Clarke, Michael F.

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature

Cancer Cells and MetastasisDevelopmental Biology and Gene Regulation

Cited by 9,738

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature

Cancer Cells and MetastasisRedox biology and oxidative stress

Cited by 2,555

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 1,871

Single-cell transcriptional diversity is a hallmark of developmental potential

Gulati, G. S., Sikandar, S. S., Wesche, D. J., Manjunath, A., Bharadwaj, A., Berger, M. J., Ilagan, F., Kuo, A. H., Hsieh, R. W., Cai, S., et al. (2020) · Science

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 1,571

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium, Almanzar, N., Antony, J., Baghel, A. S., Bakerman, I., Bansal, I., Barres, B. A., Beachy, P. A., Berdnik, D., Bilen, B., et al. (2020) · Nature

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,247

The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

The Tabula Sapiens Consortium*, Jones, R. C., Karkanias, J., Krasnow, M. A., Pisco, A. O., Quake, S. R., Salzman, J., Yosef, N., Bulthaup, B., Brown, P., et al. (2022) · Science

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 1,056

Quantitative assessment of single-cell RNA-sequencing methods

Wu, A. R., Neff, N. F., Kalisky, T., Dalerba, P., Treutlein, B., Rothenberg, M. E., Mburu, F. M., Mantalas, G. L., Sim, S., Clarke, M. F., et al. (2014) · Nature Methods

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 696

Ageing hallmarks exhibit organ-specific temporal signatures

Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 671

Bmi1, stem cells, and senescence regulation

Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell Transplantation

Cited by 495

Clinical and Therapeutic Implications of Cancer Stem Cells

Clarke, M. F. (2019) · New England Journal of Medicine

Cancer Cells and MetastasisMesenchymal stem cell research

Cited by 355

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

Majeti, R., Becker, M. W., Tian, Q., Lee, T.-L. M., Yan, X., Liu, R., Chiang, J.-H., Hood, L., Clarke, M. F., & Weissman, I. L. (2009) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 281

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice

Rothenberg, M. E., Nusse, Y., Kalisky, T., Lee, J. J., Dalerba, P., Scheeren, F., Lobo, N., Kulkarni, S., Sim, S., Qian, D., et al. (2012) · Gastroenterology

Cancer Cells and MetastasisDigestive system and related health

Cited by 263

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 153

Cell types of origin of the cell-free transcriptome

Vorperian, S. K., Moufarrej, M. N., Tabula Sapiens Consortium, Overall Project Direction and Coordination, Jones, R. C., Karkanias, J., Krasnow, M., Pisco, A. O., Quake, S. R., Salzman, J., et al. (2022) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 116

Inhibiting USP16 rescues stem cell aging and memory in an Alzheimer’s model

Reinitz, F., Chen, E. Y., Nicolis di Robilant, B., Chuluun, B., Antony, J., Jones, R. C., Gubbi, N., Lee, K., Ho, W. H. D., Kolluru, S. S., et al. (2022) · eLife

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 18

CDK19 is a Regulator of Triple-Negative Breast Cancer Growth

Hsieh, R. W., Kuo, A. H., Scheeren, F. A., Zarnegar, M. A., Sikandar, S. S., Antony, J., Heitink, L. S., Periyakoil, D., Kalisky, T., Sim, S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

Breast Cancer Treatment StudiesCancer Cells and Metastasis

Cited by 3