Cited by 129Genetic Associations and EpidemiologyNeurotransmitter Receptor Influence on BehaviorGenetics and Physical Performance

The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression

Samaan, Z, Anand, S, Zhang, X, Desai, D, Rivera, M, Pare, G, Thabane, L, Xie, C +16 more·2013·Molecular Psychiatry

Abstract

Candidate gene and genome-wide association studies have not identified common variants, which are reliably associated with depression. The recent identification of obesity predisposing genes that are highly expressed in the brain raises the possibility of their genetic contribution to depression. As variation in the intron 1 of the fat mass- and obesity-associated (FTO) gene contributes to polygenic obesity, we assessed the possibility that FTO gene may contribute to depression in a cross-sectional multi-ethnic sample of 6561 depression cases and 21,932 controls selected from the EpiDREAM, INTERHEART, DeCC (depression case-control study) and Cohorte Lausannoise (CoLaus) studies. Major depression was defined according to DSM IV diagnostic criteria. Association analyses were performed under the additive genetic model. A meta-analysis of the four studies showed a significant inverse association between the obesity risk FTO rs9939609 A variant and depression (odds ratio=0.92 (0.89, 0.97), P=3 × 10(-4)) adjusted for age, sex, ethnicity/population structure and body-mass index (BMI) with no significant between-study heterogeneity (I(2)=0%, P=0.63). The FTO rs9939609 A variant was also associated with increased BMI in the four studies (β 0.30 (0.08, 0.51), P=0.0064) adjusted for age, sex and ethnicity/population structure. In conclusion, we provide the first evidence that the FTO rs9939609 A variant may be associated with a lower risk of depression independently of its effect on BMI…

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Crossref · 10.1038/mp.2012.160

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Authors
Samaan, Z., Anand, S., Zhang, X., Desai, D., Rivera, M., Pare, G., Thabane, L., Xie, C., Gerstein, H., Engert, J. C., Craig, I., Cohen-Woods, S., Mohan, V, Diaz, R., Wang, X., Liu, L., Corre, T., Preisig, M., Kutalik, Z., Bergmann, S., Vollenweider, P., Waeber, G., Yusuf, S., & Meyre, D.
Affiliations
  • Population Health Research Institute (CA)
  • Universidad de Granada (ES)
  • McGill University (CA)
  • Madras Diabetes Research Foundation (IN)
  • SIB Swiss Institute of Bioinformatics (CH)
  • Centre Hospitalier Universitaire Vaudois (CH)
  • McMaster University (CA)
Corresponding author
Meyre, D
Venue
Molecular Psychiatry
Published
2012-11-20
Volume
18
Issue
12
Pages
1281-1286
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2015751650
Cited by
129
References
51
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 13 · 2022: 6 · 2021: 36 · 2020: 9 · 2019: 7 · 2018: 3 · 2017: 10 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 5
FWCI
4.80
Type
journal article
Language
en
Update notices
erratum (2013-03-05)
Open access
closed
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • IRIS (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • Canada Research Chairs
  • Hamilton Health Sciences Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
Keywords
depression, FTO, rs9939609, fat mass and obesity-associated gene, body mass index, genetic association, major depressive disorder, polygenic obesity
MeSH terms
Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Depression, Major Depressive Disorder, Female, Genotype, Humans, Male, Middle Aged, Obesity, Phenotype, Proteins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

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