Hendel, Ayal

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

Hendel, A., Bak, R. O., Clark, J. T., Kennedy, A. B., Ryan, D. E., Roy, S., Steinfeld, I., Lunstad, B. D., Kaiser, R. J., Wilkens, A. B., et al. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,090

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Dever, D. P., Bak, R. O., Reinisch, A., Camarena, J., Washington, G., Nicolas, C. E., Pavel-Dinu, M., Saxena, N., Wilkens, A. B., Mantri, S., et al. (2016) · Nature

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 864

Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification

Vaidyanathan, S., Azizian, K. T., Haque, A. K. M. A., Henderson, J. M., Hendel, A., Shore, S., Antony, J. S., Hogrefe, R. I., Kormann, M. S. D., Porteus, M. H., et al. (2018) · Molecular Therapy Nucleic Acids

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 262

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells

Hendel, A., Krijger, P. H. L., Diamant, N., Goren, Z., Langerak, P., Kim, J., Reißner, T., Lee, K.-Y., Geacintov, N. E., Carell, T., et al. (2011) · PLoS Genetics

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 132

DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

Diamant, N., Hendel, A., Vered, I., Carell, T., Reißner, T., de Wind, N., Geacinov, N., & Livneh, Z. (2012) · Nucleic Acids Research

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 109

Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells

Jansen, J. G., Tsaalbi-Shtylik, A., Hendriks, G., Gali, H., Hendel, A., Johansson, F., Erixon, K., Livneh, Z., Mullenders, L. H. F., Haracska, L., et al. (2009) · Molecular and Cellular Biology

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 99