Cited by 729Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Yang, Li-Bang, Lindholm, Kristina, Yan, Riqiang, Citron, Martin, Xia, Weiming, Yang, Xiao-Li, Beach, Thomas, Sue, Lucia +4 more·2003·Nature Medicine

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Crossref · 10.1038/nm0103-3

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3 of 3 references verified0 citation errors · 0 not checkable

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  • BACE1 expression is elevated in cortices of AD patients compared to age-matched, non-demented controls.

    “Post-mortem analyses revealed that BACE1 expression is elevated in cortices of AD patients compared to the age-matched, non-demented controls (Fukumoto et al. 2002, Yang et al. 2003, Hebert et al. 2008, Ahmed et al. 2010).”

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Authors
Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., Li, R., & Shen, Y.
Affiliations
  • Banner Sun Health Research Institute (US)
  • Pfizer (United States) (US)
  • Amgen (United States) (US)
  • Brigham and Women's Hospital (US)
  • Johns Hopkins University (US)
Corresponding author
Shen, Yong
Venue
Nature Medicine
Published
2003-01
Volume
9
Issue
1
Pages
3-4
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2047418563
Cited by
729
References
3
Citations by year
2026: 8 · 2025: 25 · 2024: 24 · 2023: 25 · 2022: 26 · 2021: 23 · 2020: 38 · 2019: 31 · 2018: 33 · 2017: 32 · 2016: 39 · 2015: 40 · 2014: 36 · 2013: 42 · 2012: 51
FWCI
18.39
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
beta-secretase, BACE1, sporadic Alzheimer's disease, amyloid-beta production, amyloid precursor protein, NCAM2, enzyme activity
MeSH terms
Alzheimer Disease, Enzyme-Linked Immunosorbent Assay, Humans, Mutation, Endopeptidases, Statistics as Topic, Temporal Lobe, Transfection, Aspartic Acid Endopeptidases, Amyloid Precursor Protein Secretases

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