Engert, James C.

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Exome Sequencing, ANGPTL3 Mutations, and Familial Combined Hypolipidemia

Musunuru, K., Pirruccello, J. P., Do, R., Peloso, G. M., Guiducci, C., Sougnez, C., Garimella, K. V., Fisher, S., Abreu, J., Barry, A. J., et al. (2010) · New England Journal of Medicine

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 754

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Mahajan, A., Spracklen, C. N., Zhang, W., Ng, M. C. Y., Petty, L. E., Kitajima, H., Yu, G. Z., Rüeger, S., Speidel, L., Kim, Y. J., et al. (2022) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Genetic drivers of heterogeneity in type 2 diabetes pathophysiology

Suzuki, K., Hatzikotoulas, K., Southam, L., Taylor, H. J., Yin, X., Lorenz, K. M., Mandla, R., Huerta-Chagoya, A., Melloni, G. E. M., Kanoni, S., et al. (2024) · Nature

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 606

ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF

Engert, J. C., Bérubé, P., Mercier, J., Doré, C., Lepage, P., Ge, B., Bouchard, J.-P., Mathieu, J., Melançon, S. B., Schalling, M., et al. (2000) · Nature Genetics

Genetic Neurodegenerative DiseasesHereditary Neurological Disorders

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Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis

Smith, J. G., Luk, K., Schulz, C.-A., Engert, J. C., Do, R., Hindy, G., Rukh, G., Dufresne, L., Almgren, P., Owens, D. S., et al. (2014) · JAMA

Cardiac Valve Diseases and TreatmentsLipoproteins and Cardiovascular Health

Cited by 238

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Voight, B. F., Peloso, G. M., Orho-Melander, M., Frikke-Schmidt, R., Barbalic, M., Jensen, M. K., Hindy, G., Hólm, H., Ding, E. L., Johnson, T., et al. (2012) · The Lancet

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

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The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression

Samaan, Z., Anand, S., Zhang, X., Desai, D., Rivera, M., Pare, G., Thabane, L., Xie, C., Gerstein, H., Engert, J. C., et al. (2013) · Molecular Psychiatry

Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on Behavior

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Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study

Yu Chen, H., Dina, C., Small, A. M., Shaffer, C. M., Levinson, R. T., Helgadóttir, A., Capoulade, R., Munter, H. M., Martinsson, A., Cairns, B. J., et al. (2023) · European Heart Journal

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 116

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis

Perrot, N., Valerio, V., Moschetta, D., Boekholdt, S. M., Dina, C., Chen, H. Y., Abner, E., Martinsson, A., Manikpurage, H. D., Rigade, S., et al. (2020) · JACC: Basic to Translational Science

Cardiac Valve Diseases and TreatmentsDermatological and Skeletal Disorders

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Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis

Chen, H. Y., Cairns, B. J., Small, A. M., Burr, H. A., Ambikkumar, A., Martinsson, A., Thériault, S., Munter, H. M., Steffen, B., Zhang, R., et al. (2020) · JAMA Cardiology

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 65

Large-scale proteomics identifies novel biomarkers and circulating risk factors for aortic stenosis

Shelbaya, K., Arthur, V., Yang, Y., Dorbala, P., Buckley, L., Claggett, B., Skali, H., Dufresne, L., Yang, T.-Y., Engert, J. C., et al. (2024) · Journal of the American College of Cardiology

Cardiac Valve Diseases and TreatmentsAdvanced Proteomics Techniques and Applications

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Genetic Variants and Early Cigarette Smoking and Nicotine Dependence Phenotypes in Adolescents

O'Loughlin, J., Sylvestre, M.-P., Labbe, A., Low, N. C., Roy-Gagnon, M.-H., Dugas, E. N., Karp, I., & Engert, J. C. (2014) · PLoS ONE

Smoking Behavior and CessationGenetic Associations and Epidemiology

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Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Small, A. M., Yang, T.-Y., Itoh, S., Thériault, S., Dufresne, L., Kurosawa, R., Komuro, I., Matsuda, K., Vy, H. M. T., Farber-Eger, E. H., et al. (2026) · Nature Genetics

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

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