Farese, Robert V.

Cellular Fatty Acid Metabolism and Cancer

Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 2,123

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 2,075

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology

Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

Cited by 1,216

Thematic review series: Glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

Yen, C.-L. E., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V. (2008) · Journal of Lipid Research

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 1,105

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E., & Charo, I. F. (1997) · Journal of Clinical Investigation

Chemokine receptors and signalingAtherosclerosis and Cardiovascular Diseases

Cited by 1,096

Cloning of DGAT2, a Second Mammalian Diacylglycerol Acyltransferase, and Related Family Members

Cases, S., Stone, S. J., Zhou, P., Yen, E., Tow, B., Lardizabal, K. D., Voelker, T., & Farese, R. V. (2001) · Journal of Biological Chemistry

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 818

A guide to analysis of mouse energy metabolism

Tschöp, M. H., Speakman, J. R., Arch, J. R. S., Auwerx, J., Brüning, J. C., Chan, L., Eckel, R. H., Farese, R. V., Galgani, J. E., Hambly, C., et al. (2012) · Nature Methods

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 813

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

Wilfling, F., Wang, H., Haas, J. T., Krahmer, N., Gould, T. J., Uchida, A., Cheng, J.-X., Graham, M., Christiano, R., Fröhlich, F., et al. (2013) · Developmental Cell

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 806

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

Hirschey, M. D., Shimazu, T., Jing, E., Grueter, C. A., Collins, A. M., Aouizerat, B., Stančáková, A., Goetzman, E., Lam, M. M., Schwer, B., et al. (2011) · Molecular Cell

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 787

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell

Neuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

Cited by 729

The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria

Stone, S. J., Levin, M. C., Zhou, P., Han, J., Walther, T. C., & Farese, R. V. (2009) · Journal of Biological Chemistry

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 390

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., et al. (2019) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 285

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

Piccolis, M., Bond, L. M., Kampmann, M., Pulimeno, P., Chitraju, C., Jayson, C. B. K., Vaites, L. P., Boland, S., Lai, Z. W., Gabriel, K. R., et al. (2019) · Molecular Cell

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 269

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Minami, S. S., Min, S.-W., Krabbe, G., Wang, C., Zhou, Y., Asgarov, R., Li, Y., Martens, L. H., Elia, L. P., Ward, M. E., et al. (2014) · Nature Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 237

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes

Chitraju, C., Walther, T. C., & Farese, R. V. (2019) · Journal of Lipid Research

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 206

Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism

Koliwad, S. K., Kuo, T., Shipp, L. E., Gray, N. E., Backhed, F., So, A. Y.-L., Farese, R. V., & Wang, J.-C. (2009) · Journal of Biological Chemistry

Lipid metabolism and disordersLipid metabolism and biosynthesis

Cited by 164

Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations

Zhang, Z., Almeida, S., Lu, Y., Nishimura, A. L., Peng, L., Sun, D., Wu, B., Karydas, A. M., Tartaglia, M. C., Fong, J. C., et al. (2013) · PLoS ONE

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 142

Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects

Almeida, S., Zhang, Z., Coppola, G., Mao, W., Futai, K., Karydas, A., Geschwind, M. D., Tartaglia, M. C., Gao, F., Gianni, D., et al. (2012) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 140

Partitioning of MLX-family transcription factors to lipid droplets regulates metabolic gene expression

Mejhert, N., Kuruvilla, L., Gabriel, K. R., Elliott, S. D., Guie, M.-A., Wang, H., Lai, Z. W., Lane, E. A., Christiano, R., Danial, N. N., et al. (2020) · Molecular Cell

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 121

Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme

Sui, X., Wang, K., Gluchowski, N. L., Elliott, S. D., Liao, M., Walther, T. C., & Farese, R. V. (2020) · Nature

Lipid metabolism and biosynthesisLipid metabolism and disorders

Cited by 120

Seipin forms a flexible cage at lipid droplet formation sites

Arlt, H., Sui, X., Folger, B., Adams, C., Chen, X., Remme, R., Hamprecht, F. A., DiMaio, F., Liao, M., Goodman, J. M., et al. (2022) · Nature Structural & Molecular Biology

Lipid metabolism and biosynthesisProtein Structure and Dynamics

Cited by 107

Seipin forms a flexible cage at lipid droplet formation sites

Arlt, H., Sui, X., Folger, B., Adams, C., Chen, X., Remme, R., Hamprecht, F. A., DiMaio, F., Liao, M., Goodman, J. M., et al. (2021) · Nature Structural & Molecular Biology

Lipid metabolism and biosynthesisProtein Structure and Dynamics

Cited by 107

Identification of two pathways mediating protein targeting from ER to lipid droplets

Song, J., Mizrak, A., Lee, C.-W., Cicconet, M., Lai, Z. W., Tang, W.-C., Lu, C.-H., Mohr, S. E., Farese, R. V., & Walther, T. C. (2022) · Nature Cell Biology

Cellular transport and secretionLipid metabolism and biosynthesis

Cited by 106

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Boland, S., Swarup, S., Ambaw, Y. A., Malia, P. C., Richards, R. C., Fischer, A. W., Singh, S., Aggarwal, G., Spina, S., Nana, A. L., et al. (2022) · Nature Communications

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 97