Kubicek, Stefan

Reversal of H3K9me2 by a Small-Molecule Inhibitor for the G9a Histone Methyltransferase

Kubicek, S., O'Sullivan, R. J., August, E. M., Hickey, E. R., Zhang, Q., Teodoro, M. L., Rea, S., Mechtler, K., Kowalski, J. A., Homon, C. A., et al. (2007) · Molecular Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 859

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 416

Rational discovery of molecular glue degraders via scalable chemical profiling

Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., et al. (2020) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 369

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., et al. (2016) · Nature Medicine

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

Cited by 256

Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders

Kornauth, C., Pemovska, T., Vladimer, G. I., Bayer, G., Bergmann, M., Eder, S., Eichner, R., Erl, M., Esterbauer, H., Exner, R., et al. (2022) · Cancer Discovery

Acute Myeloid Leukemia ResearchChronic Lymphocytic Leukemia Research

Cited by 206

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Winter, G. E., Radic, B., Mayor-Ruiz, C., Blomen, V. A., Trefzer, C., Kandasamy, R. K., Huber, K. V. M., Gridling, M., Chen, D., Klampfl, T., et al. (2014) · Nature Chemical Biology

Drug Transport and Resistance MechanismsCancer therapeutics and mechanisms

Cited by 175

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

Martins, R., Maier, J., Gorki, A.-D., Huber, K. V. M., Sharif, O., Starkl, P., Saluzzo, S., Quattrone, F., Gawish, R., Lakovits, K., et al. (2016) · Nature Immunology

Sepsis Diagnosis and TreatmentPhagocytosis and Immune Regulation

Cited by 142

Global survey of the immunomodulatory potential of common drugs

Vladimer, G. I., Snijder, B., Krall, N., Bigenzahn, J. W., Huber, K. V. M., Lardeau, C.-H., Sanjiv, K., Ringler, A., Berglund, U. W., Sabler, M., et al. (2017) · Nature Chemical Biology

Cancer Immunotherapy and BiomarkersImmunotoxicology and immune responses

Cited by 87

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

Schmidl, C., Vladimer, G. I., Rendeiro, A. F., Schnabl, S., Krausgruber, T., Taubert, C., Krall, N., Pemovska, T., Araghi, M., Snijder, B., et al. (2019) · Nature Chemical Biology

Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and Treatment

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