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Obtaining high-resolution cryo-EM structures using a common LaB6, 120-keV electron microscope equipped with a sub 200-keV optimised direct electron detectorPreprint

Venugopal, H., Mobbs, J. I., Taveneau, C., Fox, D., Vuckovic, Z., Knott, G. J., Grinter, R., Thal, D. M., Mick, S. E., Czarnik, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.26.595910 · Cited by 1 · see citing works

Allosteric Modulation of Ligand Binding to Muscarinic Receptors

Jakubík, J., & El‐Fakahany, E. E. (2024) · Neuromethods · doi:10.1007/978-1-0716-4015-9_4

Downstream Signaling of Muscarinic M4 Receptors Is Regulated by Receptor Density and Cellular Environment

Merz, M., Playle, C., Palchaudhuri, M. R., Hucke, O., Gross, U., & Ursu, D. (2025) · Pharmacology Research & Perspectives · doi:10.1002/prp2.70123

Muscarinics

Schultz, D. (2025) · Burger's Medicinal Chemistry and Drug Discovery · doi:10.1002/0471266949.bmc305

Structural basis of MK-97 positive allosteric modulation at the M 4 mAChRPreprint

Kaoullas, M. G., Mobbs, J. I., Vuckovic, Z., Belousoff, M. J., Xiao, F., Joshi, K., Wang, J., Barnes, N. W., Pham, V., Yeasmin, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.06.723386

Next-generation chemogenetic inhibition using a brain-permeant non-prescription agent

Devenish, S. O., Patel, S. D., Ussingkær, L. V., Silva, L. F. A., Goff, O., Richardson, A., Mobbs, J. I., Venugopal, H., Thal, D. M., & Kullmann, D. M. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02865-4

The Design, Synthesis and Pharmacological Characterization of Potent Xanomeline-Based M1 and M4 mAChR Bitopic Ligands

Su, Y., Pham, V., Kaoullas, M. G., Christopoulos, A., Thal, D. M., Capuano, B., Valant, C., & Scammells, P. J. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00895

Advances in enhanced sampling simulations of G-protein-coupled receptors

Joshi, K., Adediwura, V. A., & Miao, Y. (2026) · Frontiers in Chemical Biology · doi:10.3389/fchbi.2026.1943336

Atomic, structural and molecular insights into GPCR ligand binding and signalling

Nemec, K., Mészáros, B., Skiniotis, G., Blanchard, S. C., & Babu, M. M. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-026-01030-7

Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine ReceptorPreprint

Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G. V., Yeasmin, M., Nawaratne, V., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4034884 · Cited by 1 · see citing works

Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor

Xu, J. Z., Wang, Q., Hübner, H., Hu, Y., Niu, X., Wang, H., Maeda, S., Inoue, A., Tao, Y., Gmeiner, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35726-z · Cited by 44 · see citing works

Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

Burger, W. A. C., Sexton, P. M., Christopoulos, A., & Thal, D. M. (2018) · The Journal of General Physiology · doi:10.1085/jgp.201711979 · Cited by 50 · see citing works

An allosteric ligand stabilizes distinct conformations in the M2 muscarinic acetylcholine receptorPreprint

Xu, J. Z., Hübner, H., Hu, Y., Niu, X., Gmeiner, P., Jin, C., & Kobilka, B. K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.14.431178 · Cited by 3 · see citing works

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Dror, R. O., Green, H. F., Valant, C., Borhani, D. W., Valcourt, J. R., Pan, A. C., Arlow, D. H., Canals, M., Lane, J. R., Rahmani, R., et al. (2013) · Nature · doi:10.1038/nature12595 · Cited by 411 · see citing works