Pasparakis, Manolis

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Necroptosis and its role in inflammation

Pasparakis, M., & Vandenabeele, P. (2015) · Nature

Cell death mechanisms and regulationImmune Response and Inflammation

Cited by 2,148

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

Imai, Y., Kuba, K., Neely, G. G., Yaghubian-Malhami, R., Perkmann, T., van Loo, G., Ermolaeva, M., Veldhuizen, R., Leung, Y. H. C., Wang, H., et al. (2008) · Cell

Immune Response and InflammationRespiratory Support and Mechanisms

Cited by 1,356

Synchronized renal tubular cell death involves ferroptosis

Linkermann, A., Skouta, R., Himmerkus, N., Mulay, S. R., Dewitz, C., De Zen, F., Prokai, A., Zuchtriegel, G., Krombach, F., Welz, P.-S., et al. (2014) · Proceedings of the National Academy of Sciences

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 1,126

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

Moore, R. J., Owens, D. M., Stamp, G., Arnott, C., Burke, F., East, N., Holdsworth, H., Turner, L., Rollins, B., Pasparakis, M., et al. (1999) · Nature Medicine

Inflammatory mediators and NSAID effectsCytokine Signaling Pathways and Interactions

Cited by 839

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

Ikeda, F., Deribe, Y. L., Skånland, S. S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S. J. L., Goswami, P., Nagy, V., Terzic, J., et al. (2011) · Nature

NF-κB Signaling PathwaysUbiquitin and proteasome pathways

Cited by 745

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

Ito, Y., Ofengeim, D., Najafov, A., Das, S., Saberi, S., Li, Y., Hitomi, J., Zhu, H., Chen, H., Mayo, L., et al. (2016) · Science

Amyotrophic Lateral Sclerosis ResearchCell death mechanisms and regulation

Cited by 606

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Welz, P.-S., Wullaert, A., Vlantis, K., Kondylis, V., Fernández-Majada, V., Ermolaeva, M., Kirsch, P., Sterner-Kock, A., van Loo, G., & Pasparakis, M. (2011) · Nature

Cell death mechanisms and regulationInflammatory Bowel Disease

Cited by 594

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Dannappel, M., Vlantis, K., Kumari, S., Polykratis, A., Kim, C., Wachsmuth, L., Eftychi, C., Lin, J., Corona, T., Hermance, N., et al. (2014) · Nature

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 534

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

Willenborg, S., Lucas, T., van Loo, G., Knipper, J. A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., et al. (2012) · Blood

Wound Healing and TreatmentsImmune cells in cancer

Cited by 534

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Lin, J., Kumari, S., Kim, C., Van, T.-M., Wachsmuth, L., Polykratis, A., & Pasparakis, M. (2016) · Nature

Cell death mechanisms and regulationImmune Response and Inflammation

Cited by 421

The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation

Bonnet, M. C., Preukschat, D., Welz, P.-S., van Loo, G., Ermolaeva, M. A., Bloch, W., Haase, I., & Pasparakis, M. (2011) · Immunity

Cell death mechanisms and regulationDermatology and Skin Diseases

Cited by 295

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

Vlantis, K., Wullaert, A., Polykratis, A., Kondylis, V., Dannappel, M., Schwarzer, R., Welz, P., Corona, T., Walczak, H., Weih, F., et al. (2016) · Immunity

NF-κB Signaling PathwaysInflammatory Bowel Disease

Cited by 189

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Aden, K., Tran, F., Ito, G., Sheibani-Tezerji, R., Lipinski, S., Kuiper, J. W., Tschurtschenthaler, M., Saveljeva, S., Bhattacharyya, J., Häsler, R., et al. (2018) · Journal of Experimental Medicine

Inflammatory Bowel Diseaseinterferon and immune responses

Cited by 167

Postsurgical Adjuvant Tumor Therapy by Combining Anti-Angiopoietin-2 and Metronomic Chemotherapy Limits Metastatic Growth

Srivastava, K., Hu, J., Korn, C., Savant, S., Teichert, M., Kapel, S. S., Jugold, M., Besemfelder, E., Thomas, M., Pasparakis, M., et al. (2014) · Cancer Cell

Angiogenesis and VEGF in CancerCancer Cells and Metastasis

Cited by 140

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

Kondylis, V., Polykratis, A., Ehlken, H., Ochoa-Callejero, L., Straub, B. K., Krishna-Subramanian, S., Van, T.-M., Curth, H.-M., Heise, N., Weih, F., et al. (2015) · Cancer Cell

NF-κB Signaling PathwaysCell death mechanisms and regulation

Cited by 131

IκB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-κB in the central nervous system

Raasch, J., Zeller, N., van Loo, G., Merkler, D., Mildner, A., Erny, D., Knobeloch, K.-P., Bethea, J. R., Waisman, A., Knust, M., et al. (2011) · Brain

Multiple Sclerosis Research StudiesNF-κB Signaling Pathways

Cited by 106