Cellular Fatty Acid Metabolism and Cancer
Open accessAbstract
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation.
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ACLY is a key enzyme in the shift from the TCA cycle to lipid formation and has been shown to cause lipid droplet accumulation.
“For example, expression of ACLY, a key enzyme in the shift from the TCA cycle to lipid formation that has been shown to cause lipid droplet accumulation42, is significantly higher in LDAM than in microglia without lipid droplets.”
From Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain (2020) · cites this paper as [42]
The ACLY subsection of “Blocking Fatty Acid Synthesis” says ACLY links glucose metabolism to fatty-acid synthesis and that knocking it down reduces conversion of glucose to lipid. The “Diverting Fatty Acids to Storage” subsection discusses lipid droplets, but does not say ACLY causes their accumulation. Page numbers are unavailable in our copy. (LLM, conf=0.87)
Experimental — accuracy not yet measuredFatty acid synthesis is an anabolic process that uses cytosolic citrate to produce acetyl-CoA.
“Fatty acid synthesis is an anabolic process that uses cytosolic citrate to produce acetyl-CoA73.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [73]
Mitochondrial citrate is transported across the inner mitochondrial membrane via CIC or SLC25A1 to support fatty acid synthesis for tumor progression in hypoxia.
“Next, mitochondrial citrate is transported across the inner mitochondrial membrane via a citrate carrier (CIC or SLC25A1) to support fatty acid synthesis for tumor progression in hypoxia73 (Fig. 4).”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [73]
PHD3 is suppressed in cancers that rely on FAO, such as AML and prostate cancer, and elevated in cancers that rely on FAS such as breast and non-small-lung-cell cancer.
“PHD3 is suppressed in cancers that rely on FAO, such as AML and prostate cancer, and elevated in cancers that rely on FAS such as breast and non-small-lung-cell cancer.55–57”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [56]
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- Authors
- Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V.
- Affiliations
- University of California, San Francisco (US)
- Cancer Research UK (GB)
- University of Graz (AT)
- Yale University (US)
- Corresponding author
- Farese, Robert V.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 18
- Issue
- 2
- Pages
- 153-161
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3742569
- OpenAlex
- W1980568044
- Cited by
- 2,123
- References
- 82
- Citations by year
- 2026: 118 · 2025: 221 · 2024: 228 · 2023: 221 · 2022: 266 · 2021: 204 · 2020: 193 · 2019: 177 · 2018: 139 · 2017: 122 · 2016: 115 · 2015: 72 · 2014: 41 · 2013: 1
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM099844, R01GM097194)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056084, P30DK063720, P30DK026743)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- fatty acid metabolism, cancer metabolism, lipid metabolism, tumor cell proliferation, fatty acid availability, membrane lipid synthesis
- MeSH terms
- Energy Metabolism, Fatty Acids, Humans, Neoplasms, Cell Proliferation, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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