Xia, Weiming

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Citron, M., Westaway, D., Xia, W., Carlson, G., Diehl, T., Levesque, G., Johnson-wood, K., Lee, M., Seubert, P., Davis, A., et al. (1997) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,271

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

Shen, J., Bronson, R. T., Chen, D. F., Xia, W., Selkoe, D. J., & Tonegawa, S. (1997) · Cell

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 959

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 729

Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration

Salehi, A., Delcroix, J.-D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., et al. (2006) · Neuron

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 543

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Pastorino, L., Sun, A., Lu, P.-J., Zhou, X. Z., Balastik, M., Finn, G., Wulf, G., Lim, J., Li, S.-H., Li, X., et al. (2006) · Nature

Alzheimer's disease research and treatmentsSignaling Pathways in Disease

Cited by 487

Beta-amyloid deposition in chronic traumatic encephalopathy

Stein, T. D., Montenigro, P. H., Alvarez, V. E., Xia, W., Crary, J. F., Tripodis, Y., Daneshvar, D. H., Mez, J., Solomon, T., Meng, G., et al. (2015) · Acta Neuropathologica

Traumatic Brain Injury ResearchAlzheimer's disease research and treatments

Cited by 291

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

Wolfe, M. S., Xia, W., Moore, C. L., Leatherwood, D. D., Ostaszewski, B., Rahmati, T., Donkor, I. O., & Selkoe, D. J. (1999) · Biochemistry

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 289

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

Lee, H.-K., Velazquez Sanchez, C., Chen, M., Morin, P. J., Wells, J. M., Hanlon, E. B., & Xia, W. (2016) · PLOS ONE

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 190

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

Kwak, S. S., Washicosky, K. J., Brand, E., von Maydell, D., Aronson, J., Kim, S., Capen, D. E., Cetinbas, M., Sadreyev, R., Ning, S., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 151

Lewy body pathology and chronic traumatic encephalopathy associated with contact sports

Adams, J. W., Alvarez, V. E., Mez, J., Huber, B. R., Tripodis, Y., Xia, W., Meng, G., Kubilus, C. A., Cormier, K., Kiernan, P. T., et al. (2018) · Journal of Neuropathology & Experimental Neurology

Traumatic Brain Injury ResearchParkinson's Disease Mechanisms and Treatments

Cited by 109

Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Citron, M., Eckman, C. B., Diehl, T. S., Corcoran, C., Ostaszewski, B. L., Xia, W., Levesque, G., St. George Hyslop, P., Younkin, S. G., & Selkoe, D. J. (1998) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 101

Presenilin‐1 Exists in Both Pre‐ and Post‐Golgi Compartments and Recycles Via COPI‐Coated Membranes

Réchards, M., Xia, W., Oorschot, V. M. J., Selkoe, D. J., & Klumperman, J. (2003) · Traffic

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 55

γ-Secretase and its modulators: Twenty years and beyond

Xia, W. (2019) · Neuroscience Letters

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 54

Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid β protein

Zhao, H., Zhu, J., Cui, K., Xu, X., O'Brien, M., Wong, K. K., Kesari, S., Xia, W., & Wong, S. T. (2009) · Cancer Cell International

Alzheimer's disease research and treatmentsGlioma Diagnosis and Treatment

Cited by 33

β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease

Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Libera, J., Wang, Z., Kilci, A., Jenkins, M., Ortiz, A. R., et al. (2024) · Frontiers in Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 15