Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

Anderson, Don H; Ozaki, Shiro; Nealon, Matthew; Neitz, Jay; Mullins, Robert F; Hageman, Gregory S; Johnson, Lincoln V

doi:10.1016/s0002-9394(00)00961-2

Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation

Purpose The inheritance of specific apolipoprotein E allelles has been linked to atherosclerosis, Alzheimer disease, and, most recently, to the incidence of age-related macular degeneration. Apolipoprotein E is a common component of the extracellular plaques and deposits characteristic of these d…