Lombard, David B.

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 1,687

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell

Sirtuins and Resveratrol in MedicineDNA Repair Mechanisms

Cited by 1,637

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology

Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

Cited by 1,216

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

Park, J., Chen, Y., Tishkoff, D. X., Peng, C., Tan, M., Dai, L., Xie, Z., Zhang, Y., Zwaans, B. M. M., Skinner, M. E., et al. (2013) · Molecular Cell

Sirtuins and Resveratrol in MedicineCancer-related gene regulation

Cited by 1,000

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell

Genetics, Aging, and Longevity in Model OrganismsDNA Repair Mechanisms

Cited by 944

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

Tan, M., Peng, C., Anderson, K. A., Chhoy, P., Xie, Z., Dai, L., Park, J., Chen, Y., Huang, H., Zhang, Y., et al. (2014) · Cell Metabolism

Sirtuins and Resveratrol in MedicineCancer-related gene regulation

Cited by 844

The first identification of lysine malonylation substrates and its regulatory enzyme

Peng, C., Lu, Z., Xie, Z., Cheng, Z., Chen, Y., Tan, M., Luo, H., Zhang, Y., He, W., Yang, K., et al. (2011) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsCancer-related gene regulation

Cited by 751

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

Xie, Z., Zhang, D., Chung, D., Tang, Z., Huang, H., Dai, L., Qi, S., Li, J., Colak, G., Chen, Y., et al. (2016) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 744

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Sebastián, C., Zwaans, B. M. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., et al. (2012) · Cell

Sirtuins and Resveratrol in MedicineCancer, Hypoxia, and Metabolism

Cited by 660

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

Zhang, Y., Kwon, S., Yamaguchi, T., Cubizolles, F., Rousseaux, S., Kneissel, M., Cao, C., Li, N., Cheng, H.-L., Chua, K., et al. (2008) · Molecular and Cellular Biology

Histone Deacetylase Inhibitors ResearchMicrotubule and mitosis dynamics

Cited by 559

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

Shimazu, T., Hirschey, M. D., Hua, L., Dittenhafer-Reed, K. E., Schwer, B., Lombard, D. B., Li, Y., Bunkenborg, J., Alt, F. W., Denu, J. M., et al. (2010) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 484

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

Jing, E., Emanuelli, B., Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M., & Kahn, C. R. (2011) · Proceedings of the National Academy of Sciences

Sirtuins and Resveratrol in MedicineMetabolism, Diabetes, and Cancer

Cited by 469

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 462

H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

Franco, S., Gostissa, M., Zha, S., Lombard, D. B., Murphy, M. M., Zarrin, A. A., Yan, C., Tepsuporn, S., Morales, J. C., Adams, M. M., et al. (2006) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 282

Calorie restriction alters mitochondrial protein acetylation

Schwer, B., Eckersdorff, M., Li, Y., Silva, J. C., Fermin, D., Kurtev, M. V., Giallourakis, C., Comb, M. J., Alt, F. W., & Lombard, D. B. (2009) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 259

Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background

Lombard, D. B., Beard, C., Johnson, B., Marciniak, R. A., Dausman, J., Bronson, R., Buhlmann, J. E., Lipman, R., Curry, R., Sharpe, A., et al. (2000) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 187

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

Kerk, S. A., Lin, L., Myers, A. L., Sutton, D. J., Andren, A., Sajjakulnukit, P., Zhang, L., Zhang, Y., Jiménez, J. A., Nelson, B. S., et al. (2022) · eLife

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 108

High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions

Little, A. C., Kovalenko, I., Goo, L. E., Hong, H. S., Kerk, S. A., Yates, J. A., Purohit, V., Lombard, D. B., Merajver, S. D., & Lyssiotis, C. A. (2020) · Communications Biology

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 88