Hageman, Gregory S.

A common haplotype in the complement regulatory gene factor H ( HF1/CFH ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 1,961

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

Hageman, G. (2001) · Progress in Retinal and Eye Research

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

Cited by 1,265

A role for local inflammation in the formation of drusen in the aging eye

Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

Cited by 1,087

Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

The AMD Genetics Clinical Study Group, Gold, B., Merriam, J. E., Zernant, J., Hancox, L. S., Taiber, A. J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., et al. (2006) · Nature Genetics

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 1,075

Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

Mullins, R. F., Russell, S. R., Anderson, D. H., & Hageman, G. S. (2000) · The FASEB Journal

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 937

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

Anderson, D. H., Radeke, M. J., Gallo, N. B., Chapin, E. A., Johnson, P. T., Curletti, C. R., Hancox, L. S., Hu, J., Ebright, J. N., Malek, G., et al. (2010) · Progress in Retinal and Eye Research

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 727

Characterization of β amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

Anderson, D. H., Talaga, K. C., Rivest, A. J., Barron, E., Hageman, G. S., & Johnson, L. V. (2004) · Experimental Eye Research

Retinal Diseases and TreatmentsAlzheimer's disease research and treatments

Cited by 319

Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

Anderson, D. H., Ozaki, S., Nealon, M., Neitz, J., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2001) · American Journal of Ophthalmology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 255

Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein

Laine, M., Jarva, H., Seitsonen, S., Haapasalo, K., Lehtinen, M. J., Lindeman, N., Anderson, D. H., Johnson, P. T., Järvelä, I., Jokiranta, T. S., et al. (2007) · The Journal of Immunology

Complement system in diseasesRetinal Diseases and Treatments

Cited by 246

Structure and composition of drusen associated with glomerulonephritis: Implications for the role of complement activation in drusen biogenesis

Mullins, R. F., Aptsiauri, N., & Hageman, G. S. (2001) · Eye

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

Cited by 231

Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid

Johnson, P. T., Betts, K. E., Radeke, M. J., Hageman, G. S., Anderson, D. H., & Johnson, L. V. (2006) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 223

Decreased Thickness and Integrity of the Macular Elastic Layer of Bruch's Membrane Correspond to the Distribution of Lesions Associated with Age-Related Macular Degeneration

Chong, N. H. V., Keonin, J., Luthert, P. J., Frennesson, C. I., Weingeist, D. M., Wolf, R. L., Mullins, R. F., & Hageman, G. S. (2005) · The American Journal of Pathology

Retinal Diseases and TreatmentsRetinal Imaging and Analysis

Cited by 218

Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells

Hageman, G. S., Mullins, R. F., Russell, S. R., Johnson, L. V., & Anderson, D. H. (1999) · The FASEB Journal

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 206

Delay to Treatment and Visual Outcomes in Patients Treated With Anti-Vascular Endothelial Growth Factor for Age-Related Macular Degeneration

Lim, J. H., Wickremasinghe, S. S., Xie, J., Chauhan, D. S., Baird, P. N., Robman, L. D., Hageman, G., & Guymer, R. H. (2012) · American Journal of Ophthalmology

Retinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

Cited by 141

TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye

Ryskamp, D. A., Frye, A. M., Phuong, T. T. T., Yarishkin, O., Jo, A. O., Xu, Y., Lakk, M., Iuso, A., Redmon, S. N., Ambati, B., et al. (2016) · Scientific Reports

Glaucoma and retinal disordersIon Channels and Receptors

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