The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

BEDTools: a flexible suite of utilities for comparing genomic features

Quinlan, A. R., & Hall, I. M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq033 · Cited by 27,437 · see citing works

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556 · see citing works

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

TopHat: discovering splice junctions with RNA-Seq

Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,477 · see citing works

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950 · see citing works

The metabolism of tumors in the body

Warburg, O., Wind, F., & Negelein, E. (1927) · Journal of General Physiology · doi:10.1085/jgp.8.6.519 · Cited by 4,416 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

The landscape of somatic copy-number alteration across human cancers

Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017 · see citing works

MYC on the Path to Cancer

Dang, C. V. (2012) · Cell · doi:10.1016/j.cell.2012.03.003 · Cited by 3,390 · see citing works

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057 · see citing works

PANTHER: A Library of Protein Families and Subfamilies Indexed by FunctionPreprint

Thomas, P. D., Campbell, M. J., Kejariwal, A., Mi, H., Karlak, B., Daverman, R., Diemer, K., Muruganujan, A., & Narechania, A. (2003) · Genome Research · doi:10.1101/gr.772403 · Cited by 2,912 · see citing works

The UCSC Genome Browser database: update 2011

Fujita, P. A., Rhead, B. L., Zweig, A. S., Hinrichs, A. S., Karolchik, D., Cline, M., Goldman, M. J., Barber, G. P., Clawson, H., Coelho, A., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq963 · Cited by 1,836 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · cited 1× · see citing works

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

Fantin, V. R., St-Pierre, J., & Leder, P. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.04.023 · Cited by 1,635 · see citing works

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591 · see citing works

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., & Dove, W. F. (1992) · Science · doi:10.1126/science.1350108 · Cited by 1,537 · see citing works

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Bonnet, S., Archer, S. L., Allalunis‐Turner, J., Haromy, A., Beaulieu, C., Thompson, R. B., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S. B., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530 · see citing works

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Le, A., Cooper, C. R., Gouw, A. M., Dinavahi, R., Maitra, A., Deck, L. M., Royer, R. E., Jagt, D. L. V., Semenza, G. L., & Dang, C. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914433107 · Cited by 1,528 · see citing works

Recent progress in the biology and physiology of sirtuins

Finkel, T., Deng, C., & Mostoslavsky, R. (2009) · Nature · doi:10.1038/nature08197 · Cited by 1,484 · see citing works

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279 · see citing works

Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs

Guttman, M., Garber, M., Levin, J. Z., Donaghey, J., Robinson, J., Adiconis, X., Fan, L., Koziol, M. J., Gnirke, A., Nusbaum, C., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1633 · Cited by 1,253 · see citing works

Charting histone modifications and the functional organization of mammalian genomes

Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147 · see citing works

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works

The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.041 · Cited by 1,001 · see citing works

MYC as a regulator of ribosome biogenesis and protein synthesis

van Riggelen, J., Yetil, A., & Felsher, D. W. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2819 · Cited by 956 · see citing works

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

Mao, Z., Hine, C., Tian, X., Van Meter, M., Au, M., Vaidya, A., Seluanov, A., & Gorbunova, V. (2011) · Science · doi:10.1126/science.1202723 · Cited by 867 · see citing works

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

Schneider, R., Bannister, A. J., Myers, F. A., Thorne, A. W., Crane‐Robinson, C., & Kouzarides, T. (2003) · Nature Cell Biology · doi:10.1038/ncb1076 · Cited by 792 · see citing works

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782 · see citing works

cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine

Madison, B., Dunbar, L., Qiao, X. T., Braunstein, K., Braunstein, E. M., & Gumucio, D. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204935200 · Cited by 748 · see citing works

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Grandori, C., Gomez-Roman, N., Felton-Edkins, Z. A., Ngouenet, C., Galloway, D. A., Eisenman, R. N., & White, R. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1224 · Cited by 659 · see citing works

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002020 · Cited by 588 · see citing works

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

Kim, H., Vassilopoulos, A., Wang, R.-H., Lahusen, T. J., Xiao, Z., Xu, X., Li, C., Veenstra, T. D., Li, B., Yu, H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.004 · Cited by 536 · see citing works

Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia.

Badea, L., Herlea, V., Dima, S., Dumitraşcu, T., & Popescu, I. (2008) · PubMed · Cited by 531 · see citing works

Untitled work

(2010) · doi:10.1016/j.cmet.2010.06.009 · Cited by 512 · see citing works

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

Arabi, A., Wu, S., Ridderstråle, K., Bierhoff, H., Shiue, C.-N., Fátyol, K., Fahlén, S., Hydbring, P., Söderberg, O., Grummt, I., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1225 · Cited by 471 · see citing works

Over-expression of facilitative glucose transporter genes in human cancer

Yamamoto, T., Seino, Y., Fukumoto, H., Koh, G., Yano, H., Inagaki, N., Yamada, Y., Inoue, K., Manabe, T., & Imura, H. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91263-r · Cited by 465 · see citing works

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

Bell, E. L., Emerling, B. M., Ricoult, S. J. H., & Guarente, L. (2011) · Oncogene · doi:10.1038/onc.2011.37 · Cited by 440 · see citing works

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Barna, M., Pusic, A., Zollo, O., Costa, M. J., Kondrashov, N., Rego, E., Rao, P., & Ruggero, D. (2008) · Nature · doi:10.1038/nature07449 · Cited by 434 · see citing works

Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

Grewal, S., Li, L., Orian, A., Eisenman, R. N., & Edgar, B. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1223 · Cited by 387 · see citing works

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6

Michishita, E., McCord, R. A., Boxer, L. D., Barber, M. F., Hong, T., Gozani, O., & Chua, K. F. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9367 · Cited by 384 · see citing works

Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers.

Younes, M., Lechago, L. V., Somoano, J. R., Mosharaf, M., & Lechago, J. (1996) · PubMed · Cited by 338 · see citing works

Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

Ram, O., Goren, A., Amit, I., Shoresh, N., Yosef, N., Ernst, J., Kellis, M., Gymrek, M., Issner, R., Coyne, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.09.057 · Cited by 331 · see citing works

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

Yang, B., Zwaans, B. M. M., Eckersdorff, M., & Lombard, D. B. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9329 · Cited by 254 · see citing works

Close association of RNA polymerase II and many transcription factors with Pol III genes

Raha, D., Wang, Z., Moqtaderi, Z., Wu, L., Zhong, G., Gerstein, M., Struhl, K., & Snyder, M. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911315106 · Cited by 199 · see citing works

Histone H3 Lysine 56 Acetylation Is Linked to the Core Transcriptional Network in Human Embryonic Stem Cells

Xie, W., Song, C., Young, N. L., Sperling, A. S., Xu, F., Sridharan, R., Conway, A. E., Garcia, B. A., Plath, K., Clark, A. T., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.004 · Cited by 197 · see citing works

Targeted next-generation sequencing of a cancer transcriptome enhances detection of sequence variants and novel fusion transcripts

Levin, J. Z., Berger, M. F., Adiconis, X., Rogov, P., Melnikov, A., Fennell, T., Nusbaum, C., Garraway, L. A., & Gnirke, A. (2009) · Genome biology · doi:10.1186/gb-2009-10-10-r115 · Cited by 193 · see citing works

Crosstalk between c‐Myc and ribosome in ribosomal biogenesis and cancer

Dai, M., & Lu, H. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21895 · Cited by 146 · see citing works

Imaging of mediastinal lymph nodes: CT, MR, and FDG PET.

Boiselle, P. M., Patz, E. F., Vining, D. J., Weissleder, R., Shepard, J. A., & McLoud, T. C. (1998) · Radiographics · doi:10.1148/radiographics.18.5.9747607 · Cited by 129 · see citing works

Tumor Dormancy and MYC Inactivation: Pushing Cancer to the Brink of Normalcy

Shachaf, C. M., & Felsher, D. W. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1172 · Cited by 105 · see citing works

Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

Wu, C.-H., Sahoo, D., Arvanitis, C., Bradon, N., Dill, D. L., & Felsher, D. W. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000090 · Cited by 93 · see citing works

Sirtuin 1 in malignant transformation: Friend or foe?

Fang, Y., & Nicholl, M. B. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.019 · Cited by 93 · see citing works

Sirtuins, Metabolism, and Cancer

Martínez-Pastor, B., & Mostoslavsky, R. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00022 · Cited by 78 · see citing works

Deacetylase Activity Is Required for STAT5-Dependent GM-CSF Functional Activity in Macrophages and Differentiation to Dendritic Cells

Sebastián, C., Serra, M., Yeramian, A., Serrat, N., Lloberas, J., & Celada, A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.5898 · Cited by 54 · see citing works

Microarray meta‐analysis defines global angiogenesis‐related gene expression signatures in human carcinomas

Anders, M., Fehlker, M., Wang, Q., Wissmann, C., Pilarsky, C. P., Kemmner, W., & Höcker, M. R. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20874 · Cited by 18 · see citing works

SIRT1 and other sirtuins in metabolism

Chang, H.-C., & Guarente, L. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.001 · Cited by 1,138 · see citing works

Histone Modifications and CancerPreprint

Audia, J. E., & Campbell, R. M. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019521 · Cited by 1,024 · see citing works

Influence of Metabolism on Epigenetics and Disease

Kaelin, W. G., & McKnight, S. L. (2013) · Cell · doi:10.1016/j.cell.2013.03.004 · Cited by 920 · see citing works

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865 · see citing works

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.93 · Cited by 834 · see citing works

The world of protein acetylation

Drazic, A., Myklebust, L. M., Ree, R., & Arnesen, T. (2016) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2016.06.007 · Cited by 799 · see citing works

Metabolic targets for cancer therapy

Galluzzi, L., Kepp, O., Heiden, M. G. V., & Kroemer, G. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4145 · Cited by 705 · see citing works

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

Feldman, J. L., Baeza, J., & Denu, J. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.c113.511261 · Cited by 637 · see citing works

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

Kim, J., & DeBerardinis, R. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.013 · Cited by 606 · see citing works

What a difference a hydroxyl makes: mutant IDH, (<i>R</i>)-2-hydroxyglutarate, and cancer

Losman, J.-A., & Kaelin, W. G. (2013) · Genes &amp; Development · doi:10.1101/gad.217406.113 · Cited by 570 · see citing works

Meta-hallmarks of aging and cancer

López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works

NAD+ metabolism, stemness, the immune response, and cancer

Navas, L. E., & Carnero, A. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00354-w · Cited by 529 · see citing works

Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes

Etchegaray, J., & Mostoslavsky, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.029 · Cited by 521 · see citing works

The multifaceted functions of sirtuins in cancer

Chalkiadaki, A., & Guarente, L. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3985 · Cited by 501 · see citing works

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

Jiang, H., Zhang, X., Chen, X., Aramsangtienchai, P., Tong, Z., & Lin, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00750 · Cited by 501 · see citing works

Dendritic cell metabolism

Pearce, E. J., & Everts, B. (2014) · Nature reviews. Immunology · doi:10.1038/nri3771 · Cited by 482 · see citing works

Calorie restriction and sirtuins revisited

Guarente, L. (2013) · Genes &amp; Development · doi:10.1101/gad.227439.113 · Cited by 464 · see citing works

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 455 · see citing works

Rod-Derived Cone Viability Factor Promotes Cone Survival by Stimulating Aerobic Glycolysis

Aït-Ali, N., Fridlich, R., Millet-Puel, G., Clérin, E., Delalande, F., Jaillard, C., Blond, F., Perrocheau, L., Reichman, S., Byrne, L. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.023 · Cited by 423 · see citing works

Nuclear DNA damage signalling to mitochondria in ageing

Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.14 · Cited by 387 · see citing works

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

Toiber, D., Erdel, F., Bouazoune, K., Silberman, D. M., Zhong, L., Mulligan, P., Sebastian, C., Cosentino, C., Martinez-Pastor, B., Giacosa, S., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.018 · Cited by 381 · see citing works

Chromatin and beyond: the multitasking roles for SIRT6

Kugel, S., & Mostoslavsky, R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.002 · Cited by 367 · see citing works

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy

Guo, L., Tian, Y., & Zhu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.576946 · Cited by 358 · see citing works

Metabolic Pathways Regulating Colorectal Cancer Initiation and Progression

La Vecchia, S., & Sebastián, C. (2020) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2019.05.018 · Cited by 349 · see citing works

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.4 · Cited by 334 · see citing works

Effects of Oxidative Stress on Mesenchymal Stem Cell Biology

Denu, R. A., & Hematti, P. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2989076 · Cited by 331 · see citing works

Metabolic signatures of cancer cells and stem cells

Intlekofer, A. M., & Finley, L. W. S. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0032-0 · Cited by 322 · see citing works

Dysregulated metabolism contributes to oncogenesis

Hirschey, M. D., DeBerardinis, R. J., Diehl, A. M., Drew, J. E., Frezza, C., Green, M. F., Jones, L. W., Ko, Y. H., Le, A., Lea, M. A., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.10.002 · Cited by 306 · see citing works

SIRT6 suppresses pancreatic cancer through control of Lin28b

Kugel, S., Sebastián, C., Fitamant, J., Ross, K., Saha, S., Jain, E., Gladden, A., Arora, K. S., Kato, Y., Rivera, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.033 · Cited by 251 · see citing works

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs

Choi, J., Lee, S., Clement, K., Mallard, W., Tagliazucchi, G., Lim, H., Choi, I.-Y., Ferrari, F., Tsankov, A. M., Pop, R., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3388 · Cited by 268 · see citing works

Sirtuins: guardians of mammalian healthspan

Giblin, W., Skinner, M. E., & Lombard, D. B. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.04.007 · Cited by 280 · see citing works

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 280 · see citing works

Identification of a cellularly active SIRT6 allosteric activator

Huang, Z., Zhao, J., Deng, W., Chen, Y., Shang, J., Song, K., Zhang, L., Wang, C., Lu, S., Yang, X., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0150-0 · Cited by 277 · see citing works

Sirtuins in Epigenetic Regulation

Jing, H., & Lin, H. (2015) · Chemical Reviews · doi:10.1021/cr500457h · Cited by 271 · see citing works

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

Shaughnessy, D. T., McAllister, K. A., Worth, L., Haugen, A. C., Meyer, J. N., Domann, F. E., Houten, B. V., Mostoslavsky, R., Bultman, S. J., Baccarelli, A., et al. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1408418 · Cited by 267 · see citing works

SIRT6: Novel Mechanisms and Links to Aging and Disease

Tasselli, L., Zheng, W., & Chua, K. F. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.10.002 · Cited by 267 · see citing works

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

Wyngene, L. V., Vandewalle, J., & Libert, C. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708712 · Cited by 264 · see citing works

Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches

Wong, C. C., Qian, Y., & Yu, J. Q. (2017) · Oncogene · doi:10.1038/onc.2016.485 · Cited by 260 · see citing works

Oxidative Stress Signaling to Chromatin in Health and Disease

Kreuz, S., & Fischle, W. (2016) · Epigenomics · doi:10.2217/epi-2016-0002 · Cited by 254 · see citing works

The Substrate Specificity of Sirtuins

Bheda, P., Jing, H., Wolberger, C., & Lin, H. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014537 · Cited by 247 · see citing works

Sorting out functions of sirtuins in cancer

Roth, M., & Chen, W. (2013) · Oncogene · doi:10.1038/onc.2013.120 · Cited by 239 · see citing works

SIRT6, a Mammalian Deacylase with Multitasking Abilities

Chang, A. R., Ferrer, C. M., & Mostoslavsky, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00030.2018 · Cited by 236 · see citing works

The Glycolytic Switch in Tumors: How Many Players Are Involved?

Yu, L., Chen, X., Sun, X., Wang, L., & Chen, S. (2017) · Journal of Cancer · doi:10.7150/jca.21125 · Cited by 233 · see citing works

The importance of NAMPT / NAD / SIRT1 in the systemic regulation of metabolism and ageing

Imai, S., & Yoshino, J. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12171 · Cited by 232 · see citing works

Site-specific mapping and quantification of protein S-sulphenylation in cells

Yang, J. H., Gupta, V., Carroll, K. S., & Liebler, D. C. (2014) · Nature Communications · doi:10.1038/ncomms5776 · Cited by 232 · see citing works

From Sirtuin Biology to Human Diseases: An Update

Sebastián, C., Satterstrom, F. K., Haigis, M. C., & Mostoslavsky, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.402768 · Cited by 228 · see citing works

Repression of RNA Polymerase I upon Stress Is Caused by Inhibition of RNA-Dependent Deacetylation of PAF53 by SIRT7

Chen, S., Seiler, J., Santiago-Reichelt, M., Felbel, K., Grummt, I., & Voit, R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.010 · Cited by 224 · see citing works

Small-Molecule Allosteric Activators of Sirtuins

Sinclair, D. A., & Guarente, L. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134657 · Cited by 223 · see citing works

Sirtuins in glucose and lipid metabolism

Ye, X., Li, M., Hou, T., Gao, T., Zhu, W., & Yang, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.12157 · Cited by 215 · see citing works

Chromatin signatures of cancerPreprint

Morgan, M. A., & Shilatifard, A. (2015) · Genes & Development · doi:10.1101/gad.255182.114 · Cited by 214 · see citing works

SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence

Tasselli, L., Xi, Y., Zheng, W., Tennen, R. I., Odrowaz, Z., Simeoni, F., Li, W., & Chua, K. F. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3202 · Cited by 213 · see citing works

Restoration of energy homeostasis by SIRT6 extends healthy lifespan

Roichman, A., Elhanati, S., Aon, M. A., Abramovich, I., Francesco, A. D., Shahar, Y., Avivi, M. Y., Shurgi, M., Rubinstein, A., Wiesner, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23545-7 · Cited by 210 · see citing works

USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

Lin, Z., Yang, H., Tan, C., Li, J., Liu, Z., Quan, Q., Kong, S., Ye, J., Gao, B., & Fang, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.029 · Cited by 206 · see citing works

Crosstalk between metabolic reprogramming and epigenetics in cancer: updates on mechanisms and therapeutic opportunities

Ge, T., Gu, X., Jia, R., Ge, S., Chai, P., Zhuang, A., & Fan, X. (2022) · 癌症：英文版 · doi:10.1002/cac2.12374 · Cited by 206 · see citing works

Sirtuins in metabolism, DNA repair and cancer

Mei, Z., Zhang, X., Yi, J., Huang, J., He, J., & Tao, Y. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0461-5 · Cited by 191 · see citing works

The role of sirtuins in aging and age-related diseases

Wątroba, M., & Szukiewicz, D. (2015) · Advances in Medical Sciences · doi:10.1016/j.advms.2015.09.003 · Cited by 185 · see citing works

A Tale of Two Glutaminases: Homologous Enzymes with Distinct Roles in Tumorigenesis

Katt, W. P., Lukey, M. J., & Cerione, R. A. (2017) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0190 · Cited by 179 · see citing works

Emerging roles of SIRT6 in human diseases and its modulators

Liu, G., Chen, H., Liu, H., Zhang, W., & Zhou, J. (2020) · Medicinal Research Reviews · doi:10.1002/med.21753 · Cited by 177 · see citing works

Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

Lu, S., He, X., Ni, D., & Zhang, J. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01749 · Cited by 176 · see citing works

Melatonin and sirtuins: A “not-so unexpected” relationship

Mayo, J. C., Sainz, R. M., González Menéndez, P., Cepas, V., Tan, D., & Reiter, R. J. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12391 · Cited by 175 · see citing works

Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

Zhao, L., Cao, J., Hu, K., He, X., Dou, Y., Tong, T., & Han, L. (2020) · Aging and Disease · doi:10.14336/ad.2019.0820 · Cited by 174 · see citing works

Sirtuin Inhibitors as Anticancer Agents

Hu, J., Jing, H., & Lin, H. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.44 · Cited by 168 · see citing works

The emerging and diverse roles of sirtuins in cancer: a clinical perspective

Chen, W., Yuan, H., & Su, L. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s37750 · Cited by 163 · see citing works

Neuroprotective Functions for the Histone Deacetylase SIRT6

Kaluski, S., Portillo, M., Besnard, A., Stein, D., Einav, M., Zhong, L., Ueberham, U., Arendt, T., Mostoslavsky, R., Sahay, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.008 · Cited by 163 · see citing works

Sirtuin-6–Dependent Genetic And Epigenetic Alterations Are Associated With Poor Clinical Outcome in Hepatocellular Carcinoma Patients

Marquardt, J. U., Fischer, K., Baus, K., Kashyap, A., Ma, S., Krupp, M., Linke, M., Teufel, A., Zechner, U., Strand, D. J., et al. (2013) · Hepatology · doi:10.1002/hep.26413 · Cited by 161 · see citing works

SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases

Guo, Z., Li, P., Ge, J., & Li, H. (2022) · Aging and Disease · doi:10.14336/ad.2022.0413 · Cited by 160 · see citing works

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine

Etchegaray, J., Chávez, L., Huang, Y., Ross, K. N., Choi, J., Martínez-Pastor, B., Walsh, R. M., Sommer, C., Lienhard, M., Gladden, A. D., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3147 · Cited by 155 · see citing works

Multiple Regulatory Layers of SREBP1/2 by SIRT6

Elhanati, S., Kanfi, Y., Varvak, A., Roichman, A., Carmel-Gross, I., Barth, S., Gibor, G., & Cohen, H. Y. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.006 · Cited by 155 · see citing works

SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions

Bhardwaj, A., & Das, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520045113 · Cited by 154 · see citing works

Natural polyphenols as sirtuin 6 modulators

Rahnasto‐Rilla, M., Tyni, J., Huovinen, M., Jarho, E. M., Kulikowicz, T., Ravichandran, S., Bohr, V. A., Ferrucci, L., Lahtela-Kakkonen, M. K., & Moaddel, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-22388-5 · Cited by 149 · see citing works

USP48 Is Upregulated by Mettl14 to Attenuate Hepatocellular Carcinoma via Regulating SIRT6 Stabilization

Du, L., Yang, L., Kang, M., Feng, M., Ren, Y., Dai, H., Wang, Y., Wang, Y., & Tang, B. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-4163 · Cited by 145 · see citing works

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’

Huang, J., Xie, Y., Sun, X., Zeh, H. J., Kang, R., Lotze, M. T., & Tang, D. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.004 · Cited by 144 · see citing works

“Cell Membrane Theory of Senescence” and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications

Das, U. N. (2021) · Biomolecules · doi:10.3390/biom11020241 · Cited by 142 · see citing works

The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

Roos, W. P., & Krumm, A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw922 · Cited by 140 · see citing works

SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

Greene, K. S., Lukey, M. J., Wang, X., Blank, B. S., Druso, J. E., Lin, M.-C. J., Stalnecker, C. A., Zhang, C., Abril, Y. L. N., Erickson, J. W., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911954116 · Cited by 138 · see citing works

SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling

Wang, H., Diao, D., Shi, Z., Zhu, X., Gao, Y., Gao, S., Liu, X., Wu, Y., Rudolph, K. L., Liu, G., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.03.005 · Cited by 137 · see citing works

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc

Li, Y., Wang, Z., Shi, H., Li, H., Li, L., Fang, R., Cai, X., Liu, B., Zhang, X., & Ye, L. (2016) · Cancer Research · doi:10.1158/0008-5472.can-14-3607 · Cited by 136 · see citing works

A miR‐34a‐SIRT6 axis in the squamous cell differentiation network

Lefort, K., Brooks, Y., Ostano, P., Cario, M., Calpini, V., Guinea‐Viniegra, J., Albinger‐Hegyi, A., Hoetzenecker, W., Kolfschoten, I., Wagner, E. F., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.156 · Cited by 135 · see citing works

SIRT6 exhibits nucleosome-dependent deacetylase activity

Gil, R., Barth, S., Kanfi, Y., & Cohen, H. Y. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt642 · Cited by 133 · see citing works

Targeted inhibition of SIRT6 via engineered exosomes impairs tumorigenesis and metastasis in prostate cancer

Han, Q., Xie, Q. R., Li, F., Cheng, Y., Wu, T., Zhang, Y., Lu, X., Wong, A. S. T., Sha, J., & Xia, W. (2021) · Theranostics · doi:10.7150/thno.53886 · Cited by 134 · see citing works

Circadian clocks, epigenetics, and cancer

Masri, S., Kinouchi, K., & Sassone‐Corsi, P. (2014) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000153 · Cited by 133 · see citing works

Caloric restriction and cancer: molecular mechanisms and clinical implications

Meynet, O., & Ricci, J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.001 · Cited by 133 · see citing works

Sirtuins, metabolism, and DNA repair

Choi, J.-E., & Mostoslavsky, R. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.05.005 · Cited by 132 · see citing works

Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair

Ghosh, S., Liu, B., Wang, Y., Hao, Q., & Zhou, Z. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.006 · Cited by 129 · see citing works

The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells

Sharma, A. S., Diecke, S., Zhang, W. Y., Lan, F., He, C., Mordwinkin, N. M., Chua, K. F., & Wu, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.405928 · Cited by 128 · see citing works

Nuclear metabolism and the regulation of the epigenome

Boon, R., da Silveira, G. G., & Mostoslavsky, R. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00285-4 · Cited by 126 · see citing works

Epigenetic crosstalk between hypoxia and tumor driven by HIF regulation

Li, T., Mao, C., Wang, X., Shi, Y., & Tao, Y. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01733-5 · Cited by 125 · see citing works

Sirtuins in stress response: guardians of the genome

Bosch‐Presegué, L., & Vaquero, A. (2013) · Oncogene · doi:10.1038/onc.2013.344 · Cited by 124 · see citing works

An Epigenetic Role of Mitochondria in Cancer

Liu, Y., Chen, C., Wang, X., Sun, Y., Zhang, J., Chen, J., & Shi, Y. (2022) · Cells · doi:10.3390/cells11162518 · Cited by 125 · see citing works

Epigenetics in ovarian cancer: premise, properties, and perspectives

Yang, Q., Yang, Y., Zhou, N., Tang, K., Lau, W. B., Lau, B., Wang, W., Xu, L., Yang, Z., Huang, S., et al. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0855-4 · Cited by 122 · see citing works

Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets

Miranda‐Gonçalves, V., Lameirinhas, A., Henrique, R., & Jerónimo, C. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00427 · Cited by 122 · see citing works

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells

Cea, M., Cagnetta, A., Adamia, S., Acharya, C., Tai, Y., Fulciniti, M., Ohguchi, H., Munshi, A., Acharya, P. C., Bhasin, M., et al. (2015) · Blood · doi:10.1182/blood-2015-06-649970 · Cited by 121 · see citing works

Discovery of Novel and Selective SIRT6 Inhibitors

Parenti, M. D., Grozio, A., Bauer, I., Galeno, L., Damonte, P., Millo, E., Sociali, G., Franceschi, C., Ballestrero, A., Bruzzone, S., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500487d · Cited by 121 · see citing works

SIRT1 and SIRT6: The role in aging-related diseases

You, Y., & Liang, W. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166815 · Cited by 120 · see citing works

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

Xu, Z., Zhang, L., Zhang, W., Du, M., Zhang, H., Jiang, Y., Xu, X., Meter, M. V., Seluanov, A., Gorbunova, V. A., et al. (2015) · Cell Cycle · doi:10.4161/15384101.2014.980641 · Cited by 118 · see citing works

Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6

Liu, R., Liu, H., Ha, Y., Tilton, R. G., & Zhang, W. (2014) · BioMed Research International · doi:10.1155/2014/902842 · Cited by 118 · see citing works

Epigenetic regulation in cancer

Gu, M., Ren, B., Fang, Y., Ren, J., Liu, X., Wang, X., Zhou, F., Xiao, R., Luo, X., You, L., et al. (2024) · MedComm · doi:10.1002/mco2.495 · Cited by 119 · see citing works

Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

Liu, Y., Xie, Q. R., Wang, B., Shao, J., Zhang, T., Liu, T., Huang, G., & Xia, W. (2013) · Protein & Cell · doi:10.1007/s13238-013-3054-5 · Cited by 118 · see citing works

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

Cohen, A. J., Saiakhova, A., Corradin, O., Luppino, J. M., Lovrenert, K., Bartels, C. F., Morrow, J. J., Mack, S. C., Dhillon, G. K., Beard, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms14400 · Cited by 116 · see citing works

A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD + -Dependent Enzymes

Yuen, L. H., Dana, S., Liu, Y., Bloom, S. I., Thorsell, A. G., Neri, D., Donato, A. J., Kireev, D., Schuler, H., & Franzini, R. M. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b08039 · Cited by 116 · see citing works

The histone deactylase SIRT6 is a novel tumor suppressor that regulates cancer metabolism.

Sebastián Muñoz, C. (2013) · RECERCAT (Consorci de Serveis Universitaris de Catalunya)

Metabolic Regulation by the SIRT6 Deacetylase Prevents Tumorigenesis

(2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2012-227

Abstract SY20-01: Linking epigenetics, metabolism, and cancer: Lessons from SIRT6

Mostoslavsky, R. (2019) · Cancer Research · doi:10.1158/1538-7445.am2019-sy20-01

The histone deacetylase SIRT6, a critical modulator of metabolism and tumorigenesis

Sebastián, C., Zhong, L., Silberman, M., Toiber, D., Martinez, B., Etchegaray, J., Cosentino, C., Giacosa, S., & Mostoslavsky, R. (2012) · BMC Proceedings · doi:10.1186/1753-6561-6-s3-o17 · Cited by 3 · see citing works

Linking Epigenetics, Metabolism and Cancer: Lessons From SIRT6

Mostoslavsky, R. (2020) · Innovation in Aging · doi:10.1093/geroni/igaa057.2651