Sperling, Adam S.
Broad Institute · Brigham and Women's Hospital · Harvard University · Dana-Farber Cancer Institute · Dana-Farber Brigham Cancer Center
10 papers on CoChatORCID 0000-0002-9369-4413
Most cited papers
- Verified
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
Bolli, N., Avet-Loiseau, H., Wedge, D. C., Van Loo, P., Alexandrov, L. B., Martincorena, I., Dawson, K. J., Iorio, F., Nik-Zainal, S., Bignell, G. R., et al. (2014) · Nature Communications
Multiple Myeloma Research and TreatmentsCancer Genomics and Diagnostics
Cited by 875
- Verified
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Słabicki, M., Kozicka, Z., Petzold, G., Li, Y.-D., Manojkumar, M., Bunker, R. D., Donovan, K. A., Sievers, Q. L., Koeppel, J., Suchyta, D., et al. (2020) · Nature
Protein Degradation and InhibitorsUbiquitin and proteasome pathways
Cited by 433
- Verified
Small-molecule-induced polymerization triggers degradation of BCL6
Słabicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., et al. (2020) · Nature
Protein Degradation and InhibitorsUbiquitin and proteasome pathways
Cited by 270
- Verified
Association of clonal hematopoiesis with chronic obstructive pulmonary disease
Miller, P. G., Qiao, D., Rojas-Quintero, J., Honigberg, M. C., Sperling, A. S., Gibson, C. J., Bick, A. G., Niroula, A., McConkey, M. E., Sandoval, B., et al. (2022) · Blood
Chronic Obstructive Pulmonary Disease (COPD) ResearchAcute Myeloid Leukemia Research
Cited by 235
- Verified
Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells
Xie, W., Song, C., Young, N. L., Sperling, A. S., Xu, F., Sridharan, R., Conway, A. E., Garcia, B. A., Plath, K., Clark, A. T., et al. (2009) · Molecular Cell
Genomics and Chromatin DynamicsEpigenetics and DNA Methylation
Cited by 197
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Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
Jan, M., Sperling, A. S., & Ebert, B. L. (2021) · Nature Reviews Clinical Oncology
Protein Degradation and InhibitorsMultiple Myeloma Research and Treatments
Cited by 137
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UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
Tsai, J. M., Aguirre, J. D., Li, Y.-D., Brown, J., Focht, V., Kater, L., Kempf, G., Sandoval, B., Schmitt, S., Rutter, J. C., et al. (2023) · Molecular Cell
Estrogen and related hormone effectsUbiquitin and proteasome pathways
Cited by 68
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Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216
Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., et al. (2022) · Journal of Medicinal Chemistry
Protein Degradation and InhibitorsChemical Synthesis and Analysis
Cited by 63
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Immuno-PRISM: A Randomized Phase II Platform Study of Bispecific Antibodies in High-Risk Smoldering Myeloma
Nadeem, O., Magidson, S., Midha, S., O'Donnell, E. K., Hartley-Brown, M. A., Sperling, A. S., Redd, R. A., Marto, M., Davie, C., Ricciardi, C., et al. (2023) · Blood
Multiple Myeloma Research and TreatmentsMonoclonal and Polyclonal Antibodies Research
Cited by 37
- Verified
A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia
DeAngelo, D. J., Brunner, A. M., Werner, L., Avigan, D., Fathi, A. T., Sperling, A. S., Washington, A., Stroopinsky, D., Rosenblatt, J., McMasters, M., et al. (2018) · American Journal of Hematology
Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes
Cited by 16
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