Klickstein, Lloyd B

mTOR inhibition improves immune function in the elderly

Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine

Genetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

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TORC1 inhibition enhances immune function and reduces infections in the elderly

Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., et al. (2018) · Science Translational Medicine

PI3K/AKT/mTOR signaling in cancerGenetics, Aging, and Longevity in Model Organisms

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Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials

Mannick, J. B., Teo, G., Bernardo, P., Quinn, D., Russell, K., Klickstein, L., Marshall, W., & Shergill, S. (2021) · The Lancet Healthy Longevity

interferon and immune responsesRespiratory viral infections research

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RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes

Cherry, L. K., Li, X., Schwab, P., Lim, B., & Klickstein, L. B. (2004) · Nature Immunology

Cell Adhesion Molecules ResearchProtein Kinase Regulation and GTPase Signaling

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Measurement of MMP‐9 and ‐12 degraded elastin (ELM) provides unique information on lung tissue degradation

Skjøt-Arkil, H., Clausen, R. E., Nguyen, Q. H. T., Wang, Y., Zheng, Q., Martinez, F. J., Hogaboam, C. M., Han, M., Klickstein, L. B., Larsen, M. R., et al. (2012) · BMC Pulmonary Medicine

Protease and Inhibitor MechanismsInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

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Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

Shavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., Fan, L., Wang, Y., Iartchouk, O., Meyer, A., et al. (2018) · The Journals of Gerontology: Series A

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

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