cited by 535

Microbes and Alzheimer’s Disease

Itzhaki, R. F., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., Bullido, M. J., Carter, C., Clerici, M., Cosby, S. L., et al. (2016) · Journal of Alzheimer’s Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 532

Metabolomics and systems biology: making sense of the soup

KELL, D. (2004) · Current Opinion in Microbiology

Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks

Cited by 529

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

Dobson, P. D., & Kell, D. B. (2008) · Nature Reviews Drug Discovery

Drug Transport and Resistance MechanismsDrug Solubulity and Delivery Systems

Cited by 475

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

Kell, D. B., Heyden, E. L., & Pretorius, E. (2020) · Frontiers in Immunology

Antimicrobial Peptides and ActivitiesInfant Nutrition and Health

Cited by 460

Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration

Kell, D. B. (2011) · Annals of Botany

Soil Carbon and Nitrogen DynamicsSoil Management and Crop Yield

Cited by 439

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology

Iron Metabolism and DisordersCell death mechanisms and regulation

Cited by 361

Controlled vocabularies and semantics in systems biology

Courtot, M., Juty, N., Knüpfer, C., Waltemath, D., Zhukova, A., Dräger, A., Dumontier, M., Finney, A., Golebiewski, M., Hastings, J., et al. (2011) · Molecular Systems Biology

Biomedical Text Mining and OntologiesGene Regulatory Network Analysis

Cited by 316

The role of lipopolysaccharide-induced cell signalling in chronic inflammation

Page, M. J., Kell, D. B., & Pretorius, E. (2022) · Chronic Stress

Immune Response and InflammationSepsis Diagnosis and Treatment

Cited by 315

Multiobjective Optimization in Bioinformatics and Computational Biology

Handl, J., Kell, D. B., & Knowles, J. (2007) · IEEE/ACM Transactions on Computational Biology and Bioinformatics

Advanced Multi-Objective Optimization AlgorithmsGenomics and Phylogenetic Studies

Cited by 308

The biology of ergothioneine, an antioxidant nutraceutical

Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, S. A., & Kell, D. B. (2020) · Nutrition Research Reviews

Sulfur Compounds in BiologyAntioxidant Activity and Oxidative Stress

Cited by 296

Recon 2.2: from reconstruction to model of human metabolism

Swainston, N., Smallbone, K., Hefzi, H., Dobson, P. D., Brewer, J., Hanscho, M., Zielinski, D. C., Ang, K. S., Gardiner, N. J., Gutierrez, J. M., et al. (2016) · Metabolomics

Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic Networks

Cited by 285

Growth control of the eukaryote cell: a systems biology study in yeast

Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., et al. (2007) · Journal of Biology

Fungal and yeast genetics researchMicrobial Metabolic Engineering and Bioproduction

Cited by 263

The rpf gene of Micrococcus luteus encodes an essential secreted growth factor

Mukamolova, G. V., Turapov, O. A., Kazarian, K., Telkov, M., Kaprelyants, A. S., Kell, D. B., & Young, M. (2002) · Molecular Microbiology

Bacterial Genetics and BiotechnologyTuberculosis Research and Epidemiology

Cited by 178