mTOR inhibition improves immune function in the elderly

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works

Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States

Thompson, W. W., Shay, D. K., Weintraub, E., Brammer, L., Cox, N., Anderson, L. J., & Fukuda, K. (2003) · JAMA · doi:10.1001/jama.289.2.179 · Cited by 3,673 · see citing works

mTOR regulates memory CD8 T-cell differentiation

Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works

Standardizing immunophenotyping for the Human Immunology Project

Maecker, H. T., McCoy, J. P., & Nussenblatt, R. B. (2012) · Nature reviews. Immunology · doi:10.1038/nri3158 · Cited by 1,183 · see citing works

Antibody response to influenza vaccination in the elderly: A quantitative review

GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064 · see citing works

Rapamycin slows aging in mice

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Chan, C., Friedline, S., Harrison, D. E., Hejtmancik, J. F., Nadon, N. L., Strong, R., Wood, L. K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00832.x · Cited by 682 · see citing works

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chen, C., Liu, Y., Liu, Y., & Zheng, P. (2009) · Science Signaling · doi:10.1126/scisignal.2000559 · Cited by 680 · see citing works

NFATc1 Regulates PD-1 Expression upon T Cell Activation

Oestreich, K. J., Yoon, H., Ahmed, R., & Boss, J. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4832 · Cited by 416 · see citing works

The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine

Podda, A. (2001) · Vaccine · doi:10.1016/s0264-410x(00)00499-0 · Cited by 333 · see citing works

Late-life rapamycin treatment reverses age-related heart dysfunction

Flynn, J. M., O’Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B., Zykovich, A., Mooney, S. D., Strong, R., Rosen, C. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12109 · Cited by 311 · see citing works

Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data

Tanaka, C., O’Reilly, T., Kovarik, J. M., Shand, N., Hazell, K., Judson, I. R., Raymond, É., Zumstein-Mecker, S., Stephan, C., Boulay, A., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.14.1127 · Cited by 211 · see citing works

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

Erickson, J. J., Gilchuk, P., Hastings, A. K., Tollefson, S. J., Johnson, M., Downing, M. B., Boyd, K. L., Johnson, J. E., Kim, A. S., Joyce, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62860 · Cited by 203 · see citing works

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

Keating, R., Hertz, T., Wehenkel, M., Harris, T. L., Edwards, B. A., McClaren, J. L., Brown, S. A., Surman, S. L., Wilson, Z., Bradley, P. H., et al. (2013) · Nature Immunology · doi:10.1038/ni.2741 · Cited by 191 · see citing works

Stratified false discovery control for large‐scale hypothesis testing with application to genome‐wide association studies

Sun, L., Craiu, R. V., Paterson, A. D., & Bull, S. B. (2006) · Genetic Epidemiology · doi:10.1002/gepi.20164 · Cited by 149 · see citing works

Partial restoration of T‐cell function in aged mice by in vitro blockade of the PD‐1/ PD‐L1 pathway

Lages, C. S., Lewkowich, I. P., Sproles, A. A., Wills-Karp, M. A., & Chougnet, C. A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00611.x · Cited by 140 · see citing works

PD-1 + memory phenotype CD4 + T cells expressing C/EBPα underlie T cell immunodepression in senescence and leukemia

Shimatani, K., Nakashima, Y., Hattori, M., Hamazaki, Y., & Minato, N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908805106 · Cited by 134 · see citing works

The Gracefully Aging Immune System

Boraschi, D., Aguado, M. T., Dutel, C., Goronzy, J. J., Louis, J. A., Grubeck‐Loebenstein, B., Rappuoli, R., & Giudice, G. D. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005624 · Cited by 133 · see citing works

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

Ferrer, I. R., Wagener, M. E., Robertson, J. M., Turner, A., Araki, K., Ahmed, R., Kirk, A. D., Larsen, C. P., & Ford, M. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001176 · Cited by 111 · see citing works

Human circulating influenza-CD4 + ICOS1 + IL-21 + T cells expand after vaccination, exert helper function, and predict antibody responses

Spensieri, F., Borgogni, E., Zedda, L., Bardelli, M., Buricchi, F., Volpini, G., Fragapane, E., Tavarini, S., Finco, O., Rappuoli, R., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311998110 · Cited by 100 · see citing works

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice

Barns, M. E., Gondro, C., Tellam, R. L., Radley‐Crabb, H. G., Grounds, M. D., & Shavlakadze, T. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.04.025 · Cited by 84 · see citing works

Evidence of increased clinical protection of an MF59-adjuvant influenza vaccine compared to a non-adjuvant vaccine among elderly residents of long-term care facilities in Italy

Iob, A., Brianti, G., Zamparo, E., & Gallo, T. (2005) · Epidemiology and Infection · doi:10.1017/s0950268805003936 · Cited by 77 · see citing works

Preserving Youth: Does Rapamycin Deliver?

Johnson, S. C., Martin, G. M., Rabinovitch, P. S., & Kaeberlein, M. R. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007316 · Cited by 35 · see citing works

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature · doi:10.1038/s41586-018-0457-8 · Cited by 1,475 · see citing works

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389 · see citing works

The twilight of immunity: emerging concepts in aging of the immune system

Nikolich-Žugich, J. (2018) · Nature Immunology · doi:10.1038/s41590-017-0006-x · Cited by 1,240 · see citing works

Senescence and the SASP: many therapeutic avenues

Birch, J., & Gil, J. (2020) · Genes & Development · doi:10.1101/gad.343129.120 · Cited by 1,177 · see citing works

Why does COVID-19 disproportionately affect older people?

Mueller, A. L., McNamara, M. S., & Sinclair, D. A. (2020) · Aging · doi:10.18632/aging.103344 · Cited by 1,128 · see citing works

Cellular senescence: a translational perspective

Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works

An aged immune system drives senescence and ageing of solid organs

Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03547-7 · Cited by 972 · see citing works

Measuring biological aging in humans: a quest

Ferrucci, L., Gonzalez‐Freire, M., Fabbri, E., Simonsick, E., Tanaka, T., Moore, Z., Salimi, S., Sierra, F., & de Cabo, R. (2020) · Aging Cell · doi:10.1111/acel.13080 · Cited by 781 · see citing works

Metabolic Control of Longevity

López-Otín, C., Galluzzi, L., Freije, J. M. P., Madeo, F., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.07.031 · Cited by 753 · see citing works

Hallmarks of T cell aging

Mittelbrunn, M., & Kroemer, G. (2021) · Nature Immunology · doi:10.1038/s41590-021-00927-z · Cited by 702 · see citing works

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622 · see citing works

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

Weichhart, T. (2018) · Gerontology · doi:10.1159/000484629 · Cited by 596 · see citing works

The Clinical potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., & Robbins, P. D. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14969 · Cited by 539 · see citing works

The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.009 · Cited by 544 · see citing works

The role of cellular senescence in ageing and endocrine disease

Khosla, S., Farr, J. N., Tchkonia, T., & Kirkland, J. L. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0335-y · Cited by 523 · see citing works

Senescent cell clearance by the immune system: Emerging therapeutic opportunities

Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T., & Kirkland, J. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2019.04.003 · Cited by 497 · see citing works

TORC1 inhibition enhances immune function and reduces infections in the elderly

Mannick, J. B., Morris, M., Hockey, H.-U. P., Roma, G., Beibel, M., Kulmatycki, K., Watkins, M., Shavlakadze, T., Zhou, W., Quinn, D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aaq1564 · Cited by 496 · see citing works

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto, A., Ito, T. K., Pineda, V. V., LeTexier, N. J., Huang, H. Z., Sutlief, E., Tung, H., Vizzini, N., Chen, B., Smith, K., et al. (2016) · eLife · doi:10.7554/elife.16351 · Cited by 474 · see citing works

The quest to slow ageing through drug discovery

Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468 · see citing works

Control of satellite cell function in muscle regeneration and its disruption in ageing

Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476 · see citing works

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works

Targeting the biology of aging with mTOR inhibitors

Mannick, J. B., & Lamming, D. W. (2023) · Nature Aging · doi:10.1038/s43587-023-00416-y · Cited by 372 · see citing works

SARS-CoV-2, COVID-19 and the aging immune system

Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works

Healthy aging: The ultimate preventative medicine

Kaeberlein, M., Rabinovitch, P. S., & Martin, G. M. (2015) · Science · doi:10.1126/science.aad3267 · Cited by 341 · see citing works

Skin Senescence: Mechanisms and Impact on Whole-Body Aging

Franco, A. C., Aveleira, C., & Cavadas, C. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.12.003 · Cited by 321 · see citing works

Making sense of the ageing methylome

Seale, K., Horvath, S., Teschendorff, A., Eynon, N., & Voisin, S. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00477-6 · Cited by 274 · see citing works

The Genetics of Aging: A Vertebrate Perspective

Singh, P. P., Demmitt, B. A., Nath, R. D., & Brunet, A. (2019) · Cell · doi:10.1016/j.cell.2019.02.038 · Cited by 259 · see citing works

Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Fourati, S., Cristescu, R., Loboda, A., Talla, A., Filali, A., Railkar, R., Schaeffer, A. K., Favre, D., Gagnon, D., Peretz, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms10369 · Cited by 183 · see citing works

Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases

Song, S., Lam, E. W.-F., Tchkonia, T., Kirkland, J. L., & Sun, Y. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.03.008 · Cited by 195 · see citing works

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

Arriola Apelo, S. I., Neuman, J. C., Baar, E. L., Syed, F. A., Cummings, N. E., Brar, H. K., Pumper, C. P., Kimple, M. E., & Lamming, D. W. (2016) · Aging Cell · doi:10.1111/acel.12405 · Cited by 182 · see citing works

Targeting aging mechanisms: pharmacological perspectives

Moskalev, A., Guvatova, Z., Lopes, I. D. A., Beckett, C. W., Kennedy, B. K., De Magalhaes, J. P., & Makarov, A. A. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.007 · Cited by 164 · see citing works

Paradoxical changes in innate immunity in aging: recent progress and new directions

Montgomery, R. R., & Shaw, A. C. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5mr0315-104r · Cited by 147 · see citing works

Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential

Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.015 · Cited by 148 · see citing works

Immunology of the ageing kidney

Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126 · see citing works

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Juricic, P., Lu, Y.-X., Leech, T., Drews, L. F., Paulitz, J., Lu, J., Nespital, T., Azami, S., Regan, J. C., Funk, E., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00278-w · Cited by 118 · see citing works

Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy

Bektas, A., Schurman, S. H., Gonzalez-Freire, M., Dunn, C. A., Singh, A. K., Macian, F., Cuervo, A. M., Sen, R., & Ferrucci, L. (2019) · Aging · doi:10.18632/aging.102438 · Cited by 116 · see citing works

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

Walters, H. E., Deneka-Hannemann, S., & Cox, L. S. (2016) · Aging · doi:10.18632/aging.100872 · Cited by 113 · see citing works

Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging

Chambers, E. S., Vukmanovic-Stejic, M., Shih, B. B., Trahair, H., Subramanian, P., Devine, O. P., Glanville, J., Gilroy, D., Rustin, M. H. A., Freeman, T. C., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00010-6 · Cited by 96 · see citing works

The Role of Rapamycin in Healthspan Extension via the Delay of Organ Aging

Zhang, Y., Zhang, J., & Wang, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101376 · Cited by 92 · see citing works

Can blocking inflammation enhance immunity during aging?

Chambers, E. S., & Akbar, A. N. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.016 · Cited by 92 · see citing works

Impfen bei Immundefizienz: Anwendungshinweise zu den von der Ständigen Impfkommission empfohlenen Impfungen. (III) Impfen bei hämatologischen und onkologischen Erkrankungen (antineoplastische Therapie, Stammzelltransplantation), Organtransplantation und Asplenie

Laws, H.-J., Baumann, U., Bogdan, C., Burchard, G., Christopeit, M., Hecht, J., Heininger, U., Hilgendorf, I., Kern, W., Kling, K., et al. (2020) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-020-03123-w · Cited by 88 · see citing works

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85 · see citing works

Translating the Science of Aging into Therapeutic Interventions

Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78 · see citing works

Fasting and rapamycin: diabetes versus benevolent glucose intolerance

Blagosklonny, M. V. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1822-8 · Cited by 74 · see citing works

The effects of age and systemic metabolism on anti-tumor T cell responses

Drijvers, J. M., Sharpe, A. H., & Haigis, M. C. (2020) · eLife · doi:10.7554/elife.62420 · Cited by 69 · see citing works

Rapamycin Increases Mortality in<i>db/db</i>Mice, a Mouse Model of Type 2 Diabetes

Sataranatarajan, K., Ikeno, Y., Bokov, A., Feliers, D., Yalamanchili, H., Lee, H. J., Mariappan, M. M., Tabatabai-Mir, H., Diaz, V., Prasad, S., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv170 · Cited by 65 · see citing works

Considerations for successful cancer immunotherapy in aged hosts

Hurez, V, Padrón, Á. S., Svatek, R. S., & Curiel, T. J. (2016) · Clinical and Experimental Immunology · doi:10.1111/cei.12875 · Cited by 65 · see citing works

Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

Shavlakadze, T., Zhu, J., Wang, S., Zhou, W., Morin, B., Egerman, M. A., Fan, L., Wang, Y., Iartchouk, O., Meyer, A., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx249 · Cited by 59 · see citing works

The role of autophagy in axonal degeneration of the optic nerve

Koch, J. C., & Lingor, P. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.08.016 · Cited by 46 · see citing works

The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?

Austad, S. N. (2016) · Advances in Geroscience · doi:10.1007/978-3-319-23246-1_1 · Cited by 43 · see citing works

Modulation of dendritic cell and T cell cross-talk during aging: The potential role of checkpoint inhibitory molecules

Gardner, J. K., Mamotte, C. D. S., Jackaman, C., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.002 · Cited by 40 · see citing works

Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents

Verschoor, C. P., Lelic, A., Parsons, R., Evelegh, C., Bramson, J. L., Johnstone, J., Loeb, M. B., & Bowdish, D. M. E. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix257 · Cited by 31 · see citing works

Senescence in aging and disorders of the central nervous system

Swenson, B. L., Meyer, C. F., Bussian, T. J., & Baker, D. J. (2019) · Translational Medicine of Aging · doi:10.1016/j.tma.2019.01.002 · Cited by 24 · see citing works

Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks

Mallikarjun, V., & Swift, J. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.020 · Cited by 14 · see citing works

Recent advances in understanding the mechanisms determining longevity

Bayersdorf, R., & Schumacher, B. (2019) · F1000Research · doi:10.12688/f1000research.19610.1 · Cited by 14 · see citing works

Immunity, stem cells, and aging

Devaraj, E., Anbalagan, M., Ileng Kumaran, R., & Bhaskaran, N. (2021) · Stem Cells and Aging · doi:10.1016/b978-0-12-820071-1.00006-2 · Cited by 8 · see citing works

Senescence Can Be BETter without the SASP?

Vizioli, M. G., & Adams, P. D. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0485 · Cited by 6 · see citing works

Current Approaches and Future Directions for the Treatment of mTORopathies

Karalis, V., & Bateup, H. S. (2021) · Developmental Neuroscience · doi:10.1159/000515672 · Cited by 67 · see citing works

Targeting mTOR globally in cancer: Thinking beyond rapamycin

Shor, B., Gibbons, J. J., Abraham, R. T., & Yu, K. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10070 · Cited by 156 · see citing works

Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor

Artoni, F., Grützmacher, N., & Demetriades, C. (2023) · Aging Cell · doi:10.1111/acel.13888 · Cited by 25 · see citing works

The mTOR–Autophagy Axis and the Control of Metabolism

Deleyto-Seldas, N., & Efeyan, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.655731 · Cited by 360 · see citing works

Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR InhibitorPreprint

Artoni, F., Grützmacher, N., & Demetriades, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.10.519872