Loo, Tze Mun

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature

Gut microbiota and healthTelomeres, Telomerase, and Senescence

Cited by 2,219

Gut microbiota promotes obesity-associated liver cancer through pge2-mediated suppression of antitumor immunity.

Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery

Gut microbiota and healthHepatocellular Carcinoma Treatment and Prognosis

Cited by 478

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G. N., et al. (2018) · Nature Communications

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 350

Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer

Loo, T. M., Miyata, K., Tanaka, Y., & Takahashi, A. (2020) · Cancer Science

Telomeres, Telomerase, and Senescenceinterferon and immune responses

Cited by 232

A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells

Wakita, M., Takahashi, A., Sano, O., Loo, T. M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, S., Ohtani, N., et al. (2020) · Nature Communications

Telomeres, Telomerase, and SenescenceProtein Degradation and Inhibitors

Cited by 206

Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma

Yamagishi, R., Kamachi, F., Nakamura, M., Yamazaki, S., Kamiya, T., Takasugi, M., Cheng, Y., Nonaka, Y., Yukawa-Muto, Y., Thuy, L. T. T., et al. (2022) · Science Immunology

IL-33, ST2, and ILC PathwaysInflammasome and immune disorders

Cited by 173

Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer

Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T. M., Okada, R., Yang, L., Nakadai, T., Maruyama, R., Fujii, R., et al. (2021) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 74

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Sugawara, S., Okada, R., Loo, T. M., Tanaka, H., Miyata, K., Chiba, M., Kawasaki, H., Katoh, K., Kaji, S., Maezawa, Y., et al. (2022) · Communications Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 23