Keitel, Verena

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 1,280

Expression and function of the bile acid receptor TGR5 in Kupffer cells

Keitel, V., Donner, M., Winandy, S., Kubitz, R., & Häussinger, D. (2008) · Biochemical and Biophysical Research Communications

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 418

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

Keitel, V., Görg, B., Bidmon, H. J., Zemtsova, I., Spomer, L., Zilles, K., & Häussinger, D. (2010) · Glia

Neuroscience and Neuropharmacology ResearchDrug Transport and Resistance Mechanisms

Cited by 274

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

(DeCOI), G. C.-1. O. I., Aschenbrenner, A. C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., et al. (2021) · Genome Medicine

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 255

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

Haselow, K., Bode, J. G., Wammers, M., Ehlting, C., Keitel, V., Kleinebrecht, L., Schupp, A.-K., Häussinger, D., & Graf, D. (2013) · Journal of Leukocyte Biology

Immune Response and InflammationImmune cells in cancer

Cited by 164

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

Keitel, V., Ullmer, C., & Häussinger, D. (2010) · Biological Chemistry

Drug Transport and Resistance MechanismsGenetic and Kidney Cyst Diseases

Cited by 129

Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis

Reich, M., Spomer, L., Klindt, C., Fuchs, K., Stindt, J., Deutschmann, K., Höhne, J., Liaskou, E., Hov, J. R., Karlsen, T. H., et al. (2021) · Journal of Hepatology

Liver Diseases and ImmunityDrug Transport and Resistance Mechanisms

Cited by 121

Role of TGR5 (GPBAR1) in Liver Disease

Häussinger, D., & Keitel, V. (2018) · Seminars in Liver Disease

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 106

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ghallab, A., Hofmann, U., Sezgin, S., Vartak, N., Hassan, R., Zaza, A., Godoy, P., Schneider, K. M., Guenther, G., Ahmed, Y. A., et al. (2019) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 101

Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors

Keitel, V., Stindt, J., & Häussinger, D. (2019) · Handbook of Experimental Pharmacology

Drug Transport and Resistance MechanismsLiver physiology and pathology

Cited by 98

B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration

Behnke, K., Zhuang, Y., Xu, H. C., Sundaram, B., Reich, M., Shinde, P. V., Huang, J., Modares, N. F., Tumanov, A. V., Polz, R., et al. (2018) · Hepatology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 34