Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma
Open accessAbstract
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although the mechanisms of SASP factor induction have been intensively studied, the release mechanism and how SASP factors influence tumorigenesis in the biological context remain unclear. In this study, using a mouse model of obesity-induced hepatocellular carcinoma (HCC), we identified the release mechanism of SASP factors, which include interleukin-1β (IL-1β)– and IL-1β–dependent IL-33, from senescent hepatic stellate cells (HSCs) via gasdermin D (GSDMD) amino-terminal–mediated pore. We found that IL-33 was highly induced in senescent HSCs in an IL-1β–dependent manner in the tumor microenvironment. The release of both IL-33 and IL-1β was triggered by lipoteichoic acid (LTA), a cell wall component of gut microbiota that was transferred and accumulated in the liver tissue of high-fat diet–fed mice, and the release of these factors was mediated through cell membrane pores formed by the GSDMD amino terminus, which was cleaved by LTA-induced caspase-11. We demonstrated that IL-33 release from HSCs promoted HCC development via the activation of ST2-positive T reg cells in the liver tumor microenvironment. The accumulation of GSDMD amino terminus was also detected in HSCs from human NASH-associated HCC patients, suggesting that similar mechanism could be involved in a certain type of human HCC. These results uncover a release mechanism for SASP factors from sensitized senescent HSCs in the tumor microenvironment, thereby facilitating obesity-associated HCC progression. Furthermore, our findings highlight the therapeutic potential of inhibitors of GSDMD-mediated pore formation for HCC treatment.
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p21 increased with age in a subset of terminally differentiated myofibers, which also displayed other senescence-associated markers such as TAF, SADS, nuclear loss of LMNB1, HMGB1, and a unique SASP.
“Interestingly, p21 increased with age in a subset of terminally differentiated myofibers, which also displayed other senescence-associated markers such as TAF, SADS, nuclear loss of LMNB1, HMGB1, and a unique SASP88,89.”
From Guidelines for minimal information on cellular senescence experimentation in vivo (2024) · cites this paper as [89]
The section ‘IL-33 from senescent HSCs promotes obesity-associated HCC development’ reports more p21-positive hepatic stellate cells in high-fat-diet mouse livers, alongside SASP factors. It does not report an age-related increase in p21 in terminally differentiated myofibers or the listed markers in those cells (searched: myofibers, skeletal muscle, TAF, SADS, and HMGB1). (LLM, conf=0.78)
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Cites
The blockade of immune checkpoints in cancer immunotherapy
Pardoll, D. M. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3239 · Cited by 13,838 · see citing works
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659 · see citing works
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works
Cellular Senescence: Defining a Path Forward
Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · see citing works
Self-citationCTLA-4 Control over Foxp3 <sup>+</sup> Regulatory T Cell Function
Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956 · see citing works
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Yoshimoto, S., Loo, T. M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., et al. (2013) · Nature · doi:10.1038/nature12347 · Cited by 2,219 · see citing works
Self-citationThe gasdermins, a protein family executing cell death and inflammation
Broz, P., Pelegrín, P., & Shao, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0228-2 · Cited by 1,641 · see citing works
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Kang, T.-W., Yevsa, T., Woller, N., Hoenicke, L., Wuestefeld, T., Dauch, D., Hohmeyer, A., Gereke, M., Rudalska, R., Potapova, A., et al. (2011) · Nature · doi:10.1038/nature10599 · Cited by 1,621 · see citing works
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586 · see citing works
Self-citationMederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Dou, Z., Ghosh, K., Vizioli, M. G., Zhu, J., Sen, P., Wangensteen, K. J., Simithy, J., Lan, Y., Lin, Y., Zhou, Z., et al. (2017) · Nature · doi:10.1038/nature24050 · Cited by 1,335 · see citing works
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Li, T., & Chen, Z. J. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180139 · Cited by 1,293 · see citing works
Laberge, R.-M., Sun, Y., Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3195 · Cited by 1,160 · see citing works
Interleukin-33 in health and disease
Liew, F. Y., Girard, J., & Turnquist, H. R. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.95 · Cited by 1,157 · see citing works
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0669-6 · Cited by 1,145 · see citing works
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Evavold, C. L., Ruan, J., Tan, Y., Xia, S., Wu, H., & Kagan, J. C. (2018) · Immunity · doi:10.1016/j.immuni.2017.11.013 · Cited by 1,115 · see citing works
Inflammasome Complexes: Emerging Mechanisms and Effector Functions
Rathinam, V. A. K., & Fitzgerald, K. A. (2016) · Cell · doi:10.1016/j.cell.2016.03.046 · Cited by 1,109 · see citing works
The immunology of hepatocellular carcinoma
Ringelhan, M., Pfister, D., O’Connor, T., Pikarsky, E., & Heikenwalder, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0044-z · Cited by 1,076 · see citing works
Lamin B1 loss is a senescence-associated biomarker
Freund, A., Laberge, R.-M., Demaria, M., & Campisi, J. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-10-0884 · Cited by 1,046 · see citing works
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
Brestoff, J. R., Kim, B. S., Saenz, S. A., Stine, R. R., Monticelli, L. A., Sonnenberg, G. F., Thome, J. J., Farber, D. L., Lutfy, K., Seale, P., et al. (2015) · Nature · doi:10.1038/nature14115 · Cited by 968 · see citing works
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works
Interleukin‐33 ( IL ‐33): A nuclear cytokine from the IL ‐1 family
Cayrol, C., & Girard, J. (2017) · Immunological Reviews · doi:10.1111/imr.12619 · Cited by 895 · see citing works
Unmasking senescence: context-dependent effects of SASP in cancer
Faget, D. V., Ren, Q., & Stewart, S. A. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0156-2 · Cited by 863 · see citing works
Non-Cell-Autonomous Tumor Suppression by p53
Lujambio, A., Akkari, L., Simon, J., Grace, D., Tschaharganeh, D. F., Bolden, J. E., Zhao, Z., Thapar, V., Joyce, J. A., Krizhanovsky, V., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.020 · Cited by 766 · cited 1× · see citing works
“On the other hand, another report showed that the suppression of cellular senescence in HSCs by crossing p53flox/flox and GFAP (glial fibrillary acidic protein)–Cre mice exhibited subtle increase of HCC development (56), suggesting a tumor-suppressive role of SASP in HSCs.”
BackgroundDevelopment and Maintenance of Regulatory T cells
Ohkura, N., Kitagawa, Y., & Sakaguchi, S. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.002 · Cited by 728 · see citing works
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy
Cayrol, C., & Girard, J. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.09.004 · Cited by 700 · see citing works
IL-33 is a crucial amplifier of innate rather than acquired immunity
Oboki, K., Ohno, T., Kajiwara, N., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Matsumoto, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003059107 · Cited by 655 · see citing works
Self-citationHorai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M., & Iwakura, Y. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1463 · Cited by 611 · see citing works
Self-citationSchönbeck, U., Mach, F., & Libby, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.7.3340 · Cited by 605 · see citing works
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G
Lefrançais, E., Roga, S., Gautier, V., de Peredo, A. G., Monsarrat, B., Girard, J., & Cayrol, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115884109 · Cited by 598 · see citing works
Vasanthakumar, A., Moro, K., Xin, A., Liao, Y., Gloury, R., Kawamoto, S., Fagarasan, S., Mielke, L. A., Afshar‐Sterle, S., Masters, S. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3085 · Cited by 556 · see citing works
Self-citationHigh-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers
Mederacke, I., Dapito, D. H., Affò, S., Uchinami, H., & Schwabe, R. F. (2015) · Nature Protocols · doi:10.1038/nprot.2015.017 · Cited by 541 · see citing works
The plasticity and stability of regulatory T cells
Sakaguchi, S., Vignali, D. A. A., Rudensky, A. Y., Niec, R. E., & Waldmann, H. (2013) · Nature reviews. Immunology · doi:10.1038/nri3464 · Cited by 529 · see citing works
Self-citationLoo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0932 · Cited by 478 · see citing works
Self-citationDegradation of Interleukin 1β by Matrix Metalloproteinases
Itô, A., Mukaiyama, A., Itoh, Y., Nagase, H., Thøgersen, I. B., Enghild, J. J., Sasaguri, Y., & Mori, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.14657 · Cited by 390 · see citing works
Lefrançais, E., Duval, A., Mirey, E., Roga, S., Espinosa, É., Cayrol, C., & Girard, J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410700111 · Cited by 385 · see citing works
Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G. N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03555-8 · Cited by 350 · see citing works
Self-citationAdam, M., Potter, A. S., & Potter, S. S. (2017) · Development · doi:10.1242/dev.151142 · Cited by 343 · see citing works
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
Moral, J. A., Leung, J., Rojas, L. A., Ruan, J. J., Zhao, J. N., Sethna, Z. M., Ramnarain, A., Gasmi, B., Gururajan, M., Redmond, D., et al. (2020) · Nature · doi:10.1038/s41586-020-2015-4 · Cited by 343 · see citing works
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works
Gasdermins and their role in immunity and inflammation
Ørning, P., Lien, E., & Fitzgerald, K. A. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190545 · Cited by 273 · see citing works
Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression
Taniguchi, S., Elhance, A., Duzer, A. V., Kumar, S., Leitenberger, J. J., & Oshimori, N. (2020) · Science · doi:10.1126/science.aay1813 · Cited by 258 · see citing works
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
Eissmann, M. F., Dijkstra, C., Jarnicki, A., Phesse, T. J., Brunnberg, J., Poh, A. R., Etemadi, N., Tsantikos, E., Thiem, S., Huntington, N. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10676-1 · Cited by 232 · see citing works
Young, A. R. J., & Narita, M. (2009) · The EMBO Reports · doi:10.1038/embor.2009.22 · Cited by 214 · see citing works
Boeck, A. D., Ahn, B. Y., D’Mello, C., Lun, X. Q., Menon, S. V., Alshehri, M. M., Szulzewsky, F., Shen, Y., Khan, L., Dang, N. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18569-4 · Cited by 181 · see citing works
IL-33 in T Cell Differentiation, Function, and Immune Homeostasis
Peine, C., Marek, R. M., & Löhning, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.03.007 · Cited by 180 · see citing works
Myocardial pressure overload induces systemic inflammation through endothelial cell IL-33
Chen, W., Hong, J., Gannon, J., Kakkar, R. K., & Lee, R. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424236112 · Cited by 160 · see citing works
Self-citationThe IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer
Pastille, E., Wasmer, M.-H., Adamczyk, A., Vu, V. P., Mager, L. F., Phuong, N. N. T., Palmieri, V., Simillion, C., Hansen, W., Kasper, S., et al. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0176-y · Cited by 151 · see citing works
Scott, I. C., Majithiya, J. B., Sandén, C., Thornton, P., Sanders, P. N., Moore, T., Guscott, M. A., Corkill, D. J., Erjefalt, J. S., & Cohen, E. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-21589-2 · Cited by 115 · see citing works
Ohno, T., Morita, H., Arae, K., Matsumoto, K., & Nakae, S. (2012) · Allergy · doi:10.1111/all.12004 · Cited by 104 · see citing works
Self-citationAmeri, A. H., Tuchayi, S. M., Zaalberg, A., Park, J. H., Ngo, K. H., Li, T., Lopez, E., Colonna, M., Lee, R. T., Mino-Kenudson, M. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815016116 · Cited by 85 · see citing works
Disulfiram Treatment Normalizes Body Weight in Obese Mice
Bernier, M., Mitchell, S. J., Wahl, D., Diaz, A., Singh, A., Seo, W., Wang, M., Ali, A., Kaiser, T., Price, N. L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.019 · Cited by 85 · see citing works
PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions
Ercolano, G., Gomez‐Cadena, A., Dumauthioz, N., Vanoni, G., Kreutzfeldt, M., Wyss, T., Michalik, L., Loyon, R., Ianaro, A., Ho, P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22764-2 · Cited by 85 · see citing works
IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development
Li, A., Herbst, R. H., Canner, D. A., Schenkel, J. M., Smith, O. C. G., Kim, J. Y., Hillman, M., Bhutkar, A. J., Cuoco, M. S., Rappazzo, C. G., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.120 · Cited by 81 · see citing works
Wen, Y., Lin, H., Li, H., Zhao, Y., Lui, V. W. Y., Chen, L., Wu, X., Sun, W., & Wen, W. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2265-2 · Cited by 66 · see citing works
Jin, Z., Lei, L., Lin, D., Liu, Y., Song, Y., Gong, H., Zhu, Y., Mei, Y., Hu, B., Wu, Y., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800627 · Cited by 61 · see citing works
Bali, K. K., & Kuner, R. (2017) · Pain · doi:10.1097/j.pain.0000000000001032 · Cited by 34 · see citing works
Wang, W., Wu, J., Ji, M., & Wu, C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02661-w · Cited by 30 · see citing works
Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells
Steinmann, S., Schoedsack, M., Heinrich, F., Breda, P., Ochel, A., Tiegs, G., & Neumann, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-57985-w · Cited by 26 · see citing works
Ruan, L., Osawa, M., Hosoda, N., Imai, S., Machiyama, A., Katada, T., Hoshino, S.-I., & Shimada, I. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138867 · Cited by 25 · see citing works
Zhao, R., Yu, Z., Li, M., & Zhou, Y. (2019) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2019.07.008 · Cited by 15 · see citing works
Flagged first, then by citations
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Wang, B., Han, J., Elisseeff, J. H., & Demaria, M. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00727-x · Cited by 948 · see citing works
Guidelines for minimal information on cellular senescence experimentation in vivo
Ogrodnik, M., Carlos Acosta, J., Adams, P. D., d’Adda di Fagagna, F., Baker, D. J., Bishop, C. L., Chandra, T., Collado, M., Gil, J., Gorgoulis, V., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.059 · Cited by 376 · see citing works
Self-citationMolecular mechanisms of gasdermin D pore-forming activity
Devant, P., & Kagan, J. C. (2023) · Nature Immunology · doi:10.1038/s41590-023-01526-w · Cited by 267 · see citing works
Gasdermins and pyroptosis in the kidney
Elias, E. E., Lyons, B., & Muruve, D. A. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00662-0 · Cited by 194 · see citing works
Montégut, L., López-Otı́n, C., & Kroemer, G. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02020-z · Cited by 203 · see citing works
Molecular mechanisms in MASLD/MASH-related HCC
Wang, X., Zhang, L., & Dong, B. (2024) · Hepatology · doi:10.1097/hep.0000000000000786 · Cited by 188 · see citing works
The Related Metabolic Diseases and Treatments of Obesity
Yang, M. J., Liu, S., & Zhang, C. (2022) · Healthcare · doi:10.3390/healthcare10091616 · Cited by 174 · see citing works
Friend or foe? The elusive role of hepatic stellate cells in liver cancer
Cogliati, B., Yashaswini, C. N., Wang, S., Sia, D., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00821-z · Cited by 157 · see citing works
The gasdermin family: emerging therapeutic targets in diseases
Zhu, C., Xu, S., Jiang, R., Yu, Y., Bian, J., & Zou, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01801-8 · Cited by 139 · see citing works
Hu, Y., Liu, Y., Zong, L., Zhang, W., Liu, R., Xing, Q., Liu, Z., Yan, Q., Li, W., Lei, H., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06382-y · Cited by 127 · see citing works
Cell senescence in liver diseases: pathological mechanism and theranostic opportunity
Sanfeliu-Redondo, D., Gibert-Ramos, A., & Gracia-Sancho, J. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00913-4 · Cited by 117 · see citing works
Zhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 93 · see citing works
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Jiang, X., Zhang, X., Cai, X., Li, N., Zheng, H., Tang, M., Zhu, J., Su, K., Zhang, R., Ye, N., et al. (2024) · Science Advances · doi:10.1126/sciadv.adi9284 · Cited by 79 · see citing works
Jang, D. S., Shin, J., Shim, E., Ohtani, N., & Jeon, O. H. (2024) · Aging Cell · doi:10.1111/acel.14315 · Cited by 84 · see citing works
Self-citationLiu, B., Peng, Z., Zhang, H., Zhang, N., Liu, Z., Xia, Z., Huang, S., Luo, P., & Cheng, Q. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02284-z · Cited by 82 · see citing works
Pan, C., Wu, Y., Hu, S., Li, K., Liu, X., Shi, Y., Lin, W., Wang, X., Shi, Y., Xu, Z., et al. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121217 · Cited by 71 · see citing works
The gasdermin protein family: emerging roles in gastrointestinal health and disease
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Liu, Y., He, H., Guo, X.-K., Wang, J., Wang, W., Li, D., Liang, S., Shao, F., Liu, W., & Hu, X. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.017 · Cited by 58 · see citing works
Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond
Ohtani, N., Kamiya, T., & Kawada, N. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000241 · Cited by 54 · see citing works
Self-citationWang, Y., Li, Y., Lin, Y., Cao, C.-Y., Chen, D., Huang, X., Li, C., Xu, H., Lai, H., Chen, H., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02413-z · Cited by 55 · see citing works
Gut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Rodrigues, S. G., der Merwe, V., Krag, A. A., & Wiest, R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2023.101859 · Cited by 51 · see citing works
Li, C., Cai, C., Wang, C., Chen, X., Zhang, B., & Huang, Z. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0857 · Cited by 56 · see citing works
Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease
Schwabe, R. F., Tacke, F., Sugimoto, A., & Friedman, S. L. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101421 · Cited by 50 · see citing works
Xu, L., Wei, C., Chen, Y., Wu, Y., Shou, X., Chen, W., Lu, D., Sun, H., Li, W., Yu, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34660-4 · Cited by 45 · see citing works
Self-citationCellular senescence in cancer: molecular mechanisms and therapeutic targets
Jin, P., Duan, X., Li, L., Zhou, P., Zou, C., & Xie, K. (2024) · MedComm · doi:10.1002/mco2.542 · Cited by 46 · see citing works
Systemic aging and aging‐related diseases
Li, Q., Xiao, N., Zhang, H., Liang, G., Lin, Y., Qian, Z., Yang, X. Y., Yang, J., Fu, Y., Zhang, C., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202402479rrr · Cited by 43 · see citing works
Gut microbial metabolites in cancer immunomodulation
Liu, H., Xiong, X., Zhu, W., Wang, S., Huang, W.-C., Zhu, G., Xu, H., & Yang, L. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02521-5 · Cited by 47 · see citing works
Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases
Wu, J., Wang, H., Gao, P., & Ouyang, S. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.06.026 · Cited by 42 · see citing works
Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting
Du, K., Umbaugh, D. S., Ren, N., & Diehl, A. M. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.08.021 · Cited by 42 · see citing works
Understanding gut dysbiosis for hepatocellular carcinoma diagnosis and treatment
Yu, J., Chen, X., Yang, X., & Zhang, B. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.06.003 · Cited by 40 · see citing works
The evidence-based multifaceted roles of hepatic stellate cells in liver diseases: A concise review
Kim, J., & Kim, Y. J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122547 · Cited by 39 · see citing works
Zhou, Z., Xu, J., Liu, S., Lv, Y., Zhang, R., Zhou, X., Zhang, Y., Weng, S., Xu, H. W., Ba, Y., et al. (2024) · Biomarker Research · doi:10.1186/s40364-024-00630-9 · Cited by 36 · see citing works
Chen, Y., Ma, L., Cheng, Z., Hu, Z., Xu, Y., Wu, J., Dai, Y., & Shi, C. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04972-8 · Cited by 39 · see citing works
Luo, X., Huang, W., Li, S., Sun, M., Hu, D. X., Jiang, J., Zhang, Z., Wang, Y., Wang, Y., Zhang, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202310304 · Cited by 33 · see citing works
Wang, H., Tsung, A., Mishra, L., & Huang, H. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105031 · Cited by 33 · see citing works
Senescent cells and SASP in cancer microenvironment: New approaches in cancer therapy
Özdemir, A., Demir, Y. D. Ş., Yeşilyurt, Z. E., & Ark, M. (2022) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2022.10.002 · Cited by 33 · see citing works
Western diet influences on microbiome and carcinogenesis
Newsome, R. C., Yang, Y., & Jobin, C. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101756 · Cited by 33 · see citing works
Dietary fat and lipid metabolism in the tumor microenvironment
Goswami, S., Zhang, Q., Celik, C. E., Reich, E. M., & Yilmaz, Ö. H. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188984 · Cited by 37 · see citing works
Immune aging and infectious diseases
Chen, R., Zou, J., Chen, J., Wang, L., Kang, R., & Tang, D. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003410 · Cited by 33 · see citing works
The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma
Yavuz, B. G., Datar, S. S., Chamseddine, S., Mohamed, Y. I., LaPelusa, M. B., Lee, S. S., Hu, Z. I., Koay, E. J., Cao, H. S. T., Jalal, P. K., et al. (2023) · Cancers · doi:10.3390/cancers15194875 · Cited by 28 · see citing works
Cellular Senescence in Hepatocellular Carcinoma: The Passenger or the Driver?
Cai, X., Guillot, A., & Liu, H. (2022) · Cells · doi:10.3390/cells12010132 · Cited by 30 · see citing works
Huang, D., Kidd, J. M., Zou, Y., Wu, X., Gehr, T. W. B., Li, P., & Li, G. (2023) · Inflammation · doi:10.1007/s10753-023-01861-y · Cited by 28 · see citing works
Inclan-Rico, J. M., Napuri, C. M., Lin, C., Hung, L., Ferguson, A. A., Liu, X., Wu, Q., Pastore, C., Stephenson, A., Femoe, U. M., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01982-y · Cited by 28 · see citing works
Wang, H., Yu, Y., Li, R., Zhang, H., Chen, Z., Sun, C., & Zhuang, J. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.022 · Cited by 32 · see citing works
Gasdermins: a dual role in pyroptosis and tumor immunity
Yang, J., & Jiang, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1322468 · Cited by 26 · see citing works
The role of pyroptosis in cancer: key components and therapeutic potential
Liu, Z., Xu, S., Chen, L., Gong, J., & Wang, M. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01932-z · Cited by 26 · see citing works
Liu, Z., Chen, Y., Yu, M., Yan, M., & Liang, H. (2023) · Molecules · doi:10.3390/molecules28237813 · Cited by 24 · see citing works
NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype
Muela‐Zarzuela, I., Suarez-Rivero, J. M., Gallardo-Orihuela, A., Wang, C., Izawa, K., de Gregorio-Procopio, M., Couillin, I., Ryffel, B., Kitaura, J., Sanz, A., et al. (2024) · Inflammation Research · doi:10.1007/s00011-024-01892-7 · Cited by 28 · see citing works
Taketomi, Y., Higashi, T., Kano, K., Miki, Y., Mochizuki, C., Toyoshima, S., Okayama, Y., Nishito, Y., Nakae, S., Tanaka, S., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.06.012 · Cited by 25 · see citing works
Self-citationNan, Y., Bai, Y., Hu, X., Zhou, K., Wu, T., Zhu, A., Li, M., Dou, Z., Cao, Z., Zhang, X., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009236 · Cited by 24 · see citing works
The interplay between cell death and senescence in cancer
Shimizu, K., Inuzuka, H., & Tokunaga, F. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.001 · Cited by 25 · see citing works
Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer
He, Y., Qiu, Y., Yang, X., Lu, G., & Zhao, S. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.002 · Cited by 25 · see citing works
Liu, Y., Wang, D., Liu, X., Yuan, H., Liu, D., Hu, Y., & Ning, S. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01966-3 · Cited by 23 · see citing works
Huang, M., Wang, D., Huang, J., Bae, A.-N., Xia, Y., Zhao, X., Mortaja, M., Azin, M., Collier, M. R., Semenov, Y. R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60894-z · Cited by 23 · see citing works
Plasticity, heterogeneity, and multifunctionality of hepatic stellate cells in liver pathophysiology
Du, K., Jun, J. H., Dutta, R. K., & Diehl, A. M. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000411 · Cited by 24 · see citing works
Stoess, C., Leszczynska, A., Kui, L., & Feldstein, A. E. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1218807 · Cited by 22 · see citing works
Kumar, A. R., Nair, B., Kamath, A. J., Nath, L. R., Călina, D. C., & Sharifi‐Rad, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-02072-3 · Cited by 21 · see citing works
Navigating the complex role of senescence in liver disease
Li, Q.-J., & Wang, L. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003439 · Cited by 23 · see citing works
Zeng, W., Liu, F., Liu, Y., Zhang, Z., Hu, H., Ning, S., Zhang, H., Chen, X., Liao, Z., & Zhang, Z. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0934 · Cited by 21 · see citing works
Role of gasdermin family proteins in cancers (Review)
Yang, X., & Tang, Z. (2023) · International Journal of Oncology · doi:10.3892/ijo.2023.5548 · Cited by 20 · see citing works
Toshida, K., Itoh, S., Iseda, N., Tomiyama, T., Yoshiya, S., Toshima, T., Liu, Y., Iwasaki, T., Okuzaki, D., Taniguchi, K., et al. (2024) · Liver International · doi:10.1111/liv.15839 · Cited by 19 · see citing works
Xiong, H., & Guo, J. (2025) · Pharmaceuticals · doi:10.3390/ph18040507 · Cited by 20 · see citing works
Role of cellular senescence in hepatic diseases (Review)
Xing, Y., & Zhu, J. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5623 · Cited by 18 · see citing works
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications
Mulla, J., Katti, R., & Scott, M. J. (2023) · Organogenesis · doi:10.1080/15476278.2023.2177484 · Cited by 18 · see citing works
Pyroptosis modulation by bacterial effector proteins
Chai, Q., Lei, Z., & Liu, C. H. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101804 · Cited by 18 · see citing works
Jiang, J., Chen, H., Zhao, C., Li, T., Zhang, C., Ma, L., Su, H., Ma, L., Duan, Z., Si, Q., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217584 · Cited by 17 · see citing works
Inflammasomes and pyroptosis in cancer: mechanisms and therapeutic advances
Seo, W., Jung, B., Roh, T., Shin, H. J., Song, I.-C., Chung, C., & Jo, E. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01763-6 · Cited by 18 · see citing works
Cernea, S., & Onișor, D. M. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i2.286 · Cited by 17 · see citing works
Zhang, C., Li, G., Zhang, F., Zhang, Y., Hong, S., Gao, S., Liu, Y., Du, J., & Li, Y. (2024) · Advanced Science · doi:10.1002/advs.202405299 · Cited by 16 · see citing works
Insights into the gut-liver axis: mechanisms and emerging therapies in hepatocellular carcinoma
Hu, Y., Gao, M., Chenghuang, J., & Bao, R. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1595853 · Cited by 16 · see citing works
Liver aging: underlying mechanisms and therapeutic strategies
Zhong, L., Wang, L., Syed, J. N., Yang, J., & Zhang, Y. (2025) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2025.101397 · Cited by 16 · see citing works
Chen, L., Gao, C., Yin, X., Mo, L., Cheng, X., Chen, H., Jiang, C., Wu, B., Zhao, Y., Li, H., et al. (2024) · MedComm · doi:10.1002/mco2.742 · Cited by 15 · see citing works
Mechanism-guided fine-tuned microbiome potentiates anti-tumor immunity in HCC
Liu, T., Guo, Y., Liao, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1333864 · Cited by 15 · see citing works
Li, D., Lan, X., Xu, L., Zhou, S., Luo, H., Zhang, X., Yu, W., Yang, Y., & Fang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1552010 · Cited by 17 · see citing works
Li, K., Lin, H., Yu, Y., Liu, Y., Yang, W., Chen, S., Li, X., Huang, W., Wang, H., Meng, C., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.02.060 · Cited by 14 · see citing works
Stromal senescence contributes to age-related increases in cancer
Ye, J., Melam, A., & Stewart, S. A. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00840-9 · Cited by 14 · see citing works
The Microbiome and Liver Cancer
Myojin, Y., & Greten, T. F. (2023) · The Cancer Journal · doi:10.1097/ppo.0000000000000646 · Cited by 14 · see citing works
Black phosphorus for bone regeneration: Mechanisms involved and influencing factors
Sun, T., Li, C., Luan, J., Zhao, F., Zhang, Y., Liu, J., & Shao, L. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101211 · Cited by 12 · see citing works
Ren, C., Yang, Z., Xu, E., Kang, X., Wang, X., Sun, Q., Wang, C., Zhang, L., Miao, J., Luo, B., et al. (2023) · Cancer Science · doi:10.1111/cas.16023 · Cited by 11 · see citing works
Jin, J., Cheng, K., Chen, M.-R., Liang, H., & Zhang, W.-G. (2025) · International Journal on Biological Sciences · doi:10.7150/ijbs.117394 · Cited by 14 · see citing works
Wang, Z., & Tang, N. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00788-1 · Cited by 11 · see citing works
Molecular Genealogy of Metabolic-associated Hepatocellular Carcinoma
Kodama, T., & Takehara, T. (2024) · Seminars in Liver Disease · doi:10.1055/a-2289-2298 · Cited by 11 · see citing works
Inflammation and Immunity in Liver Neoplasms: Implications for Future Therapeutic Strategies
Kim, J., & Seki, E. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0726 · Cited by 11 · see citing works
Szczerba, M., Ganesh, A., Gil-Marqués, M. L., Briken, V., & Goldberg, M. B. (2025) · mBio · doi:10.1128/mbio.00818-25 · Cited by 11 · see citing works
Burning down the house: Pyroptosis in the tumor microenvironment of hepatocellular carcinoma
Cheng, C., Hsu, S., Chen, Y., Liu, W., Shu, E.-D., Chien, C., Chiu, C., & Chang, W. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122627 · Cited by 11 · see citing works
Wang, Y., Gao, Y., Shi, H., Gao, R., Yang, J., Qu, Y., Hu, S., Zhang, J., Wang, J., Cao, J., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01764-9 · Cited by 10 · see citing works
Li, K., Yang, Y., Ma, M., Lu, S., & Li, J. (2023) · World Journal of Surgical Oncology · doi:10.1186/s12957-023-03090-x · Cited by 10 · see citing works
Babcock, I. W., Sibley, L. A., Labuzan, S. A., Cowan, M. N., Sethi, I., Alemu, S., Kelly, A. G., Kovacs, M. A., Lukens, J. R., & Harris, T. H. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012006 · Cited by 9 · see citing works
Hsu, S., Chen, Y.-E., Shu, E.-D., Ko, C., Chang, W., Lin, I., Li, C., Gallego, R. P., & Chiu, C. (2023) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-023-00678-9 · Cited by 9 · see citing works
Regulatory role of gut microbiota in immunotherapy of hepatocellular carcinoma
Du, J., Guan, Y., & Zhang, E. (2025) · Hepatology International · doi:10.1007/s12072-025-10822-6 · Cited by 8 · see citing works
Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments
Margheritis, E. G., Gehle, N., & Cosentino, K. (2025) · FEBS Journal · doi:10.1111/febs.70215 · Cited by 8 · see citing works
Cui, N., Jiang, L., Tang, L., & Tang, H. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112455 · Cited by 8 · see citing works
Zuo, S., Ma, J., Li, X., Fan, Z., Li, X., Luo, Y., & Su, L. (2025) · Microorganisms · doi:10.3390/microorganisms14010073 · Cited by 8 · see citing works
Pyroptosis: Turning Up the Heat on Cancer
Zhang, Z., & Lieberman, J. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-082423-041848 · Cited by 8 · see citing works
Regulatory T cells in cancer and inflammation
Yang, H., Zhang, H., Xia, N., & Cheng, X. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02584-w · Cited by 8 · see citing works
Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3
Korn, V., & Pluháčková, K. (2025) · Communications Chemistry · doi:10.1038/s42004-024-01400-2 · Cited by 7 · see citing works
Aging and Aging-Related Senescence in Liver
Ganguly, S., Sakane, S., Hokutan, K., Zhang, V., Miciano, C., Wang, A., Brenner, D. A., & Kisseleva, T. (2025) · Seminars in Liver Disease · doi:10.1055/a-2637-2549 · Cited by 8 · see citing works
- Authors
- Yamagishi, R., Kamachi, F., Nakamura, M., Yamazaki, S., Kamiya, T., Takasugi, M., Cheng, Y., Nonaka, Y., Yukawa-Muto, Y., Thuy, L. T. T., Harada, Y., Arai, T., Loo, T. M., Yoshimoto, S., Ando, T., Nakajima, M., Taguchi, H., Ishikawa, T., Akiba, H., Miyake, S., Kubo, M., Iwakura, Y., Fukuda, S., Chen, W.-Y., Kawada, N., Rudensky, A., Nakae, S., Hara, E., & Ohtani, N.
- Affiliations
- Osaka City University (JP)
- Tokyo University of Science (JP)
- Department of Pathophysiology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan (formerly, Osaka City University).
- Department of Hepatology, Osaka Metropolitan University, Graduate School of Medicine, Osaka, Japan (formerly, Osaka City University).
- Japanese Foundation For Cancer Research (JP)
- Institute for Advanced Biosciences, Keio University (JP)
- Juntendo University (JP)
- University of Tsukuba (JP)
- Kaohsiung Chang Gung Memorial Hospital (TW)
- Memorial Sloan Kettering Cancer Center (US)
- Hiroshima University (JP)
- Center for Infectious Disease Education and Research, The University of Osaka (JP)
- Corresponding author
- Yamagishi, Ryota
- Kamachi, Fumitaka
- Ohtani, Naoko
- ORCID
- Yamagishi, Ryota
- Kamachi, Fumitaka
- Yamazaki, Shota
- Kamiya, Tomonori
- Takasugi, Masaki
- Cheng, Yi
- Yukawa-Muto, Yoshimi
- Thuy, Le Thi Thanh
- Harada, Yohsuke
- Loo, Tze Mun
- Yoshimoto, Shin
- Ando, Tatsuya
- Nakajima, Masahiro
- Taguchi, Hayao
- Ishikawa, Takamasa
- Akiba, Hisaya
- Miyake, Sachiko
- Kubo, Masato
- Iwakura, Yoichiro
- Fukuda, Shinji
- Chen, Wei-Yu
- Kawada, Norifumi
- Rudensky, Alexander
- Nakae, Susumu
- Hara, Eiji
- Ohtani, Naoko
- Venue
- Science Immunology
- Published
- 2022-06-24
- Volume
- 7
- Issue
- 72
- Pages
- eabl7209-eabl7209
- ISSN
- 2470-9468 (ISSN-L)
- OpenAlex
- W4283362074
- Cited by
- 173
- References
- 63
- Citations by year
- 2026: 36 · 2025: 48 · 2024: 54 · 2023: 30 · 2022: 5
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- Locations
- Science Immunology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Osaka City University (Osaka City University) (submittedVersion)
- Funders
- Japan Agency for Medical Research and Development (JP20gm1010009, JP20gm5010001)
- Princess Takamatsu Cancer Research Fund (18‐25003)
- Yakult Bio-Science Foundation
- Japan Society for the Promotion of Science (21H02964, 20H03176, 25003, 23K24322, 22K08083, 19H04002, 19H03641, 20K15695, 18H02847, 20K16121, 20K16309, 21H02963, 22H00457)
- Japan Science and Technology Agency (JPMJPR18H6, JPMJFS 2138, JPMJER1902)
- Core Research for Evolutional Science and Technology (JP20gm1010009, JP20gm5010001)
- Precursory Research for Embryonic Science and Technology (JPMJPR18H6)
- Exploratory Research for Advanced Technology (JPMJER1902)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- gasdermin D, senescence-associated secretory phenotype, hepatic stellate cells, IL-1β, lipoteichoic acid, caspase-11, tumor microenvironment, high-fat diet, gut microbiota
- MeSH terms
- Interleukin-33, Gasdermins, Animals, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Obesity, Cellular Senescence, Phosphate-Binding Proteins, Mice, Pore Forming Cytotoxic Proteins, Hepatic Stellate Cells, Tumor Microenvironment
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