Fisher, David E.

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Garraway, L. A., Widlund, H. R., Rubin, M. A., Getz, G., Berger, A. J., Ramaswamy, S., Beroukhim, R., Milner, D. A., Granter, S. R., Du, J., et al. (2005) · Nature

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 1,548

Melanocyte biology and skin pigmentation

Lin, J. Y., & Fisher, D. E. (2007) · Nature

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 1,379

MITF: master regulator of melanocyte development and melanoma oncogene

Levy, C., Khaled, M., & Fisher, D. E. (2006) · Trends in Molecular Medicine

Melanoma and MAPK Pathwaysmelanin and skin pigmentation

Cited by 1,169

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Manguso, R. T., Pope, H. W., Zimmer, M. D., Brown, F. D., Yates, K. B., Miller, B. C., Collins, N. B., Bi, K., LaFleur, M. W., Juneja, V. R., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 1,147

BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma

Frederick, D. T., Piris, A., Cogdill, A. P., Cooper, Z. A., Lezcano, C., Ferrone, C. R., Mitra, D., Boni, A., Newton, L. P., Liu, C., et al. (2013) · Clinical Cancer Research

Melanoma and MAPK PathwaysCancer Immunotherapy and Biomarkers

Cited by 944

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

Haq, R., Shoag, J., Andreu-Perez, P., Yokoyama, S., Edelman, H., Rowe, G. C., Frederick, D. T., Hurley, A. D., Nellore, A., Kung, A. L., et al. (2013) · Cancer Cell

Melanoma and MAPK PathwaysCancer, Hypoxia, and Metabolism

Cited by 818

Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche

Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science

Hair Growth and Disordersmelanin and skin pigmentation

Cited by 750

Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function.

Boni, A., Cogdill, A. P., Dang, P., Udayakumar, D., Njauw, C.-N. J., Sloss, C. M., Ferrone, C. R., Flaherty, K. T., Lawrence, D. P., Fisher, D. E., et al. (2010) · Cancer Research

Melanoma and MAPK PathwaysCancer Immunotherapy and Biomarkers

Cited by 742

Intratumoral activity of the cxcr3 chemokine system is required for the efficacy of anti-PD-1 therapy

Chow, M. T., Ozga, A. J., Servis, R. L., Frederick, D. T., Lo, J. A., Fisher, D. E., Freeman, G. J., Boland, G. M., & Luster, A. D. (2019) · Immunity

Cancer Immunotherapy and BiomarkersChemokine receptors and signaling

Cited by 716

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

Hemesath, T. J., Steingrímsson, E., McGill, G., Hansen, M. J., Vaught, J., Hodgkinson, C. A., Arnheiter, H., Copeland, N. G., Jenkins, N. A., & Fisher, D. E. (1994) · Genes & Development

melanin and skin pigmentationDevelopmental Biology and Gene Regulation

Cited by 673

Central role of p53 in the suntan response and pathologic hyperpigmentation

Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell

melanin and skin pigmentationSkin Protection and Aging

Cited by 657

Precision medicine for cancer with next-generation functional diagnostics

Friedman, A. A., Letai, A., Fisher, D. E., & Flaherty, K. T. (2015) · Nature Reviews Cancer

Cancer Genomics and DiagnosticsCancer Cells and Metastasis

Cited by 570

Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

Bentires-Alj, M., Paez, J. G., David, F. S., Keilhack, H., Halmos, B., Naoki, K., Maris, J. M., Richardson, A., Bardelli, A., Sugarbaker, D. J., et al. (2004) · Cancer Research

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 509

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

Mitra, D., Luo, X., Morgan, A., Wang, J., Hoang, M. P., Lo, J., Guerrero, C. R., Lennerz, J. K., Mihm, M. C., Wargo, J. A., et al. (2012) · Nature

Melanoma and MAPK Pathwaysmelanin and skin pigmentation

Cited by 497

Melanoma: from mutations to medicine

Tsao, H., Chin, L., Garraway, L. A., & Fisher, D. E. (2012) · Genes & Development

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 496

Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion

Tateishi, K., Wakimoto, H., Iafrate, A. J., Tanaka, S., Loebel, F., Lelic, N., Wiederschain, D., Bedel, O., Deng, G., Zhang, B., et al. (2015) · Cancer Cell

Cancer, Hypoxia, and MetabolismBiochemical and Molecular Research

Cited by 433

Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

D'Orazio, J. A., Nobuhisa, T., Cui, R., Arya, M., Spry, M., Wakamatsu, K., Igras, V., Kunisada, T., Granter, S. R., Nishimura, E. K., et al. (2006) · Nature

melanin and skin pigmentationSkin Protection and Aging

Cited by 350

Integrative analysis of the melanoma transcriptome

Berger, M. F., Levin, J. Z., Vijayendran, K., Sivachenko, A., Adiconis, X., Maguire, J., Johnson, L. A., Robinson, J., Verhaak, R. G., Sougnez, C., et al. (2010) · Genome Research

Cancer Genomics and DiagnosticsCutaneous Melanoma Detection and Management

Cited by 305

Skin β-Endorphin Mediates Addiction to UV Light

Fell, G. L., Robinson, K. C., Mao, J., Woolf, C. J., & Fisher, D. E. (2014) · Cell

Neuropeptides and Animal PhysiologySkin Protection and Aging

Cited by 299

A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway

Praetorius, C., Grill, C., Stacey, S. N., Metcalf, A. M., Gorkin, D. U., Robinson, K. C., Van Otterloo, E., Kim, R. S. Q., Bergsteinsdottir, K., Ogmundsdottir, M. H., et al. (2013) · Cell

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 228

Skin pigmentation and its control: from ultraviolet radiation to stem cells

Yardman‐Frank, J. M., & Fisher, D. E. (2021) · Experimental Dermatology

melanin and skin pigmentationMelanoma and MAPK Pathways

Cited by 197

Targeting TBK1 to overcome resistance to cancer immunotherapy

Sun, Y., Revach, O.-Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., Mills, C. E., Robitschek, E. J., Davis, T. G. R., Kim, S., et al. (2023) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 174

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma

Hsiao, J. J., & Fisher, D. E. (2014) · Archives of Biochemistry and Biophysics

Melanoma and MAPK Pathwaysmelanin and skin pigmentation

Cited by 148

An Oncogenic Role for ETV1 in Melanoma

Jané-Valbuena, J., Widlund, H. R., Perner, S., Johnson, L. A., Dibner, A. C., Lin, W. M., Baker, A. C., Nazarian, R. M., Vijayendran, K. G., Sellers, W. R., et al. (2010) · Cancer Research

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

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