Pinello, Luca

Eleven grand challenges in single-cell data science

Lähnemann, D., Köster, J., Szczurek, E., McCarthy, D. J., Hicks, S. C., Robinson, M. D., Vallejos, C. A., Campbell, K. R., Beerenwinkel, N., Mahfouz, A., et al. (2020) · Genome Biology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,327

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 886

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 653

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Wu, Y., Zeng, J., Roscoe, B. P., Liu, P., Yao, Q., Lazzarotto, C. R., Clement, K., Cole, M. A., Luk, K., Baricordi, C., et al. (2019) · Nature Medicine

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 515

Assessment of computational methods for the analysis of single-cell ATAC-seq data

Chen, H., Lareau, C., Andreani, T., Vinyard, M. E., Garcia, S. P., Clement, K., Andrade-Navarro, M. A., Buenrostro, J. D., & Pinello, L. (2019) · Genome Biology

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 332

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

Petri, K., Zhang, W., Ma, J., Schmidts, A., Lee, H., Horng, J. E., Kim, D. Y., Kurt, I. C., Clement, K., Hsu, J. Y., et al. (2022) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 208

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

Li, C. M.-C., Shapiro, H., Tsiobikas, C., Selfors, L. M., Chen, H., Rosenbluth, J., Moore, K., Gupta, K. P., Gray, G. K., Oren, Y., et al. (2020) · Cell Reports

Single-cell and spatial transcriptomicsBreast Cancer Treatment Studies

Cited by 184

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

Jadhav, U., Nalapareddy, K., Saxena, M., O’Neill, N. K., Pinello, L., Yuan, G.-C., Orkin, S. H., & Shivdasani, R. A. (2016) · Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 139

Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Reshef, Y. A., Finucane, H. K., Kelley, D. R., Gusev, A., Kotliar, D., Ulirsch, J. C., Hormozdiari, F., Nasser, J., O’Connor, L., van de Geijn, B., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 68

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network

Seruggia, D., Oti, M., Tripathi, P., Canver, M. C., LeBlanc, L., Di Giammartino, D. C., Bullen, M. J., Nefzger, C. M., Sun, Y. B. Y., Farouni, R., et al. (2019) · Molecular Cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 51

DNA-Diffusion: Leveraging Generative Models for Controlling Chromatin Accessibility and Gene Expression via Synthetic Regulatory Elements

DaSilva, L. F., Senan, S., Patel, Z. M., Reddy, A. J., Gabbita, S., Nussbaum, Z., Córdova, C. M. V., Wenteler, A., Weber, N., Tunjic, T. M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 32

Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification

Ryu, J., Barkal, S., Yu, T., Jankowiak, M., Zhou, Y., Francoeur, M., Phan, Q. V., Li, Z., Tognon, M., Brown, L., et al. (2023) · Nature Genetics

CRISPR and Genetic EngineeringGenomics and Rare Diseases

Cited by 32