Wootten, Denise

Emerging paradigms in GPCR allostery: implications for drug discovery

Wootten, D., Christopoulos, A., & Sexton, P. M. (2013) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 498

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

Graaf, C. D., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J.-M., Liao, J., Fletcher, M. M., Yang, D., et al. (2016) · Pharmacological Reviews

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 403

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

Furness, S. G. B., Liang, Y.-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D., & Sexton, P. M. (2016) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 134

Allostery and biased agonism at class B G protein-coupled receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A., & Sexton, P. M. (2017) · Chemical Reviews

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 112

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A., Thompson, G., Yeasmin, M., Nawaratne, V., et al. (2023) · eLife

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 34