The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

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Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

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Function of WW Domains as Phosphoserine- or Phosphothreonine-Binding Modules

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Pin1-Dependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Proteins

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APP processing is regulated by cytoplasmic phosphorylation

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Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

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Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis

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Pinning down cell signaling, cancer and Alzheimer's disease

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Cell cycle‐dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

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Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis

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Pin1 Acts Catalytically to Promote a Conformational Change in Cdc25

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Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition

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1H NMR Study on the Binding of Pin1 Trp-Trp Domain with Phosphothreonine Peptides

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Pin1 Regulates Centrosome Duplication, and Its Overexpression Induces Centrosome Amplification, Chromosome Instability, and Oncogenesis

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BACE (β-secretase) modulates the processing of APLP2 in vivo

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PIN1 promoter polymorphisms are associated with Alzheimer's disease

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Evidence for a Novel Late-Onset Alzheimer Disease Locus on Chromosome 19p13.2

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Proline‐directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

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Transient Structure of the Amyloid Precursor Protein Cytoplasmic Tail Indicates Preordering of Structure for Binding to Cytosolic Factors

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Pin1 promotes production of Alzheimer’s amyloid β from β-cleaved amyloid precursor protein

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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

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The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

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Animal models of Alzheimer's disease and frontotemporal dementia

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Prolyl cis-trans isomerization as a molecular timer

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Post-translational modifications of tau protein: Implications for Alzheimer's disease

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Roles of amyloid β-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

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Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

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The amyloid precursor protein: beyond amyloid.

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Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

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Elevation of Glutathione as a Therapeutic Strategy in Alzheimer Disease

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Biology and pathophysiology of the amyloid precursor protein

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Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer’s disease risk factor

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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

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Role of Oxidative Stress in the Progression of Alzheimer's Disease

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Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

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Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis

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Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

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The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

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Substrate specificity of γ-secretase and other intramembrane proteases

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PIN1, the cell cycle and cancer

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Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer's Disease

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Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

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JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

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Proteomics Analysis of the Alzheimer's Disease Hippocampal Proteome

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Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

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The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules

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Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy

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Co-Localization of Amyloid Beta and Tau Pathology in Alzheimer's Disease Synaptosomes

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Prolyl isomerase Pin1 in cancer

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Multivesicular bodies in neurons: Distribution, protein content, and trafficking functions

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Tau local structure shields an amyloid-forming motif and controls aggregation propensity

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Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts

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Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

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Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

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Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

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A Common Biological Mechanism in Cancer and Alzheimers Disease?

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Proline cis-trans Isomerization Controls Autoinhibition of a Signaling Protein

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Effects of in vivo conditions on amyloid aggregation

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Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

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REVIEW: Pin1 in Alzheimer's disease

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Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?

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Inflammation and NF-κB in Alzheimer's Disease and Diabetes

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A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis *

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The emerging role of glutathione in Alzheimer’s disease

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The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

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Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

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Cholinergic‐associated loss of hnRNP‐A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

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Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

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Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

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Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

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Co‐ and Post‐Translational Protein Folding in the ER

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Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

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Pin1 Interacts With a Specific Serine-Proline Motif of Hepatitis B Virus X-Protein to Enhance Hepatocarcinogenesis

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Cancer and Alzheimer’s disease inverse relationship: an age-associated diverging derailment of shared pathways

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Critical Role of the Proline-rich Region in Huntingtin for Aggregation and Cytotoxicity in Yeast

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Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators

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Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Alzheimer's Disease and Mild Cognitive Impairment: Insights into the Progression of this Dementing Disorder

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Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

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Peptidyl-prolyl isomerization targets rice Aux/IAAs for proteasomal degradation during auxin signalling

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Endosomal transport of neurotrophins: Roles in signaling and neurodegenerative diseases

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Advances in MicroRNA Therapeutics: From Preclinical to Clinical Studies

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Tau Phosphorylation by GSK3 in Different Conditions

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Disease modifying therapy for AD?¹

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Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives

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Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy

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Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

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Death‐associated protein kinase (DAPK) family modulators: Current and future therapeutic outcomes

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Phosphorylation Signaling in APP Processing in Alzheimer’s Disease

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Altered lipid metabolism in a Drosophila model of Friedreich's ataxia

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Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

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Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease

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Molecular crosstalk between cancer and neurodegenerative diseases

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Protein aggregation as a paradigm of aging

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Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention

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Essential Role of Proline Isomerization in Stefin B Tetramer Formation

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Pin1 inhibitors: Pitfalls, progress and cellular pharmacology

Moore, J. D., & Potter, A. J. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.05.088 · Cited by 105 · see citing works

Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila

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Post‐phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function

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The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains

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Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

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Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

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Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer’s Disease

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The emerging roles of protein homeostasis‐governing pathways in Alzheimer's disease

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De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system

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The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease

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Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

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The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

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Pin1 in Alzheimer's disease: Multiple substrates, one regulatory mechanism?

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Targeting Aβ and tau in Alzheimer's disease, an early interim report

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Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer’s disease

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Potential in vivo amelioration by N‐acetyl‐L‐cysteine of oxidative stress in brain in human double mutant APP/PS‐1 knock‐in mice: Toward therapeutic modulation of mild cognitive impairment

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Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease

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Structural basis for regulation of the Crk signaling protein by a proline switch

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Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65‐PTB2

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Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer's disease

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REVIEW Pin1 in Alzheimer’s disease D. Allan Butterfield,*,, Hafiz Mohmmad Abdul,*, Wycliffe Opii,*,

Newman, S. F., Gururaj Joshi, A., Ansari, M. A., & Rukhsana Sultana, A. (2015)

Pin-pointing APP Processing

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REVIEW: Pin1 in Alzheimer's disease

Butterfield, D. A., Abdul, H. M., Opii, W. O., Newman, S. F., Gururaj Joshi, A., Ansari, M. A., & Rukhsana Sultana, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03995.x · Cited by 179 · see citing works

Pin1 in Alzheimer's disease: Multiple substrates, one regulatory mechanism?

Balaštík, M., Lim, J., Pastorino, L., & Lu, K. P. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.01.006 · Cited by 90 · see citing works

Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer’s Disease

Wang, L., Zhou, Y., Chen, D., & Lee, T. H. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00355 · Cited by 61 · see citing works