Holmgren, Arne

The thioredoxin antioxidant system

Lu, J., & Holmgren, A. (2014) · Free Radical Biology and Medicine

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 2,055

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 836

Thioredoxin and Related Molecules–From Biology to Health and Disease

Lillig, C. H., & Holmgren, A. (2007) · Antioxidants & Redox Signaling

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 724

The thioredoxin system in cancer

Arnér, E. S. J., & Holmgren, A. (2006) · Seminars in Cancer Biology

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 589

Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

Lu, J., Chew, E.-H., & Holmgren, A. (2007) · Proceedings of the National Academy of Sciences

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 526

Thioredoxin Reductase Is Irreversibly Modified by Curcumin

Fang, J., Lu, J., & Holmgren, A. (2005) · Journal of Biological Chemistry

Redox biology and oxidative stressCurcumin's Biomedical Applications

Cited by 521

Inhibition of Mammalian Thioredoxin Reductase by Some Flavonoids: Implications for Myricetin and Quercetin Anticancer Activity

Lu, J., Papp, L. V., Fang, J., Rodriguez-Nieto, S., Zhivotovsky, B., & Holmgren, A. (2006) · Cancer Research

Redox biology and oxidative stressBioactive Compounds and Antitumor Agents

Cited by 326

Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase

Johansson, C., Lillig, C. H., & Holmgren, A. (2004) · Journal of Biological Chemistry

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 320

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

Schoenmakers, E., Agostini, M., Mitchell, C., Schoenmakers, N., Papp, L., Rajanayagam, O., Padidela, R., Ceron-Gutierrez, L., Doffinger, R., Prevosto, C., et al. (2010) · Journal of Clinical Investigation

Selenium in Biological SystemsOrganoselenium and organotellurium chemistry

Cited by 315

Thioredoxin System in Cell Death Progression

Lu, J., & Holmgren, A. (2012) · Antioxidants & Redox Signaling

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 279

Glutathione and Glutaredoxin Act as a Backup of Human Thioredoxin Reductase 1 to Reduce Thioredoxin 1 Preventing Cell Death by Aurothioglucose

Du, Y., Zhang, H., Lu, J., & Holmgren, A. (2012) · Journal of Biological Chemistry

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 230

Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues

Hashemy, S. I., & Holmgren, A. (2008) · Journal of Biological Chemistry

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 192

Molecular Mechanisms of Thioredoxin and Glutaredoxin as Hydrogen Donors for Mammalian S Phase Ribonucleotide Reductase

Avval, F. Z., & Holmgren, A. (2009) · Journal of Biological Chemistry

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 169

Thioredoxin and Thioredoxin Reductase in Relation to Reversible S -Nitrosylation

Sengupta, R., & Holmgren, A. (2013) · Antioxidants & Redox Signaling

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 156

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide

Lillig, C. H., Lönn, M. E., Enoksson, M., Fernandes, A. P., & Holmgren, A. (2004) · Proceedings of the National Academy of Sciences

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 147

Thioredoxin 1 Is Inactivated Due to Oxidation Induced by Peroxiredoxin under Oxidative Stress and Reactivated by the Glutaredoxin System

Du, Y., Zhang, H., Zhang, X., Lu, J., & Holmgren, A. (2013) · Journal of Biological Chemistry

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 117

The use of thiols by ribonucleotide reductase

Holmgren, A., & Sengupta, R. (2010) · Free Radical Biology and Medicine

Metal-Catalyzed Oxygenation MechanismsRedox biology and oxidative stress

Cited by 116

The role of thioredoxin in the regulation of cellular processes by S-nitrosylation

Sengupta, R., & Holmgren, A. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects

Redox biology and oxidative stressNitric Oxide and Endothelin Effects

Cited by 110

Visualization of the compartmentalization of glutathione and protein‐glutathione mixed disulfides in cultured cells

Söderdahl, T., Enoksson, M., Lundberg, M., Holmgren, A., Ottersen, O. P., Orrenius, S., Bolcsfoldi, G., & Cotgreave, I. A. (2003) · The FASEB Journal

Sulfur Compounds in BiologyRedox biology and oxidative stress

Cited by 99

Inhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246

Haffo, L., Lu, J., Bykov, V. J. N., Martin, S. S., Ren, X., Coppo, L., Wiman, K. G., & Holmgren, A. (2018) · Scientific Reports

Redox biology and oxidative stressCancer-related Molecular Pathways

Cited by 73