Irvine, Alan D.

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 2,978

Atopic dermatitis

Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 1,549

Filaggrin Mutations Associated with Skin and Allergic Diseases

Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine

Dermatology and Skin DiseasesSkin and Cellular Biology Research

Cited by 1,217

Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials

Guttman-Yassky, E., Teixeira, H. D., Simpson, E. L., Papp, K. A., Pangan, A. L., Blauvelt, A., Thaçi, D., Chu, C.-Y., Hong, H. C.-H., Katoh, N., et al. (2021) · The Lancet

Dermatology and Skin DiseasesAsthma and respiratory diseases

Cited by 583

The microbiome in patients with atopic dermatitis

Paller, A. S., Kong, H. H., Seed, P., Naik, S., Scharschmidt, T. C., Gallo, R. L., Luger, T., & Irvine, A. D. (2019) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 525

The atopic march and atopic multimorbidity: many trajectories, many pathways

Paller, A. S., Spergel, J. M., Mina-Osorio, P., & Irvine, A. D. (2019) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesAsthma and respiratory diseases

Cited by 464

Filaggrin in atopic dermatitis

O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2008) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 350

Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity

Kezic, S., O’Regan, G. M., Yau, N., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Irwin McLean, W. H., et al. (2011) · Allergy

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 295

RETRACTED: Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year

Kelleher, M., Dunn-Galvin, A., Hourihane, J. O., Murray, D., Campbell, L. E., McLean, W. H. I., & Irvine, A. D. (2015) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 225

Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes

Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Fölster-Holst, R., Rodríguez, E., Lee, Y. A. E., Franke, A., Degenhardt, F., Lieb, W., et al. (2016) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesRheumatoid Arthritis Research and Therapies

Cited by 215

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., et al. (2015) · The American Journal of Human Genetics

Dermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 193

The exposome in atopic dermatitis

Stefanovic, N., Flohr, C., & Irvine, A. D. (2020) · Allergy

Dermatology and Skin DiseasesHealth, Environment, Cognitive Aging

Cited by 181

RETRACTED: Skin barrier impairment at birth predicts food allergy at 2 years of age

Kelleher, M. M., Dunn-Galvin, A., Gray, C., Murray, D. M., Kiely, M., Kenny, L., McLean, W. H. I., Irvine, A. D., & Hourihane, J. O. (2016) · Journal of Allergy and Clinical Immunology

Food Allergy and Anaphylaxis ResearchEosinophilic Esophagitis

Cited by 169

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

Saunders, S. P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., Quinn, E. M., Oliphant, C. J., Núñez, G., McManus, R., et al. (2016) · Journal of Allergy and Clinical Immunology

Dermatology and Skin DiseasesAsthma and respiratory diseases

Cited by 160

Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: Analysis of microbial diversity in ECZTRA 1, a randomized controlled trial

Beck, L. A., Bieber, T., Weidinger, S., Tauber, M., Saeki, H., Irvine, A. D., Eichenfield, L. F., Werfel, T., Arlert, P., Jiang, L., et al. (2023) · Journal of the American Academy of Dermatology

Dermatology and Skin DiseasesContact Dermatitis and Allergies

Cited by 56

Impact of climate change on atopic dermatitis: A review by the International Eczema Council

Wang, S., Stefanovic, N., Orfali, R. L., Aoki, V., Brown, S. J., Dhar, S., Eichenfield, L. F., Flohr, C., Ha, A., Mora, C., et al. (2024) · Allergy

Climate Change and Health ImpactsDermatology and Skin Diseases

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