Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

Bentires-Alj, Mohamed; Paez, J. Guillermo; David, Frank S.; Keilhack, Heike; Halmos, Balazs; Naoki, Katsuhiko; Maris, John M.; Richardson, Andrea; Bardelli, Alberto; Sugarbaker, David J.; Richards, William G.; Du, Jinyan; Girard, Luc; Minna, John D.; Loh, Mignon L.; Fisher, David E.; Velculescu, Victor E.; Vogelstein, Bert; Meyerson, Matthew; Sellers, William R.; Neel, Benjamin G.

doi:10.1158/0008-5472.can-04-1923

Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

The SH2 domain-containing protein-tyrosine phosphatase PTPN11 (Shp2) is required for normal development and is an essential component of signaling pathways initiated by growth factors, cytokines, and extracellular matrix. In many of these pathways, Shp2 acts upstream of Ras. About 50% of patients…