Ploegh, Hidde L.

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

Gilbert, L. A., Horlbeck, M. A., Adamson, B., Villalta, J. E., Chen, Y., Whitehead, E. H., Guimaraes, C., Panning, B., Ploegh, H. L., Bassik, M. C., et al. (2014) · Cell

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 2,728

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

Maruyama, T., Dougan, S. K., Truttmann, M. C., Bilate, A. M., Ingram, J. R., & Ploegh, H. L. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 1,137

A guide to antigen processing and presentation

Pishesha, N., Harmand, T. J., & Ploegh, H. L. (2022) · Nature Reviews Immunology

Immunotherapy and Immune Responsesvaccines and immunoinformatics approaches

Cited by 805

An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration

Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulation

Cited by 786

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Huang, Y.-H., Zhu, C., Kondo, Y., Anderson, A. C., Gandhi, A., Russell, A., Dougan, S. K., Petersen, B.-S., Melum, E., Pertel, T., et al. (2015) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 717

Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

Borodovsky, A., Ovaa, H., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Ploegh, H. L., & Kessler, B. M. (2002) · Chemistry & Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 588

The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP

Ahn, K., Gruhler, A., Galocha, B., Jones, T. R., Wiertz, E. J. H. J., Ploegh, H. L., Peterson, P. A., Yang, Y., & Früh, K. (1997) · Immunity

Cytomegalovirus and herpesvirus researchHerpesvirus Infections and Treatments

Cited by 477

Protection of tissue physicochemical properties using polyfunctional crosslinkers

Park, Y.-G., Sohn, C. H., Chen, R., McCue, M., Yun, D. H., Drummond, G. T., Ku, T., Evans, N. B., Oak, H. C., Trieu, W., et al. (2019) · Nature Biotechnology

Single-cell and spatial transcriptomicsAdvanced Fluorescence Microscopy Techniques

Cited by 421

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

Chahal, J. S., Khan, O. F., Cooper, C. L., McPartlan, J. S., Tsosie, J. K., Tilley, L. D., Sidik, S. M., Lourido, S., Langer, R., Bavari, S., et al. (2016) · Proceedings of the National Academy of Sciences

Immunotherapy and Immune ResponsesDendrimers and Hyperbranched Polymers

Cited by 414

Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas

Dongre, A., Rashidian, M., Reinhardt, F., Bagnato, A., Keckesova, Z., Ploegh, H. L., & Weinberg, R. A. (2017) · Cancer Research

Cancer Cells and MetastasisCancer Immunotherapy and Biomarkers

Cited by 395

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

Sockolosky, J. T., Dougan, M., Ingram, J. R., Ho, C. C. M., Kauke, M. J., Almo, S. C., Ploegh, H. L., & Garcia, K. C. (2016) · Proceedings of the National Academy of Sciences

Phagocytosis and Immune RegulationCancer Immunotherapy and Biomarkers

Cited by 366

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

Felbor, U., Kessler, B., Mothes, W., Goebel, H. H., Ploegh, H. L., Bronson, R. T., & Olsen, B. R. (2002) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsCalpain Protease Function and Regulation

Cited by 334

Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host

Buti, L., Spooner, E., Van der Veen, A. G., Rappuoli, R., Covacci, A., & Ploegh, H. L. (2011) · Proceedings of the National Academy of Sciences

Helicobacter pylori-related gastroenterology studiesCancer-related Molecular Pathways

Cited by 253

In vivo discovery of immunotherapy targets in the tumour microenvironment

Zhou, P., Shaffer, D. R., Alvarez Arias, D. A., Nakazaki, Y., Pos, W., Torres, A. J., Cremasco, V., Dougan, S. K., Cowley, G. S., Elpek, K., et al. (2014) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 237

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Priem, B., van Leent, M. M. T., Teunissen, A. J. P., Sofias, A. M., Mourits, V. P., Willemsen, L., Klein, E. D., Oosterwijk, R. S., Meerwaldt, A. E., Munitz, J., et al. (2020) · Cell

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 222

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

Ovaa, H., Kessler, B. M., Rolén, U., Galardy, P. J., Ploegh, H. L., & Masucci, M. G. (2004) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 190

A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., Starnbach, M. N., & Sabatini, D. M. (2013) · Nature Cell Biology

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

Cited by 169

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

Kessler, B. M., Tortorella, D., Altun, M., Kisselev, A. F., Fiebiger, E., Hekking, B. G., Ploegh, H. L., & Overkleeft, H. S. (2001) · Chemistry & Biology

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 163

Quality and quantity control at the endoplasmic reticulum

Hegde, R. S., & Ploegh, H. L. (2010) · Current Opinion in Cell Biology

Endoplasmic Reticulum Stress and DiseaseCellular transport and secretion

Cited by 157

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell‐cycle progression and stress tolerance

Ryu, K., Maehr, R., Gilchrist, C. A., Long, M. A., Bouley, D. M., Mueller, B., Ploegh, H. L., & Kopito, R. R. (2007) · The EMBO Journal

Ubiquitin and proteasome pathwaysAutophagy in Disease and Therapy

Cited by 156

Identification of Proteins Associated with Murine Cytomegalovirus Virions

Kattenhorn, L. M., Mills, R., Wagner, M., Lomsadze, A., Makeev, V., Borodovsky, M., Ploegh, H. L., & Kessler, B. M. (2004) · Journal of Virology

Cytomegalovirus and herpesvirus researchAdvanced Proteomics Techniques and Applications

Cited by 147

Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification

Artavanis-Tsakonas, K., Love, J. C., Ploegh, H. L., & Vyas, J. M. (2006) · Proceedings of the National Academy of Sciences

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 63

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

Greer, P. L., Hanayama, R., Bloodgood, B. L., Mardinly, A. R., Lipton, D. M., Flavell, S. W., Kim, T.-K., Griffith, E. C., Waldon, Z., Maehr, R., et al. (2010) · Cell

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 30